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WARS1 (tryptophanyl-tRNA synthetase 1)

Identity

Alias_namesIFI53
WARS
tryptophanyl-tRNA synthetase
Alias_symbol (synonym)IFP53
Other aliasGAMMA-2
HMN9
HGNC (Hugo) WARS1
LocusID (NCBI) 7453
Atlas_Id 51355
Location 14q32.2  [Link to chromosome band 14q32]
Location_base_pair Starts at 100333788 and ends at 100375590 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
WARS 14q32.2 C8orf12WARS 14q32.2 / CCNY 10p11.21WARS 14q32.2 / PPP2R3C 14q13.2
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  t(8;14)(p23;q32) WARS/FAM167A-AS1
t(10;14)(p11;q32) WARS/CCNY
t(14;14)(q13;q32) WARS/PPP2R3C
t(14;14)(q22;q32) WARS/KTN1


External links

Nomenclature
HGNC (Hugo)WARS1   12729
Cards
Entrez_Gene (NCBI)WARS1  7453  tryptophanyl-tRNA synthetase 1
AliasesGAMMA-2; HMN9; IFI53; IFP53; 
WARS
GeneCards (Weizmann)WARS1
Ensembl hg19 (Hinxton)ENSG00000140105 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000140105 [Gene_View]  ENSG00000140105 [Sequence]  chr14:100333788-100375590 [Contig_View]  WARS1 [Vega]
ICGC DataPortalENSG00000140105
TCGA cBioPortalWARS1
AceView (NCBI)WARS1
Genatlas (Paris)WARS1
WikiGenes7453
SOURCE (Princeton)WARS1
Genetics Home Reference (NIH)WARS1
Genomic and cartography
GoldenPath hg38 (UCSC)WARS1  -     chr14:100333788-100375590 -  -   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)WARS1  -     -   [Description]    (hg19-Feb_2009)
GoldenPathWARS1 - - [CytoView hg19]  WARS1 - - [CytoView hg38]
ImmunoBaseENSG00000140105
Mapping of homologs : NCBIWARS1 [Mapview hg19]  WARS1 [Mapview hg38]
OMIM191050   617721   
Gene and transcription
Genbank (Entrez)AK025487 AK056100 AK124668 AK130698 AK291141
RefSeq transcript (Entrez)NM_004184 NM_173701 NM_213645 NM_213646
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)WARS1
Cluster EST : UnigeneHs.497599 [ NCBI ]
CGAP (NCI)Hs.497599
Alternative Splicing GalleryENSG00000140105
Gene ExpressionWARS1 [ NCBI-GEO ]   WARS1 [ EBI - ARRAY_EXPRESS ]   WARS1 [ SEEK ]   WARS1 [ MEM ]
Gene Expression Viewer (FireBrowse)WARS1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7453
GTEX Portal (Tissue expression)WARS1
Human Protein AtlasENSG00000140105-WARS1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP23381   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP23381  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP23381
Splice isoforms : SwissVarP23381
Catalytic activity : Enzyme6.1.1.2 [ Enzyme-Expasy ]   6.1.1.26.1.1.2 [ IntEnz-EBI ]   6.1.1.2 [ BRENDA ]   6.1.1.2 [ KEGG ]   
PhosPhoSitePlusP23381
Domaine pattern : Prosite (Expaxy)AA_TRNA_LIGASE_I (PS00178)    WHEP_TRS_1 (PS00762)    WHEP_TRS_2 (PS51185)   
Domains : Interpro (EBI)aa-tRNA-synth_I_CS    aa-tRNA-synth_Ic    Rossmann-like_a/b/a_fold    S15_NS1_RNA-bd    Trp-tRNA-ligase    WHEP-TRS_dom   
Domain families : Pfam (Sanger)tRNA-synt_1b (PF00579)    WHEP-TRS (PF00458)   
Domain families : Pfam (NCBI)pfam00579    pfam00458   
Domain families : Smart (EMBL)WHEP-TRS (SM00991)  
Conserved Domain (NCBI)WARS1
DMDM Disease mutations7453
Blocks (Seattle)WARS1
PDB (RSDB)1O5T    1R6T    1R6U    1ULH    2AKE    2AZX    2DR2    2QUH    2QUI    2QUJ    2QUK    5UJI    5UJJ   
PDB Europe1O5T    1R6T    1R6U    1ULH    2AKE    2AZX    2DR2    2QUH    2QUI    2QUJ    2QUK    5UJI    5UJJ   
PDB (PDBSum)1O5T    1R6T    1R6U    1ULH    2AKE    2AZX    2DR2    2QUH    2QUI    2QUJ    2QUK    5UJI    5UJJ   
PDB (IMB)1O5T    1R6T    1R6U    1ULH    2AKE    2AZX    2DR2    2QUH    2QUI    2QUJ    2QUK    5UJI    5UJJ   
Structural Biology KnowledgeBase1O5T    1R6T    1R6U    1ULH    2AKE    2AZX    2DR2    2QUH    2QUI    2QUJ    2QUK    5UJI    5UJJ   
SCOP (Structural Classification of Proteins)1O5T    1R6T    1R6U    1ULH    2AKE    2AZX    2DR2    2QUH    2QUI    2QUJ    2QUK    5UJI    5UJJ   
CATH (Classification of proteins structures)1O5T    1R6T    1R6U    1ULH    2AKE    2AZX    2DR2    2QUH    2QUI    2QUJ    2QUK    5UJI    5UJJ   
SuperfamilyP23381
Human Protein Atlas [tissue]ENSG00000140105-WARS1 [tissue]
Peptide AtlasP23381
HPRD01845
IPIIPI00295400   IPI01024784   IPI01024903   IPI01025032   IPI01025153   IPI01026146   IPI01026267   IPI01026523   IPI01026173   IPI01025786   IPI01025155   IPI01026031   IPI01025287   IPI01025933   IPI01025659   IPI01025297   IPI01024905   IPI01025496   IPI00412737   IPI01026281   IPI01025033   IPI01026179   IPI01026283   IPI01026350   IPI01026528   IPI01025693   IPI01025791   IPI01025395   
