Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ZCCHC7 (zinc finger CCHC-type containing 7)

Identity

Alias_symbol (synonym)FLJ22611
AIR1
Other aliasHSPC086
HGNC (Hugo) ZCCHC7
LocusID (NCBI) 84186
Atlas_Id 53062
Location 9p13.2  [Link to chromosome band 9p13]
Location_base_pair Starts at 37120472 and ends at 37358148 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CECR2 (22q11.1) / ZCCHC7 (9p13.2)DENND1B (1q31.3) / ZCCHC7 (9p13.2)MELK (9p13.2) / ZCCHC7 (9p13.2)
MYC (8q24.21) / ZCCHC7 (9p13.2)PAX5 (9p13.2) / ZCCHC7 (9p13.2)PVT1 (8q24.21) / ZCCHC7 (9p13.2)
SERINC3 (20q13.12) / ZCCHC7 (9p13.2)ZCCHC7 (9p13.2) / ASTN2 (9q33.1)ZCCHC7 (9p13.2) / DLEU2 (13q14.2)
ZCCHC7 (9p13.2) / GLIPR2 (9p13.3)ZCCHC7 (9p13.2) / LRRC19 (9p21.2)ZCCHC7 (9p13.2) / NR2C2 (3p25.1)
ZCCHC7 (9p13.2) / PAX5 (9p13.2)ZCCHC7 (9p13.2) / POLR1E (9p13.2)ZCCHC7 (9p13.2) / PRSS3 (9p13.3)
ZCCHC7 (9p13.2) / SERINC3 (20q13.12)ZCCHC7 (9p13.2) / UBAP1 (9p13.3)ZCCHC7 (9p13.2) / ZBTB7C (18q21.1)
ZCCHC7 9p13.2 / ASTN2 9q33.1ZCCHC7 9p13.2 / GLIPR2 9p13.3ZCCHC7 9p13.2 / LRRC19 9p21.2
ZCCHC7 9p13.2 / PRSS3 9p13.3ZCCHC7 9p13.2 / UBAP1 9p13.3ZCCHC7 9p13.2 / ZBTB7C 18q21.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 10 ]
  dic(9;20)(p13;q11) ZCCHC7/FRG1BP
dic(9;20)(p13;q11 ZCCHC7/LOC1499503
t(1;9)(q31;p13) DENND1B/ZCCHC7
t(8;9)(q24;p13) MYC/ZCCHC7
t(8;9)(q24;p13) PVT1/ZCCHC7
t(9;9)(p13;p13) PAX5/ZCCHC7
t(9;9)(p13;p13) ZCCHC7/PAX5
t(9;9)(p13;q33) DENND1A/ZCCHC7
t(9;20)(p13;q13) SERINC3/ZCCHC7
t(9;20)(p13;q13) ZCCHC7/SERINC3

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 6 ]
  ZCCHC7/GLIPR2 (9p13)
ZCCHC7/PRSS3 (9p13)
ZCCHC7/UBAP1 (9p13)
t(9;9)(p13;p21) ZCCHC7/LRRC19
t(9;9)(p13;q33) ZCCHC7/ASTN2
t(9;18)(p13;q21) ZCCHC7/ZBTB7C

