YOD1 (YOD1 deubiquitinase)

2015-08-01  

Identity

HGNC
LOCATION
1q32.1
LOCUSID
ALIAS
DUBA8,OTUD2,PRO0907

Other Information

Locus ID:

NCBI: 55432
MIM: 612023
HGNC: 25035
Ensembl: ENSG00000180667

Variants:

dbSNP: 55432
ClinVar: 55432
TCGA: ENSG00000180667
COSMIC: YOD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000180667ENST00000315927Q5VVQ6
ENSG00000180667ENST00000367084Q5VVQ6

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Ovarian tumor domain proteasesREACTOMER-HSA-5689896

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
198187072009The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER.88
277536222017VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy.49
257477182015MicroRNA-373 functions as an oncogene and targets YOD1 gene in cervical cancer.12
284166592017Deubiquitinase YOD1 potentiates YAP/TAZ activities through enhancing ITCH stability.12
282448692017YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-κB.7
264632072015The VCP/p97 and YOD1 Proteins Have Different Substrate-dependent Activities in Endoplasmic Reticulum-associated Degradation (ERAD).4
309528142019The Otubain YOD1 Suppresses Aggregation and Activation of the Signaling Adaptor MAVS through Lys63-Linked Deubiquitination.4
285022902017Deubiquitinase YOD1: the potent activator of YAP in hepatomegaly and liver cancer.2
301459842018Overexpression of YOD1 Promotes the Migration of Human Oral Keratinocytes by Enhancing TGF-β3 Signaling.1
303453042018Targeting YOD1 by RNA Interference Inhibits Proliferation and Migration of Human Oral Keratinocytes through Transforming Growth Factor-β3 Signaling Pathway.1

Citation

Dessen P

YOD1 (YOD1 deubiquitinase)

Atlas Genet Cytogenet Oncol Haematol. 2015-08-01

Online version: http://atlasgeneticsoncology.org/gene/55350/yod1