WSB1 (WD repeat and SOCS box containing 1)

2008-09-01  

Identity

HGNC
LOCATION
17q11.1
LOCUSID
ALIAS
SWIP1,WSB-1
FUSION GENES

Other Information

Locus ID:

NCBI: 26118
MIM: 610091
HGNC: 19221
Ensembl: ENSG00000109046

Variants:

dbSNP: 26118
ClinVar: 26118
TCGA: ENSG00000109046
COSMIC: WSB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000109046ENST00000262394Q9Y6I7
ENSG00000109046ENST00000262394A0A024QZ51
ENSG00000109046ENST00000348811Q9Y6I7
ENSG00000109046ENST00000348811A0A024QZ36
ENSG00000109046ENST00000427287B4DGB8
ENSG00000109046ENST00000579733J3KRG6
ENSG00000109046ENST00000581185B4DTL1
ENSG00000109046ENST00000581440J3KT03
ENSG00000109046ENST00000582208J3QLM8
ENSG00000109046ENST00000583193J3KSQ3
ENSG00000109046ENST00000583742J3KS88
ENSG00000109046ENST00000584114J3KTB3

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
159654682005The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate.88
180939722008Ubiquitination and degradation of homeodomain-interacting protein kinase 2 by WD40 repeat/SOCS box protein WSB-1.37
204875062010A whole genome association study of mother-to-child transmission of HIV in Malawi.26
189786782008Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts.21
237921632013HIF1 regulates WSB-1 expression to promote hypoxia-induced chemoresistance in hepatocellular carcinoma cells.20
185755772008The WSB1 gene is involved in pancreatic cancer progression.15
265458112015WSB1 promotes tumor metastasis by inducing pVHL degradation.14
271535522016miR-592/WSB1/HIF-1α axis inhibits glycolytic metabolism to decrease hepatocellular carcinoma growth.13
168049162006Increased WSB1 copy number correlates with its over-expression which associates with increased survival in neuroblastoma.11
275427362016WSB1: from homeostasis to hypoxia.4

Citation

Dessen P

WSB1 (WD repeat and SOCS box containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2008-09-01

Online version: http://atlasgeneticsoncology.org/gene/50319/wsb1