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YARS1 (tyrosyl-tRNA synthetase 1)

Identity

Alias_namesYARS
tyrosyl-tRNA synthetase
Alias_symbol (synonym)YTS
YRS
tyrRS
Other aliasCMTDIC
TYRRS
HGNC (Hugo) YARS1
LocusID (NCBI) 8565
Atlas_Id 58124
Location 1p35.1  [Link to chromosome band 1p35]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


External links

Nomenclature
HGNC (Hugo)YARS1   12840
Cards
Entrez_Gene (NCBI)YARS1  8565  tyrosyl-tRNA synthetase 1
AliasesCMTDIC; TYRRS; YARS; YRS; 
YTS
GeneCards (Weizmann)YARS1
Ensembl hg19 (Hinxton)ENSG00000134684 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000134684 [Gene_View]  ENSG00000134684 [Sequence]  - [Contig_View]  YARS1 [Vega]
ICGC DataPortalENSG00000134684
TCGA cBioPortalYARS1
AceView (NCBI)YARS1
Genatlas (Paris)YARS1
WikiGenes8565
SOURCE (Princeton)YARS1
Genetics Home Reference (NIH)YARS1
Genomic and cartography
GoldenPath hg38 (UCSC)YARS1  -  
GoldenPath hg19 (UCSC)YARS1  -  
GoldenPathYARS1 - [CytoView hg19]  YARS1 - [CytoView hg38]
ImmunoBaseENSG00000134684
Mapping of homologs : NCBIYARS1 [Mapview hg19]  YARS1 [Mapview hg38]
OMIM603623   608323   
Gene and transcription
Genbank (Entrez)AK026535 AK125213 AK126444 AK127182 AK127879
RefSeq transcript (Entrez)NM_003680
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)YARS1
Cluster EST : UnigeneHs.213264 [ NCBI ]
CGAP (NCI)Hs.213264
Alternative Splicing GalleryENSG00000134684
Gene ExpressionYARS1 [ NCBI-GEO ]   YARS1 [ EBI - ARRAY_EXPRESS ]   YARS1 [ SEEK ]   YARS1 [ MEM ]
Gene Expression Viewer (FireBrowse)YARS1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8565
GTEX Portal (Tissue expression)YARS1
Human Protein AtlasENSG00000134684-YARS1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP54577   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP54577  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP54577
Splice isoforms : SwissVarP54577
Catalytic activity : Enzyme6.1.1.1 [ Enzyme-Expasy ]   6.1.1.16.1.1.1 [ IntEnz-EBI ]   6.1.1.1 [ BRENDA ]   6.1.1.1 [ KEGG ]   
PhosPhoSitePlusP54577
Domaine pattern : Prosite (Expaxy)TRBD (PS50886)   
Domains : Interpro (EBI)aa-tRNA-synth_Ic    NA-bd_OB-fold    Rossmann-like_a/b/a_fold    tRNA-bd_dom    Tyr-tRNA-ligase   
Domain families : Pfam (Sanger)tRNA-synt_1b (PF00579)    tRNA_bind (PF01588)   
Domain families : Pfam (NCBI)pfam00579    pfam01588   
Conserved Domain (NCBI)YARS1
DMDM Disease mutations8565
Blocks (Seattle)YARS1
PDB (RSDB)1N3L    1NTG    1Q11    4Q93    4QBT    5THH    5THL   
PDB Europe1N3L    1NTG    1Q11    4Q93    4QBT    5THH    5THL   
PDB (PDBSum)1N3L    1NTG    1Q11    4Q93    4QBT    5THH    5THL   
PDB (IMB)1N3L    1NTG    1Q11    4Q93    4QBT    5THH    5THL   
Structural Biology KnowledgeBase1N3L    1NTG    1Q11    4Q93    4QBT    5THH    5THL   
SCOP (Structural Classification of Proteins)1N3L    1NTG    1Q11    4Q93    4QBT    5THH    5THL   
CATH (Classification of proteins structures)1N3L    1NTG    1Q11    4Q93    4QBT    5THH    5THL   
SuperfamilyP54577
Human Protein Atlas [tissue]ENSG00000134684-YARS1 [tissue]
Peptide AtlasP54577
IPIIPI00007074   
Protein Interaction databases
DIP (DOE-UCLA)P54577
IntAct (EBI)P54577
FunCoupENSG00000134684
BioGRIDYARS1
STRING (EMBL)YARS1
ZODIACYARS1
Ontologies - Pathways
QuickGOP54577
Ontology : AmiGOtRNA binding  RNA binding  tyrosine-tRNA ligase activity  interleukin-8 receptor binding  protein binding  ATP binding  extracellular space  cytoplasm  cytosol  cytosol  tRNA aminoacylation for protein translation  tRNA aminoacylation for protein translation  tyrosyl-tRNA aminoacylation  apoptotic process  nuclear body  aminoacyl-tRNA synthetase multienzyme complex  
Ontology : EGO-EBItRNA binding  RNA binding  tyrosine-tRNA ligase activity  interleukin-8 receptor binding  protein binding  ATP binding  extracellular space  cytoplasm  cytosol  cytosol  tRNA aminoacylation for protein translation  tRNA aminoacylation for protein translation  tyrosyl-tRNA aminoacylation  apoptotic process  nuclear body  aminoacyl-tRNA synthetase multienzyme complex  
NDEx NetworkYARS1
Atlas of Cancer Signalling NetworkYARS1
Wikipedia pathwaysYARS1
Orthology - Evolution
OrthoDB8565
GeneTree (enSembl)ENSG00000134684
Phylogenetic Trees/Animal Genes : TreeFamYARS1
HOGENOMP54577
Homologs : HomoloGeneYARS1
Homology/Alignments : Family Browser (UCSC)YARS1
Gene fusions - Rearrangements
Fusion : QuiverYARS1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerYARS1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)YARS1
dbVarYARS1
ClinVarYARS1
1000_GenomesYARS1 
Exome Variant ServerYARS1
ExAC (Exome Aggregation Consortium)ENSG00000134684
GNOMAD BrowserENSG00000134684
Varsome BrowserYARS1
Genetic variants : HAPMAP8565
Genomic Variants (DGV)YARS1 [DGVbeta]
DECIPHERYARS1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisYARS1 
Mutations
ICGC Data PortalYARS1 
TCGA Data PortalYARS1 
Broad Tumor PortalYARS1
OASIS PortalYARS1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDYARS1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch YARS1
DgiDB (Drug Gene Interaction Database)YARS1
DoCM (Curated mutations)YARS1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)YARS1 (select a term)
intoGenYARS1
Cancer3DYARS1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603623    608323   
Orphanet
DisGeNETYARS1
MedgenYARS1
Genetic Testing Registry YARS1
NextProtP54577 [Medical]
TSGene8565
GENETestsYARS1
Target ValidationYARS1
Huge Navigator YARS1 [HugePedia]
snp3D : Map Gene to Disease8565
BioCentury BCIQYARS1
ClinGenYARS1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8565
Chemical/Pharm GKB GenePA37431
Clinical trialYARS1
Miscellaneous
canSAR (ICR)YARS1 (select the gene name)
DataMed IndexYARS1
Probes
Litterature
PubMed70 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineYARS1
EVEXYARS1
GoPubMedYARS1
iHOPYARS1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Nov 13 18:15:38 CET 2019

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