Protein Interaction databases
DIP (DOE-UCLA)P23381
IntAct (EBI)P23381
FunCoupENSG00000140105
BioGRIDWARS1
STRING (EMBL)WARS1
ZODIACWARS1
Ontologies - Pathways
QuickGOP23381
Ontology : AmiGOangiogenesis  negative regulation of protein phosphorylation  tryptophan-tRNA ligase activity  tryptophan-tRNA ligase activity  tryptophan-tRNA ligase activity  protein binding  ATP binding  nucleus  nucleus  cytoplasm  cytoplasm  cytosol  cytosol  translation  tRNA aminoacylation for protein translation  tryptophanyl-tRNA aminoacylation  tryptophanyl-tRNA aminoacylation  negative regulation of protein kinase activity  negative regulation of cell proliferation  positive regulation of gene expression  regulation of protein ADP-ribosylation  kinase inhibitor activity  protein kinase binding  protein domain specific binding  positive regulation of protein complex assembly  protein-containing complex  protein homodimerization activity  regulation of angiogenesis  extracellular exosome  
Ontology : EGO-EBIangiogenesis  negative regulation of protein phosphorylation  tryptophan-tRNA ligase activity  tryptophan-tRNA ligase activity  tryptophan-tRNA ligase activity  protein binding  ATP binding  nucleus  nucleus  cytoplasm  cytoplasm  cytosol  cytosol  translation  tRNA aminoacylation for protein translation  tryptophanyl-tRNA aminoacylation  tryptophanyl-tRNA aminoacylation  negative regulation of protein kinase activity  negative regulation of cell proliferation  positive regulation of gene expression  regulation of protein ADP-ribosylation  kinase inhibitor activity  protein kinase binding  protein domain specific binding  positive regulation of protein complex assembly  protein-containing complex  protein homodimerization activity  regulation of angiogenesis  extracellular exosome  
NDEx NetworkWARS1
Atlas of Cancer Signalling NetworkWARS1
Wikipedia pathwaysWARS1
Orthology - Evolution
OrthoDB7453
GeneTree (enSembl)ENSG00000140105
Phylogenetic Trees/Animal Genes : TreeFamWARS1
HOGENOMP23381
Homologs : HomoloGeneWARS1
Homology/Alignments : Family Browser (UCSC)WARS1
Gene fusions - Rearrangements
Fusion : MitelmanWARS/CCNY [14q32.2/10p11.21]  
Fusion : MitelmanWARS/FAM167A-AS1 [14q32.2/8p23.1]  [t(8;14)(p23;q32)]  
Fusion : MitelmanWARS/KTN1 [14q32.2/14q22.3]  [t(14;14)(q22;q32)]  
Fusion : MitelmanWARS/PPP2R3C [14q32.2/14q13.2]  [t(14;14)(q13;q32)]  
Fusion PortalWARS 14q32.2 C8orf12 LUAD
Fusion PortalWARS 14q32.2 CCNY 10p11.21 THCA
Fusion PortalWARS 14q32.2 PPP2R3C 14q13.2 LUAD
Fusion : QuiverWARS1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWARS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WARS1
dbVarWARS1
ClinVarWARS1
1000_GenomesWARS1 
Exome Variant ServerWARS1
ExAC (Exome Aggregation Consortium)ENSG00000140105
GNOMAD BrowserENSG00000140105
Varsome BrowserWARS1
Genetic variants : HAPMAP7453
Genomic Variants (DGV)WARS1 [DGVbeta]
DECIPHERWARS1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisWARS1 
Mutations
ICGC Data PortalWARS1 
TCGA Data PortalWARS1 
Broad Tumor PortalWARS1
OASIS PortalWARS1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDWARS1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch WARS1
DgiDB (Drug Gene Interaction Database)WARS1
DoCM (Curated mutations)WARS1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WARS1 (select a term)
intoGenWARS1
Cancer3DWARS1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM191050    617721   
Orphanet
DisGeNETWARS1
MedgenWARS1
Genetic Testing Registry WARS1
NextProtP23381 [Medical]
TSGene7453
GENETestsWARS1
Target ValidationWARS1
Huge Navigator WARS1 [HugePedia]
snp3D : Map Gene to Disease7453
BioCentury BCIQWARS1
ClinGenWARS1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7453
Chemical/Pharm GKB GenePA37340
Clinical trialWARS1
Miscellaneous
canSAR (ICR)WARS1 (select the gene name)
DataMed IndexWARS1
Probes
Litterature
PubMed82 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWARS1
EVEXWARS1
GoPubMedWARS1
iHOPWARS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 18:15:08 CET 2019

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