WWP2 (WW domain containing E3 ubiquitin protein ligase 2)

2007-04-01  

Identity

HGNC
LOCATION
16q22.1
LOCUSID
ALIAS
AIP2,WWp2-like
FUSION GENES

Other Information

Locus ID:

NCBI: 11060
MIM: 602308
HGNC: 16804
Ensembl: ENSG00000198373

Variants:

dbSNP: 11060
ClinVar: 11060
TCGA: ENSG00000198373
COSMIC: WWP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198373ENST00000356003O00308
ENSG00000198373ENST00000359154O00308
ENSG00000198373ENST00000359154A0A024R711
ENSG00000198373ENST00000561780H3BRX8
ENSG00000198373ENST00000563659H3BPJ8
ENSG00000198373ENST00000568684O00308
ENSG00000198373ENST00000569174O00308
ENSG00000198373ENST00000569620H3BS79

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120

References

Pubmed IDYearTitleCitations
185708722008cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination.383
215325862011WWP2 is an E3 ubiquitin ligase for PTEN.106
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
192740632009WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells.51
155485682005Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins.39
196519002009The HECT-type E3 ubiquitin ligase AIP2 inhibits activation-induced T-cell death by catalyzing EGR2 ubiquitination.26
284758702017A Tunable Brake for HECT Ubiquitin Ligases.26
121675932002Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channel.25
124503952002Adenovirus protein involved in virus internalization recruits ubiquitin-protein ligases.24
212584102011Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFβ signalling and EMT.23

Citation

Dessen P

WWP2 (WW domain containing E3 ubiquitin protein ligase 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/47485/wwp2