WDFY2 (WD repeat and FYVE domain containing 2)

2015-02-01  

Identity

HGNC
LOCATION
13q14.3
LOCUSID
ALIAS
PROF,WDF2,ZFYVE22
FUSION GENES

Other Information

Locus ID:

NCBI: 115825
MIM: 610418
HGNC: 20482
Ensembl: ENSG00000139668

Variants:

dbSNP: 115825
ClinVar: 115825
TCGA: ENSG00000139668
COSMIC: WDFY2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139668ENST00000298125Q96P53
ENSG00000139668ENST00000612477A0A087WZX3

Expression (GTEx)

0
5
10
15
20
25

References

Pubmed IDYearTitleCitations
168735532006The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis.27
246756772014CDKN2D-WDFY2 is a cancer-specific fusion gene recurrent in high-grade serous ovarian carcinoma.17
167925292006A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda.16
173136512007WD-repeat-propeller-FYVE protein, ProF, binds VAMP2 and protein kinase Czeta.10
286539002017Overexpression of WDFY2 inhibits prostate cancer cell growth and migration via inactivation of Akt pathway.4
312538012019WDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling.3

Citation

Dessen P

WDFY2 (WD repeat and FYVE domain containing 2)

Atlas Genet Cytogenet Oncol Haematol. 2015-02-01

Online version: http://atlasgeneticsoncology.org/gene/55005/wdfy2