ZDHHC5 (zinc finger DHHC-type palmitoyltransferase 5)

2015-03-01  

Identity

HGNC
ZDHHC5
LOCATION
11q12.1
LOCUSID
25921
ALIAS
DHHC5,ZNF375
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 25921
MIM: 614586
HGNC: 18472
Ensembl: ENSG00000156599

Variants:

dbSNP: 25921
ClinVar: 25921
TCGA: ENSG00000156599
COSMIC: ZDHHC5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156599ENST00000287169Q9C0B5
ENSG00000156599ENST00000287169A0A024R546
ENSG00000156599ENST00000527985Q9C0B5
ENSG00000156599ENST00000528177E9PMA5
ENSG00000156599ENST00000529447H0YEF4
ENSG00000156599ENST00000532842E9PJ97

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
198013772010Proteome scale characterization of human S-acylated proteins in lipid raft-enriched and non-raft membranes.127
287751652017EZH2 Palmitoylation Mediated by ZDHHC5 in p53-Mutant Glioma Drives Malignant Development and Progression.14
218204372011Somatostatin receptor 5 is palmitoylated by the interacting ZDHHC5 palmitoyltransferase.10
255739532015Systematic siRNA Screen Unmasks NSCLC Growth Dependence by Palmitoyltransferase DHHC5.9
306056772019DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane.9
316491952019Palmitoylation of NOD1 and NOD2 is required for bacterial sensing.4
287396892017LXR Activation Down-regulates Lipid Raft Markers FLOT2 and DHHC5 in MCF-7 Breast Cancer Cells.3
314026092019S-acylated Golga7b stabilises DHHC5 at the plasma membrane to regulate cell adhesion.1
318854232019MiR-96-5p inhibition induces cell apoptosis in gastric adenocarcinoma.0

Citation

Dessen P

ZDHHC5 (zinc finger DHHC-type palmitoyltransferase 5)

Atlas Genet Cytogenet Oncol Haematol. 2015-03-01

Online version: http://atlasgeneticsoncology.org/gene/55657/zdhhc5