WNT7B (Wnt family member 7B)

2003-02-01  

Identity

HGNC
LOCATION
22q13.31
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 7477
MIM: 601967
HGNC: 12787
Ensembl: ENSG00000188064

Variants:

dbSNP: 7477
ClinVar: 7477
TCGA: ENSG00000188064
COSMIC: WNT7B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000188064ENST00000339464P56706
ENSG00000188064ENST00000409496A8K0G1
ENSG00000188064ENST00000410058B8A597
ENSG00000188064ENST00000410089B8A595
ENSG00000188064ENST00000428540B8A598

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
mTOR signaling pathwayKEGGko04150
Wnt signaling pathwayKEGGko04310
MelanogenesisKEGGko04916
Basal cell carcinomaKEGGko05217
mTOR signaling pathwayKEGGhsa04150
Wnt signaling pathwayKEGGhsa04310
MelanogenesisKEGGhsa04916
Pathways in cancerKEGGhsa05200
Basal cell carcinomaKEGGhsa05217
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Signaling pathways regulating pluripotency of stem cellsKEGGhsa04550
Signaling pathways regulating pluripotency of stem cellsKEGGko04550
Wnt signalingKEGGhsa_M00677
Wnt signalingKEGGM00677
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
Signaling by WntREACTOMER-HSA-195721
WNT ligand biogenesis and traffickingREACTOMER-HSA-3238698
Breast cancerKEGGko05224
Breast cancerKEGGhsa05224

References

Pubmed IDYearTitleCitations
246389822014Myeloid WNT7b mediates the angiogenic switch and metastasis in breast cancer.48
197343172009Mesenchymal stem cells produce Wnt isoforms and TGF-beta1 that mediate proliferation and procollagen expression by lung fibroblasts.42
234169782014WNT7B mediates autocrine Wnt/β-catenin signaling and anchorage-independent growth in pancreatic adenocarcinoma.37
296815112018A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment.24
229496352012Wnt ligands signal in a cooperative manner to promote foregut organogenesis.22
258235702015Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia.21
228384042012WNT7B in fibroblastic foci of idiopathic pulmonary fibrosis.19
206348912010Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia.18
233866862013Role of WNT7B-induced noncanonical pathway in advanced prostate cancer.16
265385472016Expression of WNT5A in Idiopathic Pulmonary Fibrosis and Its Control by TGF-β and WNT7B in Human Lung Fibroblasts.14

Citation

Dessen P

WNT7B (Wnt family member 7B)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42829/wnt7b