WIPI2 (WD repeat domain, phosphoinositide interacting 2)

2014-08-01  

Identity

HGNC
WIPI2
LOCATION
7p22.1
LOCUSID
26100
ALIAS
ATG18B,Atg21,CGI-50,IDDSSA,WIPI-2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 26100
MIM: 609225
HGNC: 32225
Ensembl: ENSG00000157954

Variants:

dbSNP: 26100
ClinVar: 26100
TCGA: ENSG00000157954
COSMIC: WIPI2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000157954ENST00000288828Q9Y4P8
ENSG00000157954ENST00000288828A0A024R823
ENSG00000157954ENST00000382384Q9Y4P8
ENSG00000157954ENST00000401525Q9Y4P8
ENSG00000157954ENST00000404704Q9Y4P8
ENSG00000157954ENST00000484262Q9Y4P8

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Autophagy - animalKEGGhsa04140
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852
Autophagy - otherKEGGko04136
Autophagy - otherKEGGhsa04136

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
205053592010Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation.229
205053592010Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation.229
249549042014WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1.184
273702082016Recruitment of TBK1 to cytosol-invading Salmonella induces WIPI2-dependent antibacterial autophagy.36
215645132011Freeze-fracture replica immunolabelling reveals human WIPI-1 and WIPI-2 as membrane proteins of autophagosomes.21
249917672014WIPI-dependent autophagy during neutrophil differentiation of NB4 acute promyelocytic leukemia cells.16
252334112014WIPI2b and Atg16L1: setting the stage for autophagosome formation.16
303400222018mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux.12
291335252018Optineurin promotes autophagosome formation by recruiting the autophagy-related Atg12-5-16L1 complex to phagophores containing the Wipi2 protein.11
254625582015Fluorescence-based imaging of autophagy progression by human WIPI protein detection.5

Citation

Dessen P

WIPI2 (WD repeat domain, phosphoinositide interacting 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54784/wipi2