WFIKKN1 (WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1)

2017-10-01  

Identity

HGNC
WFIKKN1
LOCATION
16p13.3
LOCUSID
117166
ALIAS
C16orf12,RJD2,WFDC20A,WFIKKN

Other Information

Locus ID:

NCBI: 117166
MIM: 608021
HGNC: 30912
Ensembl: ENSG00000127578

Variants:

dbSNP: 117166
ClinVar: 117166
TCGA: ENSG00000127578
COSMIC: WFIKKN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000127578ENST00000319070Q96NZ8

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
185960302008Both WFIKKN1 and WFIKKN2 have high affinity for growth and differentiation factors 8 and 11.25
210547892010WFIKKN1 and WFIKKN2 bind growth factors TGFβ1, BMP2 and BMP4 but do not inhibit their signalling activity.15
119288172002Distinct expression pattern of two related human proteins containing multiple types of protease-inhibitory modules.12
238296722013Latent myostatin has significant activity and this activity is controlled more efficiently by WFIKKN1 than by WFIKKN2.9
127090702003Expression, purification and characterization of the second Kunitz-type protease inhibitor domain of the human WFIKKN protein.4
167917412006Second Kunitz-type protease inhibitor domain of the human WFIKKN1 protein.3
273254602016WFIKKN1 and WFIKKN2: "Companion" proteins regulating TGFB activity.3
277823772016Influence of WFIKKN1 on BMP1-mediated activation of latent myostatin.1

Citation

Dessen P

WFIKKN1 (WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2017-10-01

Online version: http://atlasgeneticsoncology.org/gene/57054/wfikkn1