ZBTB7B (zinc finger and BTB domain containing 7B)

2013-08-01  

Identity

HGNC
ZBTB7B
LOCATION
1q21.3
LOCUSID
51043
ALIAS
CKROX,THPOK,ZBTB15,ZFP-67,ZFP67,ZNF857B,c-KROX,hcKROX
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51043
MIM: 607646
HGNC: 18668
Ensembl: ENSG00000160685

Variants:

dbSNP: 51043
ClinVar: 51043
TCGA: ENSG00000160685
COSMIC: ZBTB7B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160685ENST00000292176O15156
ENSG00000160685ENST00000368426O15156
ENSG00000160685ENST00000417934O15156
ENSG00000160685ENST00000535420O15156

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
194532612009High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.20
227305292012Epigenetic silencing of CD8 genes by ThPOK-mediated deacetylation during CD4 T cell differentiation.17
221398452012The p65 subunit of NF-κB inhibits COL1A1 gene transcription in human dermal and scleroderma fibroblasts through its recruitment on promoter by protein interaction with transcriptional activators (c-Krox, Sp1, and Sp3).16
176988442007Human collagen Krox up-regulates type I collagen expression in normal and scleroderma fibroblasts through interaction with Sp1 and Sp3 transcription factors.14
208109902010p300-mediated acetylation stabilizes the Th-inducing POK factor.11
194798902009Runx and ThPOK: a balancing act to regulate thymocyte lineage commitment.7
233150792013Cutting edge: fine-tuning of Thpok gene activation by an enhancer in close proximity to its own silencer.6
23609452201360-kDa Tat-interactive protein (TIP60) positively regulates Th-inducing POK (ThPOK)-mediated repression of eomesodermin in human CD4+ T cells.6
294888792018The transcription factors Runx3 and ThPOK cross-regulate acquisition of cytotoxic function by human Th1 lymphocytes.6
198867372009Regulation of Th-POK and Runx3 in T cell development in human thymoma.5

Citation

Dessen P

ZBTB7B (zinc finger and BTB domain containing 7B)

Atlas Genet Cytogenet Oncol Haematol. 2013-08-01

Online version: http://atlasgeneticsoncology.org/gene/53480/zbtb7b