WAPL (WAPL cohesin release factor)

2015-08-01  

Identity

HGNC
LOCATION
10q23.2
LOCUSID
ALIAS
FOE,KIAA0261,WAPAL
FUSION GENES

Other Information

Locus ID:

NCBI: 23063
MIM: 610754
HGNC: 23293
Ensembl: ENSG00000062650

Variants:

dbSNP: 23063
ClinVar: 23063
TCGA: ENSG00000062650
COSMIC: WAPL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000062650ENST00000263070Q8WVX6
ENSG00000062650ENST00000298767Q7Z5K2
ENSG00000062650ENST00000372075F6QZY1
ENSG00000062650ENST00000618527Q7Z5K2

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
S PhaseREACTOMER-HSA-69242
Establishment of Sister Chromatid CohesionREACTOMER-HSA-2468052
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
Mitotic Telophase/CytokinesisREACTOMER-HSA-68884
Cohesin Loading onto ChromatinREACTOMER-HSA-2470946

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
171131382006Wapl controls the dynamic association of cohesin with chromatin.220
171127262006Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase.176
284758972017The Cohesin Release Factor WAPL Restricts Chromatin Loop Extension.121
292175912017Topologically associating domains and chromatin loops depend on cohesin and are regulated by CTCF, WAPL, and PDS5 proteins.92
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
227515012012Scc1 sumoylation by Mms21 promotes sister chromatid recombination through counteracting Wapl.40
237762032013Structure of the human cohesin inhibitor Wapl.31
240551532013WAPL-mediated removal of cohesin protects against segregation errors and aneuploidy.27
291382362018A kinase-dependent role for Haspin in antagonizing Wapl and protecting mitotic centromere cohesion.13

Citation

Dessen P

WAPL (WAPL cohesin release factor)

Atlas Genet Cytogenet Oncol Haematol. 2015-08-01

Online version: http://atlasgeneticsoncology.org/gene/55307/wapl