ZDHHC7 (zinc finger DHHC-type palmitoyltransferase 7)

2014-07-01  

Identity

HGNC
ZDHHC7
LOCATION
16q24.1
LOCUSID
55625
ALIAS
DHHC7,SERZ-B,SERZ1,ZNF370
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55625
MIM: 614604
HGNC: 18459
Ensembl: ENSG00000153786

Variants:

dbSNP: 55625
ClinVar: 55625
TCGA: ENSG00000153786
COSMIC: ZDHHC7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000153786ENST00000313732Q9NXF8
ENSG00000153786ENST00000344861Q9NXF8
ENSG00000153786ENST00000564466Q9NXF8
ENSG00000153786ENST00000566909H3BNQ9
ENSG00000153786ENST00000569017H3BMI0

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447197Attention Deficit Disorder with HyperactivityDiseaseClinicalAnnotation, VariantAnnotationassociatedPD29382897
PA450464methylphenidateChemicalClinicalAnnotation, VariantAnnotationassociatedPD29382897

References

Pubmed IDYearTitleCitations
220312962012DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors.50
273803212016ZDHHC7-mediated S-palmitoylation of Scribble regulates cell polarity.20
253010682015Fas palmitoylation by the palmitoyl acyltransferase DHHC7 regulates Fas stability.14
281968652017S-Palmitoylation of Junctional Adhesion Molecule C Regulates Its Tight Junction Localization and Cell Migration.4
311835592019Deficiency of the palmitoyl acyltransferase ZDHHC7 impacts brain and behavior of mice in a sex-specific manner.1

Citation

Dessen P

ZDHHC7 (zinc finger DHHC-type palmitoyltransferase 7)

Atlas Genet Cytogenet Oncol Haematol. 2014-07-01

Online version: http://atlasgeneticsoncology.org/gene/54056/zdhhc7