Identity
HGNC
LOCATION
22q12.1
LOCUSID
ALIAS
TREB-5,TREB5,XBP-1,XBP2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7494
MIM: 194355
HGNC: 12801
Ensembl: ENSG00000100219
Variants:
dbSNP: 7494
ClinVar: 7494
TCGA: ENSG00000100219
COSMIC: XBP1
RNA/Proteins
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164713176 | Platinum compounds | Chemical | ClinicalAnnotation | associated | PD | 23510626 | |
| PA443622 | Carcinoma, Non-Small-Cell Lung | Disease | ClinicalAnnotation | associated | PD | 23510626 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38146001 | 2024 | Innate IRE1α-XBP1 activation by viral single-stranded RNA and its influence on lung cytokine production during SARS-CoV-2 pneumonia. | 0 |
| 38322164 | 2024 | Expression and Clinical Significance of IRE1-XBP1s, p62, and Caspase-3 in Colorectal Cancer Patients. | 0 |
| 38648902 | 2024 | The IRE1α-XBP1 arm of the unfolded protein response is a host factor activated in SARS-CoV-2 infection. | 0 |
| 38688649 | 2024 | Correlation Between Low Cytoplasmic Expression of XBP1 and the Likelihood of Surviving Hepatocellular Carcinoma. | 0 |
| 38967361 | 2024 | X-Box binding protein 1 downregulates SIRT6 to promote injury in pancreatic ductal epithelial cells. | 0 |
| 38146001 | 2024 | Innate IRE1α-XBP1 activation by viral single-stranded RNA and its influence on lung cytokine production during SARS-CoV-2 pneumonia. | 0 |
| 38322164 | 2024 | Expression and Clinical Significance of IRE1-XBP1s, p62, and Caspase-3 in Colorectal Cancer Patients. | 0 |
| 38648902 | 2024 | The IRE1α-XBP1 arm of the unfolded protein response is a host factor activated in SARS-CoV-2 infection. | 0 |
| 38688649 | 2024 | Correlation Between Low Cytoplasmic Expression of XBP1 and the Likelihood of Surviving Hepatocellular Carcinoma. | 0 |
| 38967361 | 2024 | X-Box binding protein 1 downregulates SIRT6 to promote injury in pancreatic ductal epithelial cells. | 0 |
| 36639835 | 2023 | XBP1-elicited environment by chemotherapy potentiates repopulation of tongue cancer cells by enhancing miR-22/lncRNA/KAT6B-dependent NF-κB signalling. | 2 |
| 36768338 | 2023 | Enhanced IRE1α Phosphorylation/Oligomerization-Triggered XBP1 Splicing Contributes to Parkin-Mediated Prevention of SH-SY5Y Cell Death under Nitrosative Stress. | 1 |
| 36828260 | 2023 | XBP1s acts as a transcription factor of IRE1α and promotes proliferation of colon cancer cells. | 3 |
| 37054944 | 2023 | Single-cell RNA sequencing reveals XBP1-SLC38A2 axis as a metabolic regulator in cytotoxic T lymphocytes in multiple myeloma. | 3 |
| 37224754 | 2023 | Endoplasmic reticulum stress-triggered ferroptosis via the XBP1-Hrd1-Nrf2 pathway induces EMT progression in diabetic nephropathy. | 9 |
Citation
Dessen P
XBP1 (X-box binding protein 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-12-01
Online version: http://atlasgeneticsoncology.org/gene/42842/xbp1
