WNT8A (Wnt family member 8A)

2003-06-01  

Identity

HGNC
LOCATION
5q31.2
LOCUSID
ALIAS
WNT8D

Other Information

Locus ID:

NCBI: 7478
MIM: 606360
HGNC: 12788
Ensembl: ENSG00000061492

Variants:

dbSNP: 7478
ClinVar: 7478
TCGA: ENSG00000061492
COSMIC: WNT8A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000061492ENST00000361560Q9H1J5
ENSG00000061492ENST00000398754Q9H1J5
ENSG00000061492ENST00000504809D6RF94
ENSG00000061492ENST00000506684D6RF47

Expression (GTEx)

0
1
2

Pathways

PathwaySourceExternal ID
mTOR signaling pathwayKEGGko04150
Wnt signaling pathwayKEGGko04310
MelanogenesisKEGGko04916
Basal cell carcinomaKEGGko05217
mTOR signaling pathwayKEGGhsa04150
Wnt signaling pathwayKEGGhsa04310
MelanogenesisKEGGhsa04916
Pathways in cancerKEGGhsa05200
Basal cell carcinomaKEGGhsa05217
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Signaling pathways regulating pluripotency of stem cellsKEGGhsa04550
Signaling pathways regulating pluripotency of stem cellsKEGGko04550
Wnt signalingKEGGhsa_M00677
Wnt signalingKEGGM00677
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
Signaling by WntREACTOMER-HSA-195721
WNT ligand biogenesis and traffickingREACTOMER-HSA-3238698
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Disassembly of the destruction complex and recruitment of AXIN to the membraneREACTOMER-HSA-4641262
Breast cancerKEGGko05224
Breast cancerKEGGhsa05224

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
333574472021Structural Basis of WLS/Evi-Mediated Wnt Transport and Secretion.24
333574472021Structural Basis of WLS/Evi-Mediated Wnt Transport and Secretion.24
300608042018Wnt/PCP controls spreading of Wnt/β-catenin signals by cytonemes in vertebrates.63
300608042018Wnt/PCP controls spreading of Wnt/β-catenin signals by cytonemes in vertebrates.63
238364422013Polymorphisms and expression of the WNT8A gene in Hirschsprung's disease.2
238364422013Polymorphisms and expression of the WNT8A gene in Hirschsprung's disease.2
208909342010Studies with Wnt genes and nonsyndromic cleft lip and palate.39
208909342010Studies with Wnt genes and nonsyndromic cleft lip and palate.39
184133252008Variation in WNT genes is associated with non-syndromic cleft lip with or without cleft palate.82
184133252008Variation in WNT genes is associated with non-syndromic cleft lip with or without cleft palate.82
119565962002Expression and regulation of WNT8A and WNT8B mRNAs in human tumor cell lines: up-regulation of WNT8B mRNA by beta-estradiol in MCF-7 cells, and down-regulation of WNT8A and WNT8B mRNAs by retinoic acid in NT2 cells.6
119565962002Expression and regulation of WNT8A and WNT8B mRNAs in human tumor cell lines: up-regulation of WNT8B mRNA by beta-estradiol in MCF-7 cells, and down-regulation of WNT8A and WNT8B mRNAs by retinoic acid in NT2 cells.6

Citation

Dessen P

WNT8A (Wnt family member 8A)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/42830/wnt8a