ZFHX4 (zinc finger homeobox 4)

2007-02-01  

Identity

HGNC
ZFHX4
LOCATION
8q21.13
LOCUSID
79776
ALIAS
ZFH4,ZHF4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79776
MIM: 606940
HGNC: 30939
Ensembl: ENSG00000091656

Variants:

dbSNP: 79776
ClinVar: 79776
TCGA: ENSG00000091656
COSMIC: ZFHX4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000091656ENST00000517585E5RG79
ENSG00000091656ENST00000518282E7EVZ1
ENSG00000091656ENST00000519536H0YBV0
ENSG00000091656ENST00000520307E5RHS1
ENSG00000091656ENST00000523625H0YC81
ENSG00000091656ENST00000523809E5RGK3
ENSG00000091656ENST00000523885E5RI93
ENSG00000091656ENST00000651020A0A494BZV7
ENSG00000091656ENST00000651372Q86UP3

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
244407202014ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state.49
258551362015New basal cell carcinoma susceptibility loci.21
119353362002A candidate gene for congenital bilateral isolated ptosis identified by molecular analysis of a de novo balanced translocation.20
205466122010The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature.19
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
286944832017Somatic mutations in ZFHX4 gene are associated with poor overall survival of Chinese esophageal squamous cell carcinoma patients.3

Citation

Dessen P

ZFHX4 (zinc finger homeobox 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43935/zfhx4