External links

Nomenclature
HGNC (Hugo)ZCCHC7   26209
Cards
Entrez_Gene (NCBI)ZCCHC7  84186  zinc finger CCHC-type containing 7
AliasesAIR1; HSPC086
GeneCards (Weizmann)ZCCHC7
Ensembl hg19 (Hinxton)ENSG00000147905 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000147905 [Gene_View]  ENSG00000147905 [Sequence]  chr9:37120472-37358148 [Contig_View]  ZCCHC7 [Vega]
ICGC DataPortalENSG00000147905
TCGA cBioPortalZCCHC7
AceView (NCBI)ZCCHC7
Genatlas (Paris)ZCCHC7
WikiGenes84186
SOURCE (Princeton)ZCCHC7
Genetics Home Reference (NIH)ZCCHC7
Genomic and cartography
GoldenPath hg38 (UCSC)ZCCHC7  -     chr9:37120472-37358148 +  9p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ZCCHC7  -     9p13.2   [Description]    (hg19-Feb_2009)
GoldenPathZCCHC7 - 9p13.2 [CytoView hg19]  ZCCHC7 - 9p13.2 [CytoView hg38]
ImmunoBaseENSG00000147905
Mapping of homologs : NCBIZCCHC7 [Mapview hg19]  ZCCHC7 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AF161349 AI458621 AK026264 AK074608 AK303193
RefSeq transcript (Entrez)NM_001289119 NM_001289120 NM_001289121 NM_032226
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ZCCHC7
Cluster EST : UnigeneHs.654700 [ NCBI ]
CGAP (NCI)Hs.654700
Alternative Splicing GalleryENSG00000147905
Gene ExpressionZCCHC7 [ NCBI-GEO ]   ZCCHC7 [ EBI - ARRAY_EXPRESS ]   ZCCHC7 [ SEEK ]   ZCCHC7 [ MEM ]
Gene Expression Viewer (FireBrowse)ZCCHC7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84186
GTEX Portal (Tissue expression)ZCCHC7
Human Protein AtlasENSG00000147905-ZCCHC7 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N3Z6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N3Z6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N3Z6
Splice isoforms : SwissVarQ8N3Z6
PhosPhoSitePlusQ8N3Z6
Domaine pattern : Prosite (Expaxy)ZF_CCHC (PS50158)   
Domains : Interpro (EBI)Znf_CCHC    Znf_CCHC_sf   
Domain families : Pfam (Sanger)zf-CCHC (PF00098)   
Domain families : Pfam (NCBI)pfam00098   
Domain families : Smart (EMBL)ZnF_C2HC (SM00343)  
Conserved Domain (NCBI)ZCCHC7
DMDM Disease mutations84186
Blocks (Seattle)ZCCHC7
SuperfamilyQ8N3Z6
Human Protein Atlas [tissue]ENSG00000147905-ZCCHC7 [tissue]
Peptide AtlasQ8N3Z6
HPRD15703
IPIIPI00871360   IPI00166710   IPI01011102   
Protein Interaction databases
DIP (DOE-UCLA)Q8N3Z6
IntAct (EBI)Q8N3Z6
FunCoupENSG00000147905
BioGRIDZCCHC7
STRING (EMBL)ZCCHC7
ZODIACZCCHC7
Ontologies - Pathways
QuickGOQ8N3Z6
Ontology : AmiGORNA binding  protein binding  nucleolus  cytosol  zinc ion binding  
Ontology : EGO-EBIRNA binding  protein binding  nucleolus  cytosol  zinc ion binding  
Pathways : KEGGRNA degradation   
NDEx NetworkZCCHC7
Atlas of Cancer Signalling NetworkZCCHC7
Wikipedia pathwaysZCCHC7
Orthology - Evolution
OrthoDB84186
GeneTree (enSembl)ENSG00000147905
Phylogenetic Trees/Animal Genes : TreeFamZCCHC7
HOGENOMQ8N3Z6
Homologs : HomoloGeneZCCHC7
Homology/Alignments : Family Browser (UCSC)ZCCHC7
Gene fusions - Rearrangements
Fusion : MitelmanMYC/ZCCHC7 [8q24.21/9p13.2]  [t(8;9)(q24;p13)]  
Fusion : MitelmanPVT1/ZCCHC7 [8q24.21/9p13.2]  [t(8;9)(q24;p13)]  
Fusion : MitelmanZCCHC7/ASTN2 [9p13.2/9q33.1]  [t(9;9)(p13;q33)]  
Fusion : MitelmanZCCHC7/GLIPR2 [9p13.2/9p13.3]  [t(9;9)(p13;p13)]  
Fusion : MitelmanZCCHC7/LRRC19 [9p13.2/9p21.2]  [t(9;9)(p13;p21)]  
Fusion : MitelmanZCCHC7/PRSS3 [9p13.2/9p13.3]  [t(9;9)(p13;p13)]  
Fusion : MitelmanZCCHC7/UBAP1 [9p13.2/9p13.3]  [t(9;9)(p13;p13)]  
Fusion : MitelmanZCCHC7/ZBTB7C [9p13.2/18q21.1]  [t(9;18)(p13;q21)]  
Fusion PortalZCCHC7 9p13.2 ASTN2 9q33.1 BRCA
Fusion PortalZCCHC7 9p13.2 GLIPR2 9p13.3 BRCA
Fusion PortalZCCHC7 9p13.2 LRRC19 9p21.2 LUSC
Fusion PortalZCCHC7 9p13.2 PRSS3 9p13.3 OV
Fusion PortalZCCHC7 9p13.2 UBAP1 9p13.3 LUSC
Fusion PortalZCCHC7 9p13.2 ZBTB7C 18q21.1 LUSC
Fusion : QuiverZCCHC7
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerZCCHC7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZCCHC7
dbVarZCCHC7
ClinVarZCCHC7
1000_GenomesZCCHC7 
Exome Variant ServerZCCHC7
ExAC (Exome Aggregation Consortium)ENSG00000147905
GNOMAD BrowserENSG00000147905
Varsome BrowserZCCHC7
Genetic variants : HAPMAP84186
Genomic Variants (DGV)ZCCHC7 [DGVbeta]
DECIPHERZCCHC7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisZCCHC7 
Mutations
ICGC Data PortalZCCHC7 
TCGA Data PortalZCCHC7 
Broad Tumor PortalZCCHC7
OASIS PortalZCCHC7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICZCCHC7  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DZCCHC7
Mutations and Diseases : HGMDZCCHC7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ZCCHC7
DgiDB (Drug Gene Interaction Database)ZCCHC7
DoCM (Curated mutations)ZCCHC7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ZCCHC7 (select a term)
intoGenZCCHC7
Cancer3DZCCHC7(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETZCCHC7
MedgenZCCHC7
Genetic Testing Registry ZCCHC7
NextProtQ8N3Z6 [Medical]
TSGene84186
GENETestsZCCHC7
Target ValidationZCCHC7
Huge Navigator ZCCHC7 [HugePedia]
snp3D : Map Gene to Disease84186
BioCentury BCIQZCCHC7
ClinGenZCCHC7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84186
Chemical/Pharm GKB GenePA128394734
Clinical trialZCCHC7
Miscellaneous
canSAR (ICR)ZCCHC7 (select the gene name)
DataMed IndexZCCHC7
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineZCCHC7
EVEXZCCHC7
GoPubMedZCCHC7
iHOPZCCHC7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Nov 13 18:15:53 CET 2019
Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

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