WDR4 (WD repeat domain 4)

2017-10-01 Affiliation

Identity

HGNC

WDR4

LOCATION

21q22.3

LOCUSID

10785

ALIAS

GAMOS6,MIGSB,TRM82,TRMT82,Wuho,hWH

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10785
MIM: 605924
HGNC: 12756
Ensembl: ENSG00000160193

Variants:

dbSNP: 10785
ClinVar: 10785
TCGA: ENSG00000160193
COSMIC: WDR4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000160193	ENST00000330317	P57081
ENSG00000160193	ENST00000398208	P57081

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Gene Expression	REACTOME	R-HSA-74160
tRNA processing	REACTOME	R-HSA-72306
tRNA modification in the nucleus and cytosol	REACTOME	R-HSA-6782315

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
26416026	2015	Mutation in WDR4 impairs tRNA m(7)G46 methylation and causes a distinct form of microcephalic primordial dwarfism.	24
28691927	2017	Ubiquitination of tumor suppressor PML regulates prometastatic and immunosuppressive tumor microenvironment.	9
26751069	2016	Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1.	5
28617965	2018	Further delineation of the phenotype caused by biallelic variants in the WDR4 gene.	5
30079490	2018	Mutations in WDR4 as a new cause of Galloway-Mowat syndrome.	2

Citation

Dessen P

WDR4 (WD repeat domain 4)

Atlas Genet Cytogenet Oncol Haematol. 2017-10-01

Online version: http://atlasgeneticsoncology.org/gene/57078/wdr4