VTI1A (vesicle transport through interaction with t-SNAREs 1A)

2011-12-01  

Identity

HGNC
LOCATION
10q25.2
LOCUSID
ALIAS
MMDS3,MVti1,VTI1RP2,Vti1-rp2
FUSION GENES

Other Information

Locus ID:

NCBI: 143187
MIM: 614316
HGNC: 17792
Ensembl: ENSG00000151532

Variants:

dbSNP: 143187
ClinVar: 143187
TCGA: ENSG00000151532
COSMIC: VTI1A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000151532ENST00000393077Q96AJ9

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10

Pathways

PathwaySourceExternal ID
SNARE interactions in vesicular transportKEGGko04130
SNARE interactions in vesicular transportKEGGhsa04130
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Retrograde transport at the Trans-Golgi-NetworkREACTOMER-HSA-6811440
Intra-Golgi trafficREACTOMER-HSA-6811438

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
218921612011Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion.160
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
179751192008Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study.65
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
251052482014Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A.42
191381722009A VAMP7/Vti1a SNARE complex distinguishes a non-conventional traffic route to the cell surface used by KChIP1 and Kv4 potassium channels.20
190230992009Gene variants associated with ischemic stroke: the cardiovascular health study.16
236776962013VAMP4 is required to maintain the ribbon structure of the Golgi apparatus.11
246089662014High frequency of fusion transcripts involving TCF7L2 in colorectal cancer: novel fusion partner and splice variants.11
299757812018The VTI1A-TCF4 colon cancer fusion protein is a dominant negative regulator of Wnt signaling and is transcriptionally regulated by intestinal homeodomain factor CDX2.6

Citation

Dessen P

VTI1A (vesicle transport through interaction with t-SNAREs 1A)

Atlas Genet Cytogenet Oncol Haematol. 2011-12-01

Online version: http://atlasgeneticsoncology.org/gene/52508/vti1a