WDR20 (WD repeat domain 20)

2014-08-01  

Identity

HGNC
LOCATION
14q32.31
LOCUSID
ALIAS
Bun107,DMR
FUSION GENES

Other Information

Locus ID:

NCBI: 91833
MIM: 617741
HGNC: 19667
Ensembl: ENSG00000140153

Variants:

dbSNP: 91833
ClinVar: 91833
TCGA: ENSG00000140153
COSMIC: WDR20

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140153ENST00000299135Q8TBZ3
ENSG00000140153ENST00000322340Q8TBZ3
ENSG00000140153ENST00000335263Q8TBZ3
ENSG00000140153ENST00000342702Q8TBZ3
ENSG00000140153ENST00000424963A0A088AWN2
ENSG00000140153ENST00000454394Q8TBZ3
ENSG00000140153ENST00000555879Q8TBZ3
ENSG00000140153ENST00000556094G3V5V2
ENSG00000140153ENST00000556511Q8TBZ3
ENSG00000140153ENST00000556807Q8TBZ3
ENSG00000140153ENST00000558567H0YKE8
ENSG00000140153ENST00000558854H0YNU0
ENSG00000140153ENST00000559478H0YK31

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
201477372010WDR20 regulates activity of the USP12 x UAF1 deubiquitinating enzyme complex.41
273733362016Allosteric Activation of Ubiquitin-Specific Proteases by β-Propeller Proteins UAF1 and WDR20.13
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
267901282016Downregulation of WDR20 due to loss of 14q is involved in the malignant transformation of clear cell renal cell carcinoma.4
296558042018Characterization of WDR20: A new regulator of the ERAD machinery.1
304669592019WDR20 regulates shuttling of the USP12 deubiquitinase complex between the plasma membrane, cytoplasm and nucleus.0

Citation

Dessen P

WDR20 (WD repeat domain 20)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54776/wdr20