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WDR45B (WD repeat domain 45B)

Identity

Alias (NCBI)NEDSBAS
WDR45L
WIPI-3
WIPI3
HGNC (Hugo) WDR45B
HGNC Alias symbWIPI3
HGNC Previous nameWDR45L
HGNC Previous nameWDR45-like
LocusID (NCBI) 56270
Atlas_Id 75716
Location 17q25.3  [Link to chromosome band 17q25]
Location_base_pair Starts at 82614562 and ends at 82648535 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
OGFOD3 (17q25.3) / WDR45B (17q25.3)WDR45B (17q25.3) / B3GNTL1 (17q25.3)WDR45B (17q25.3) / C17orf62 (17q25.3)
WDR45B (17q25.3) / RAB40B (17q25.3)WDR45B (17q25.3) / SEPT4 (17q22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(17;17)(q22;q25) WDR45B/SEPT4
WDR45B/B3GNTL1 (17q25)
WDR45B/RAB40B (17q25)


External links

Nomenclature
HGNC (Hugo)WDR45B   25072
Cards
Entrez_Gene (NCBI)WDR45B  56270  WD repeat domain 45B
AliasesNEDSBAS; WDR45L; WIPI-3; WIPI3
GeneCards (Weizmann)WDR45B
Ensembl hg19 (Hinxton)ENSG00000141580 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000141580 [Gene_View]  ENSG00000141580 [Sequence]  chr17:82614562-82648535 [Contig_View]  WDR45B [Vega]
ICGC DataPortalENSG00000141580
TCGA cBioPortalWDR45B
AceView (NCBI)WDR45B
Genatlas (Paris)WDR45B
WikiGenes56270
SOURCE (Princeton)WDR45B
Genetics Home Reference (NIH)WDR45B
Genomic and cartography
GoldenPath hg38 (UCSC)WDR45B  -     chr17:82614562-82648535 -  17q25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)WDR45B  -     17q25.3   [Description]    (hg19-Feb_2009)
GoldenPathWDR45B - 17q25.3 [CytoView hg19]  WDR45B - 17q25.3 [CytoView hg38]
ImmunoBaseENSG00000141580
genome Data Viewer NCBIWDR45B [Mapview hg19]  
OMIM609226   617977   
Gene and transcription
Genbank (Entrez)AA861045 AF091083 AK297477 AM182326 AY691427
RefSeq transcript (Entrez)NM_019613
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)WDR45B
Alternative Splicing GalleryENSG00000141580
Gene ExpressionWDR45B [ NCBI-GEO ]   WDR45B [ EBI - ARRAY_EXPRESS ]   WDR45B [ SEEK ]   WDR45B [ MEM ]
Gene Expression Viewer (FireBrowse)WDR45B [ Firebrowse - Broad ]
GenevisibleExpression of WDR45B in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)56270
GTEX Portal (Tissue expression)WDR45B
Human Protein AtlasENSG00000141580-WDR45B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5MNZ6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5MNZ6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5MNZ6
Splice isoforms : SwissVarQ5MNZ6
PhosPhoSitePlusQ5MNZ6
Domains : Interpro (EBI)WD40/YVTN_repeat-like_dom_sf    WD40_repeat    WD40_repeat_dom_sf   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)WD40 (SM00320)  
Conserved Domain (NCBI)WDR45B
DMDM Disease mutations56270
Blocks (Seattle)WDR45B
PDB (RSDB)6IYY   
PDB Europe6IYY   
PDB (PDBSum)6IYY   
PDB (IMB)6IYY   
Structural Biology KnowledgeBase6IYY   
SCOP (Structural Classification of Proteins)6IYY   
CATH (Classification of proteins structures)6IYY   
SuperfamilyQ5MNZ6
Human Protein Atlas [tissue]ENSG00000141580-WDR45B [tissue]
Peptide AtlasQ5MNZ6
HPRD15669
IPIIPI00021329   IPI01014836   
Protein Interaction databases
DIP (DOE-UCLA)Q5MNZ6
IntAct (EBI)Q5MNZ6
FunCoupENSG00000141580
BioGRIDWDR45B
STRING (EMBL)WDR45B
ZODIACWDR45B
Ontologies - Pathways
QuickGOQ5MNZ6
Ontology : AmiGOautophagosome assembly  autophagosome assembly  phagophore assembly site  autophagy of mitochondrion  protein binding  lysosome  cytosol  protein lipidation  cellular response to starvation  extrinsic component of membrane  phosphatidylinositol-3-phosphate binding  phosphatidylinositol-3-phosphate binding  phagophore assembly site membrane  protein localization to phagophore assembly site  phosphatidylinositol-3,5-bisphosphate binding  phosphatidylinositol-3,5-bisphosphate binding  
Ontology : EGO-EBIautophagosome assembly  autophagosome assembly  phagophore assembly site  autophagy of mitochondrion  protein binding  lysosome  cytosol  protein lipidation  cellular response to starvation  extrinsic component of membrane  phosphatidylinositol-3-phosphate binding  phosphatidylinositol-3-phosphate binding  phagophore assembly site membrane  protein localization to phagophore assembly site  phosphatidylinositol-3,5-bisphosphate binding  phosphatidylinositol-3,5-bisphosphate binding  
NDEx NetworkWDR45B
Atlas of Cancer Signalling NetworkWDR45B
Wikipedia pathwaysWDR45B
Orthology - Evolution
OrthoDB56270
GeneTree (enSembl)ENSG00000141580
Phylogenetic Trees/Animal Genes : TreeFamWDR45B
HOGENOMQ5MNZ6
Homologs : HomoloGeneWDR45B
Homology/Alignments : Family Browser (UCSC)WDR45B
Gene fusions - Rearrangements
Fusion : QuiverWDR45B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerWDR45B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)WDR45B
dbVarWDR45B
ClinVarWDR45B
1000_GenomesWDR45B 
Exome Variant ServerWDR45B
GNOMAD BrowserENSG00000141580
Varsome BrowserWDR45B
Genetic variants : HAPMAP56270
Genomic Variants (DGV)WDR45B [DGVbeta]
DECIPHERWDR45B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisWDR45B 
Mutations
ICGC Data PortalWDR45B 
TCGA Data PortalWDR45B 
Broad Tumor PortalWDR45B
OASIS PortalWDR45B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICWDR45B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DWDR45B
Mutations and Diseases : HGMDWDR45B
BioMutasearch WDR45B
DgiDB (Drug Gene Interaction Database)WDR45B
DoCM (Curated mutations)WDR45B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)WDR45B (select a term)
intoGenWDR45B
Cancer3DWDR45B(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609226    617977   
Orphanet
DisGeNETWDR45B
MedgenWDR45B
Genetic Testing Registry WDR45B
NextProtQ5MNZ6 [Medical]
TSGene56270
GENETestsWDR45B
Target ValidationWDR45B
Huge Navigator WDR45B [HugePedia]
snp3D : Map Gene to Disease56270
BioCentury BCIQWDR45B
ClinGenWDR45B
Clinical trials, drugs, therapy
Protein Interactions : CTD56270
Pharm GKB GenePA134894387
Clinical trialWDR45B
Miscellaneous
canSAR (ICR)WDR45B (select the gene name)
HarmonizomeWDR45B
DataMed IndexWDR45B
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineWDR45B
EVEXWDR45B
GoPubMedWDR45B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Jul 16 16:35:26 CEST 2020

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