YTHDC1 (YTH domain containing 1)

2010-11-01  

Identity

HGNC
LOCATION
4q13.2
LOCUSID
ALIAS
YT521,YT521-B
FUSION GENES

Other Information

Locus ID:

NCBI: 91746
MIM: 617283
HGNC: 30626
Ensembl: ENSG00000083896

Variants:

dbSNP: 91746
ClinVar: 91746
TCGA: ENSG00000083896
COSMIC: YTHDC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000083896ENST00000344157Q96MU7
ENSG00000083896ENST00000355665Q96MU7
ENSG00000083896ENST00000505251J3KS01
ENSG00000083896ENST00000507529J3KRG5
ENSG00000083896ENST00000510746J3KRW0
ENSG00000083896ENST00000579690J3QR07

Expression (GTEx)

0
10
20
30
40
50
60
70

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
268769372016Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing.262
252425522014Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain.163
289842442017YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs.86
292623162017S-Adenosylmethionine Synthesis Is Regulated by Selective N6-Adenosine Methylation and mRNA Degradation Involving METTL16 and YTHDC1.38
127557012003Emerin interacts in vitro with the splicing-associated factor, YT521-B.28
270509312016Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing.21
151752722004The intranuclear localization and function of YT521-B is regulated by tyrosine phosphorylation.17
237654222014Hypoxia-dependent mRNA expression pattern of splicing factor YT521 and its impact on oncological important target gene expression.10
206863702010Alternative splicing-related factor YT521: an independent prognostic factor in endometrial cancer.9
238653452013The evaluation of the FOXO1, KLF9 and YT521 genes expression in human endometrial cancer.4

Citation

Dessen P

YTHDC1 (YTH domain containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-11-01

Online version: http://atlasgeneticsoncology.org/gene/51760/ythdc1