WASHC1 (WASH complex subunit 1)

2017-04-01  

Identity

HGNC
WASHC1
LOCATION
9p24.3
LOCUSID
100287171
ALIAS
FAM39E,WASH,WASH1

Other Information

Locus ID:

NCBI: 100287171
MIM: 613632
HGNC: 24361
Ensembl: ENSG00000181404

Variants:

dbSNP: 100287171
ClinVar: 100287171
TCGA: ENSG00000181404
COSMIC: WASHC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000181404ENST00000442898A8K0Z3
ENSG00000181404ENST00000642633A0A2R8YDD3

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
appendix
spleen
lymph node
tonsil

References

Pubmed IDYearTitleCitations
225130872012Multiple repeat elements within the FAM21 tail link the WASH actin regulatory complex to the retromer.71
221143052011The Arp2/3 activator WASH regulates α5β1-integrin-mediated invasive migration.65
263653822015USP7 Acts as a Molecular Rheostat to Promote WASH-Dependent Endosomal Protein Recycling and Is Mutated in a Human Neurodevelopmental Disorder.47
260660812015WASH and Tsg101/ALIX-dependent diversion of stress-internalized EGFR from the canonical endocytic pathway.23
279092462017Retromer- and WASH-dependent sorting of nutrient transporters requires a multivalent interaction network with ANKRD50.18
254311352015Nuclear FAM21 participates in NF-κB-dependent gene regulation in pancreatic cancer cells.10
260412862015Intracellular Transport of Vaccinia Virus in HeLa Cells Requires WASH-VPEF/FAM21-Retromer Complexes and Recycling Molecules Rab11 and Rab22.10
298917222018HRS-WASH axis governs actin-mediated endosomal recycling and cell invasion.7
274416532016WASH has a critical role in NK cell cytotoxicity through Lck-mediated phosphorylation.4
285899392017WASH maintains NKp46+ ILC3 cells by promoting AHR expression.4

Citation

Dessen P

WASHC1 (WASH complex subunit 1)

Atlas Genet Cytogenet Oncol Haematol. 2017-04-01

Online version: http://atlasgeneticsoncology.org/gene/56793/washc1