WARS1 (tryptophanyl-tRNA synthetase 1)

2010-02-01  

Identity

HGNC
WARS1
LOCATION
14q32.2
LOCUSID
7453
ALIAS
GAMMA-2,HMN9,IFI53,IFP53,WARS
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7453
MIM: 191050
HGNC: 12729
Ensembl: ENSG00000140105

Variants:

dbSNP: 7453
ClinVar: 7453
TCGA: ENSG00000140105
COSMIC: WARS1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140105ENST00000344102P23381
ENSG00000140105ENST00000355338P23381
ENSG00000140105ENST00000355338A0A024R6K8
ENSG00000140105ENST00000358655P23381
ENSG00000140105ENST00000392882P23381
ENSG00000140105ENST00000392882A0A024R6K8
ENSG00000140105ENST00000553395G3V3Y5
ENSG00000140105ENST00000553413G3V5W1
ENSG00000140105ENST00000553524G3V3P2
ENSG00000140105ENST00000553545G3V4C7
ENSG00000140105ENST00000553581G3V5H5
ENSG00000140105ENST00000553769G3V4N8
ENSG00000140105ENST00000553934P78534
ENSG00000140105ENST00000554509G3V4N0
ENSG00000140105ENST00000554601H0YJP3
ENSG00000140105ENST00000554605G3V313
ENSG00000140105ENST00000554772G3V3X0
ENSG00000140105ENST00000554820G3V2C0
ENSG00000140105ENST00000555031G3V2F2
ENSG00000140105ENST00000555410G3V2Y7
ENSG00000140105ENST00000555813G3V4S4
ENSG00000140105ENST00000556209G3V339
ENSG00000140105ENST00000556295G3V3R3
ENSG00000140105ENST00000556338G3V423
ENSG00000140105ENST00000556435G3V5U1
ENSG00000140105ENST00000556504G3V3H8
ENSG00000140105ENST00000556645P23381
ENSG00000140105ENST00000556660G3V3S7
ENSG00000140105ENST00000556695G3V3R3
ENSG00000140105ENST00000556698G3V227
ENSG00000140105ENST00000556783G3V4A3
ENSG00000140105ENST00000557135P23381
ENSG00000140105ENST00000557135A0A024R6K8
ENSG00000140105ENST00000557297G3V456
ENSG00000140105ENST00000557347G3V4Q0
ENSG00000140105ENST00000557722G3V277
ENSG00000140105ENST00000627608G3V4Q0

Pathways

PathwaySourceExternal ID
Aminoacyl-tRNA biosynthesisKEGGko00970
Aminoacyl-tRNA biosynthesisKEGGhsa00970
Aminoacyl-tRNA biosynthesis, eukaryotesKEGGhsa_M00359
Aminoacyl-tRNA biosynthesis, eukaryotesKEGGM00359
Gene ExpressionREACTOMER-HSA-74160
tRNA AminoacylationREACTOMER-HSA-379724
Cytosolic tRNA aminoacylationREACTOMER-HSA-379716

References

Pubmed IDYearTitleCitations
117736262002A human aminoacyl-tRNA synthetase as a regulator of angiogenesis.111
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
117736252002A fragment of human TrpRS as a potent antagonist of ocular angiogenesis.59
146713302003Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains.43
167241122006Two conformations of a crystalline human tRNA synthetase-tRNA complex: implications for protein synthesis.29
167989142006Structure of human tryptophanyl-tRNA synthetase in complex with tRNATrp reveals the molecular basis of tRNA recognition and specificity.26
199009402009The prognostic significance of tryptophanyl-tRNA synthetase in colorectal cancer.20
146605602004Crystal structure of human tryptophanyl-tRNA synthetase catalytic fragment: insights into substrate recognition, tRNA binding, and angiogenesis activity.19
277487322016Secreted tryptophanyl-tRNA synthetase as a primary defence system against infection.19
283692202017A recurrent WARS mutation is a novel cause of autosomal dominant distal hereditary motor neuropathy.19

Citation

Dessen P

WARS1 (tryptophanyl-tRNA synthetase 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-02-01

Online version: http://atlasgeneticsoncology.org/gene/51355/wars1