WTIP (WT1 interacting protein)

2005-11-01  

Identity

HGNC
LOCATION
19q13.11
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 126374
MIM: 614790
HGNC: 20964
Ensembl: ENSG00000142279

Variants:

dbSNP: 126374
ClinVar: 126374
TCGA: ENSG00000142279
COSMIC: WTIP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000142279ENST00000585928K7EKM1
ENSG00000142279ENST00000590071A6NIX2

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Cellular responses to stressREACTOMER-HSA-2262752
Cellular response to hypoxiaREACTOMER-HSA-2262749
Regulation of Hypoxia-inducible Factor (HIF) by oxygenREACTOMER-HSA-1234174
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor AlphaREACTOMER-HSA-1234176
Hippo signaling pathway -multiple speciesKEGGko04392
Hippo signaling pathway -multiple speciesKEGGhsa04392

References

Pubmed IDYearTitleCitations
183317202008Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus.56
147368762004A WT1 co-regulator controls podocyte phenotype by shuttling between adhesion structures and nucleus.34
294402372018Tension-dependent regulation of mammalian Hippo signaling through LIMD1.17
200860152010Podocyte injury induces nuclear translocation of WTIP via microtubule-dependent transport.13
219004512012WT1-interacting protein (Wtip) regulates podocyte phenotype by cell-cell and cell-matrix contact reorganization.9
197859872009The LIM domain protein Wtip interacts with the receptor tyrosine kinase Ror2 and inhibits canonical Wnt signalling.7
216862242011Out on a LIM: chronic kidney disease, podocyte phenotype and the Wilm's tumor interacting protein (WTIP).6
270337052016Nephrin Suppresses Hippo Signaling through the Adaptor Proteins Nck and WTIP.4
250657432014WTIP interacts with ASXL2 and blocks ASXL2-mediated activation of retinoic acid signaling.2
275357602016WTIP interacts with BRCA2 and is essential for BRCA2 centrosome localization in cervical cancer cell.2

Citation

Dessen P

WTIP (WT1 interacting protein)

Atlas Genet Cytogenet Oncol Haematol. 2005-11-01

Online version: http://atlasgeneticsoncology.org/gene/43046/wtip