Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7518
MIM: 194363
HGNC: 12831
Ensembl: ENSG00000152422
Variants:
dbSNP: 7518
ClinVar: 7518
TCGA: ENSG00000152422
COSMIC: XRCC4
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA128406956 | fluorouracil | Chemical | ClinicalAnnotation | associated | PD | 28796378 | |
| PA164713176 | Platinum compounds | Chemical | ClinicalAnnotation | associated | PD | 28796378 | |
| PA166122986 | radiotherapy | Chemical | ClinicalAnnotation | associated | PD | 28796378 | |
| PA29116 | H2AFX | Gene | Pathway | associated | |||
| PA443622 | Carcinoma, Non-Small-Cell Lung | Disease | ClinicalAnnotation | associated | PK | PD | 20157331 |
| PA445742 | Stomach Neoplasms | Disease | ClinicalAnnotation | associated | PD | 28796378 | |
| PA449383 | docetaxel | Chemical | ClinicalAnnotation | associated | PK | PD | 20157331 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37099126 | 2024 | DNA Repair Enzyme XRCC4 30 bp Indel Intron 3 Locus Significant Association with Predisposition of Cataract in Senility. | 1 |
| 37099126 | 2024 | DNA Repair Enzyme XRCC4 30 bp Indel Intron 3 Locus Significant Association with Predisposition of Cataract in Senility. | 1 |
| 36524359 | 2023 | Genome stability‑related lncRNA ZFPM2‑AS1 promotes tumor progression via miR‑3065‑5p/XRCC4 in hepatocellular carcinoma. | 2 |
| 36765282 | 2023 | Systematic analysis identifies XRCC4 as a potential immunological and prognostic biomarker associated with pan-cancer. | 3 |
| 36940705 | 2023 | APTX acts in DNA double-strand break repair in a manner distinct from XRCC4. | 1 |
| 37955230 | 2023 | Androgen signaling stabilizes genomes to counteract senescence by promoting XRCC4 transcription. | 1 |
| 36524359 | 2023 | Genome stability‑related lncRNA ZFPM2‑AS1 promotes tumor progression via miR‑3065‑5p/XRCC4 in hepatocellular carcinoma. | 2 |
| 36765282 | 2023 | Systematic analysis identifies XRCC4 as a potential immunological and prognostic biomarker associated with pan-cancer. | 3 |
| 36940705 | 2023 | APTX acts in DNA double-strand break repair in a manner distinct from XRCC4. | 1 |
| 37955230 | 2023 | Androgen signaling stabilizes genomes to counteract senescence by promoting XRCC4 transcription. | 1 |
| 34990400 | 2022 | Dysregulation of X-ray repair cross-complementing 4 expression in the eutopic endometrium of women with endometriosis. | 2 |
| 35054780 | 2022 | XRCC4 and MRE11 Roles and Transcriptional Response to Repair of TALEN-Induced Double-Strand DNA Breaks. | 1 |
| 34990400 | 2022 | Dysregulation of X-ray repair cross-complementing 4 expression in the eutopic endometrium of women with endometriosis. | 2 |
| 35054780 | 2022 | XRCC4 and MRE11 Roles and Transcriptional Response to Repair of TALEN-Induced Double-Strand DNA Breaks. | 1 |
| 33725486 | 2021 | Caspase cleavage releases a nuclear protein fragment that stimulates phospholipid scrambling at the plasma membrane. | 8 |
Citation
Dessen P
XRCC4 (X-ray repair cross complementing 4)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/336/xrcc4
