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WBP2 (WW domain binding protein 2)

Identity

Alias_symbol (synonym)WBP-2
GRAMD6
Other aliasDFNB107
HGNC (Hugo) WBP2
LocusID (NCBI) 23558
Atlas_Id 57045
Location 17q25.1  [Link to chromosome band 17q25]
Location_base_pair Starts at 75845699 and ends at 75855335 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ABLIM1 (10q25.3) / WBP2 (17q25.1)ATHL1 (11p15.5) / WBP2 (17q25.1)LOC100132077 (9q22.32) / WBP2 (17q25.1)
RECQL5 (17q25.1) / WBP2 (17q25.1)UNC13A (19p13.11) / WBP2 (17q25.1)WBP2 (17q25.1) / FTL (19q13.33)
WBP2 (17q25.1) / NUP85 (17q25.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  RECQL5/WBP2 (17q25)

External links

Nomenclature
HGNC (Hugo)WBP2   12738
Cards
Entrez_Gene (NCBI)WBP2  23558  WW domain binding protein 2
AliasesDFNB107; GRAMD6; WBP-2
GeneCards (Weizmann)WBP2
Ensembl hg19 (Hinxton)ENSG00000132471 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000132471 [Gene_View]  ENSG00000132471 [Sequence]  chr17:75845699-75855335 [Contig_View]  WBP2 [Vega]
ICGC DataPortalENSG00000132471
TCGA cBioPortalWBP2
AceView (NCBI)WBP2
Genatlas (Paris)WBP2
WikiGenes23558
SOURCE (Princeton)WBP2
Genetics Home Reference (NIH)WBP2
Genomic and cartography
GoldenPath hg38 (UCSC)WBP2  -     chr17:75845699-75855335 -  17q25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)WBP2  -     17q25.1   [Description]    (hg19-Feb_2009)
GoldenPathWBP2 - 17q25.1 [CytoView hg19]  WBP2 - 17q25.1 [CytoView hg38]
ImmunoBaseENSG00000132471
Mapping of homologs : NCBIWBP2 [Mapview hg19]  WBP2 [Mapview hg38]
OMIM606962   617639   
Gene and transcription
Genbank (Entrez)AF087866 AK057881 AK094458 AK128407 AK293214
RefSeq transcript (Entrez)NM_001330499 NM_001348170 NM_012478
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)WBP2
Alternative Splicing GalleryENSG00000132471
Gene ExpressionWBP2 [ NCBI-GEO ]   WBP2 [ EBI - ARRAY_EXPRESS ]   WBP2 [ SEEK ]   WBP2 [ MEM ]
Gene Expression Viewer (FireBrowse)WBP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23558
GTEX Portal (Tissue expression)WBP2
Human Protein AtlasENSG00000132471-WBP2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ969T9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ969T9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ969T9
Splice isoforms : SwissVarQ969T9
PhosPhoSitePlusQ969T9
Domains : Interpro (EBI)GRAM    WBP2   
Domain families : Pfam (Sanger)GRAM (PF02893)   
Domain families : Pfam (NCBI)pfam02893   
Conserved Domain (NCBI)WBP2
DMDM Disease mutations23558
Blocks (Seattle)WBP2
SuperfamilyQ969T9
Human Protein Atlas [tissue]ENSG00000132471-WBP2 [tissue]
Peptide AtlasQ969T9
IPIIPI00032050   IPI00789465   IPI00797789   IPI00910281   IPI00909894   IPI00980197   
Protein Interaction databases
DIP (DOE-UCLA)Q969T9
IntAct (EBI)Q969T9
FunCoupENSG00000132471
BioGRIDWBP2
STRING (EMBL)WBP2
ZODIACWBP2
Ontologies - Pathways
QuickGOQ969T9
Ontology : AmiGOnuclear chromatin  RNA polymerase II proximal promoter sequence-specific DNA binding  transcription coactivator activity  transcription coactivator activity  transcription coactivator activity  protein binding  nucleus  nucleus  cytoplasm  estrogen receptor binding  chromatin DNA binding  chromatin DNA binding  response to progesterone  positive regulation of intracellular estrogen receptor signaling pathway  response to estrogen  establishment of protein localization  positive regulation of gene expression, epigenetic  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  progesterone receptor signaling pathway  cellular response to estrogen stimulus  positive regulation of histone H3-K14 acetylation  
Ontology : EGO-EBInuclear chromatin  RNA polymerase II proximal promoter sequence-specific DNA binding  transcription coactivator activity  transcription coactivator activity  transcription coactivator activity  protein binding  nucleus  nucleus  cytoplasm  estrogen receptor binding  chromatin DNA binding  chromatin DNA binding  response to progesterone  positive regulation of intracellular estrogen receptor signaling pathway  response to estrogen  establishment of protein localization  positive regulation of gene expression, epigenetic  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  progesterone receptor signaling pathway  cellular response to estrogen stimulus  positive regulation of histone H3-K14 acetylation  
NDEx NetworkWBP2
Atlas of Cancer Signalling NetworkWBP2
Wikipedia pathwaysWBP2
Orthology - Evolution
OrthoDB23558
GeneTree (enSembl)ENSG00000132471
Phylogenetic Trees/Animal Genes : TreeFamWBP2
HOGENOMQ969T9
Homologs : HomoloGeneWBP2
Homology/Alignments : Family Browser (UCSC)WBP2
Gene fusions - Rearrangements
Fusion : QuiverWBP2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWBP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WBP2
dbVarWBP2
ClinVarWBP2
1000_GenomesWBP2 
Exome Variant ServerWBP2
ExAC (Exome Aggregation Consortium)ENSG00000132471
GNOMAD BrowserENSG00000132471
Varsome BrowserWBP2
Genetic variants : HAPMAP23558
Genomic Variants (DGV)WBP2 [DGVbeta]
DECIPHERWBP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisWBP2 
Mutations
ICGC Data PortalWBP2 
TCGA Data PortalWBP2 
Broad Tumor PortalWBP2
OASIS PortalWBP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWBP2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DWBP2
Mutations and Diseases : HGMDWBP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch WBP2
DgiDB (Drug Gene Interaction Database)WBP2
DoCM (Curated mutations)WBP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WBP2 (select a term)
intoGenWBP2
Cancer3DWBP2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606962    617639   
Orphanet
DisGeNETWBP2
MedgenWBP2
Genetic Testing Registry WBP2
NextProtQ969T9 [Medical]
TSGene23558
GENETestsWBP2
Target ValidationWBP2
Huge Navigator WBP2 [HugePedia]
snp3D : Map Gene to Disease23558
BioCentury BCIQWBP2
ClinGenWBP2
Clinical trials, drugs, therapy
Protein Interactions : CTD23558
Pharm GKB GenePA37349
Clinical trialWBP2
Miscellaneous
canSAR (ICR)WBP2 (select the gene name)
HarmonizomeWBP2
DataMed IndexWBP2
Probes
Litterature
PubMed57 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWBP2
EVEXWBP2
GoPubMedWBP2
iHOPWBP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Jun 30 20:35:54 CEST 2020
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