WNT10A (Wnt family member 10A)

2003-02-01  

Identity

HGNC
LOCATION
2q35
LOCUSID
ALIAS
OODD,SSPS,STHAG4

Other Information

Locus ID:

NCBI: 80326
MIM: 606268
HGNC: 13829
Ensembl: ENSG00000135925

Variants:

dbSNP: 80326
ClinVar: 80326
TCGA: ENSG00000135925
COSMIC: WNT10A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135925ENST00000258411Q9GZT5
ENSG00000135925ENST00000258411A0A2K8FR47
ENSG00000135925ENST00000458582H7BZB8

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
mTOR signaling pathwayKEGGko04150
Wnt signaling pathwayKEGGko04310
MelanogenesisKEGGko04916
Basal cell carcinomaKEGGko05217
mTOR signaling pathwayKEGGhsa04150
Wnt signaling pathwayKEGGhsa04310
MelanogenesisKEGGhsa04916
Pathways in cancerKEGGhsa05200
Basal cell carcinomaKEGGhsa05217
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Signaling pathways regulating pluripotency of stem cellsKEGGhsa04550
Signaling pathways regulating pluripotency of stem cellsKEGGko04550
Wnt signalingKEGGhsa_M00677
Wnt signalingKEGGM00677
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
Signaling by WntREACTOMER-HSA-195721
WNT ligand biogenesis and traffickingREACTOMER-HSA-3238698
Breast cancerKEGGko05224
Breast cancerKEGGhsa05224

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
205856272010Web-based, participant-driven studies yield novel genetic associations for common traits.155
178470072007Mutation in WNT10A is associated with an autosomal recessive ectodermal dysplasia: the odonto-onycho-dermal dysplasia.67
225819712012Mutations in WNT10A are present in more than half of isolated hypodontia cases.60
209792332011Only four genes (EDA1, EDAR, EDARADD, and WNT10A) account for 90% of hypohidrotic/anhidrotic ectodermal dysplasia cases.52
195593982009WNT10A mutations are a frequent cause of a broad spectrum of ectodermal dysplasias with sex-biased manifestation pattern in heterozygotes.49
187872242008Constitutive activation of the Wnt canonical pathway in mantle cell lymphoma.39
212034632010Circadian disruption accelerates tumor growth and angio/stromagenesis through a Wnt signaling pathway.25
230940732012WNT10A plays an oncogenic role in renal cell carcinoma by activating WNT/β-catenin pathway.22
194713132009WNT10A missense mutation associated with a complete odonto-onycho-dermal dysplasia syndrome.21
194532612009High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.20

Citation

Dessen P

WNT10A (Wnt family member 10A)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42816/wnt10a