YWHAG (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma)

2007-02-01  

Identity

HGNC
LOCATION
7q11.23
LOCUSID
ALIAS
14-3-3GAMMA,DEE56,EIEE56,PPP1R170
FUSION GENES

Other Information

Locus ID:

NCBI: 7532
MIM: 605356
HGNC: 12852
Ensembl: ENSG00000170027

Variants:

dbSNP: 7532
ClinVar: 7532
TCGA: ENSG00000170027
COSMIC: YWHAG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170027ENST00000307630P61981

Expression (GTEx)

0
100
200
300
400
500
600

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
Cell cycleKEGGhsa04110
Oocyte meiosisKEGGko04114
Oocyte meiosisKEGGhsa04114
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Anchoring of the basal body to the plasma membraneREACTOMER-HSA-5620912
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases activate PKNsREACTOMER-HSA-5625740
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Metabolic GenesREACTOMER-HSA-5628897
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
G2/M DNA damage checkpointREACTOMER-HSA-69473
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexREACTOMER-HSA-75035
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270
Loss of proteins required for interphase microtubule organization from the centrosomeREACTOMER-HSA-380284
Loss of Nlp from mitotic centrosomesREACTOMER-HSA-380259
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Translocation of GLUT4 to the plasma membraneREACTOMER-HSA-1445148
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Intrinsic Pathway for ApoptosisREACTOMER-HSA-109606
Activation of BH3-only proteinsREACTOMER-HSA-114452
Activation of BAD and translocation to mitochondriaREACTOMER-HSA-111447
AURKA Activation by TPX2REACTOMER-HSA-8854518

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
385388042024YWHAG promotes colorectal cancer progression by regulating the CTTN-Wnt/β-catenin signaling axis.0
385388042024YWHAG promotes colorectal cancer progression by regulating the CTTN-Wnt/β-catenin signaling axis.0
377593882023YWHAG Deficiency Disrupts the EMT-Associated Network to Induce Oxidative Cell Death and Prevent Metastasis.2
377593882023YWHAG Deficiency Disrupts the EMT-Associated Network to Induce Oxidative Cell Death and Prevent Metastasis.2
349153492022Myoclonic epilepsy of infancy related to YWHAG gene mutation: towards a better phenotypic characterization.0
362437222022A heterozygous missense variant in the YWHAG gene causing developmental and epileptic encephalopathy 56 in a Chinese family.0
349153492022Myoclonic epilepsy of infancy related to YWHAG gene mutation: towards a better phenotypic characterization.0
362437222022A heterozygous missense variant in the YWHAG gene causing developmental and epileptic encephalopathy 56 in a Chinese family.0
330754942021Human adipocyte differentiation and composition of disease-relevant lipids are regulated by miR-221-3p.14
331598162021The 14-3-3/SLP76 protein-protein interaction in T-cell receptor signalling: a structural and biophysical characterization.4
333499182021Genetic diagnosis of infantile-onset epilepsy in the clinic: Application of whole-exome sequencing following epilepsy gene panel testing.11
333937342021Epilepsy and electroencephalogram evolution in YWHAG gene mutation: A new phenotype and review of the literature.3
33813791202114-3-3γ prevents centrosome duplication by inhibiting NPM1 function.1
34413451202114-3-3 proteins inactivate DAPK2 by promoting its dimerization and protecting key regulatory phosphosites.14
347099722021Long non-coding RNA NORAD protects against cerebral ischemia/reperfusion injury induced brain damage, cell apoptosis, oxidative stress and inflammation by regulating miR-30a-5p/YWHAG.15

Citation

Dessen P

YWHAG (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46119/ywhag