ZFP36 (ZFP36 ring finger protein)

2007-02-01  

Identity

HGNC
LOCATION
19q13.2
LOCUSID
ALIAS
G0S24,GOS24,NUP475,RNF162A,TIS11,TTP,zfp-36
FUSION GENES

Other Information

Locus ID:

NCBI: 7538
MIM: 190700
HGNC: 12862
Ensembl: ENSG00000128016

Variants:

dbSNP: 7538
ClinVar: 7538
TCGA: ENSG00000128016
COSMIC: ZFP36

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128016ENST00000594045M0R252
ENSG00000128016ENST00000594442M0QY76
ENSG00000128016ENST00000597629P26651

Expression (GTEx)

0
500
1000
1500
2000

Pathways

PathwaySourceExternal ID
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Gene ExpressionREACTOMER-HSA-74160
Regulation of mRNA stability by proteins that bind AU-rich elementsREACTOMER-HSA-450531
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNAREACTOMER-HSA-450513

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
163649152005Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping.227
150144382004MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay.226
124409522002Tristetraprolin and other CCCH tandem zinc-finger proteins in the regulation of mRNA turnover.174
150673242004Gene expression profiling predicts clinical outcome of prostate cancer.171
173694042007TTP and BRF proteins nucleate processing body formation to silence mRNAs with AU-rich elements.114
127482832003Tristetraprolin and its family members can promote the cell-free deadenylation of AU-rich element-containing mRNAs by poly(A) ribonuclease.106
236445992013Structural basis for the recruitment of the human CCR4-NOT deadenylase complex by tristetraprolin.89
292464422017Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA.82
210788772011Phosphorylation of tristetraprolin by MK2 impairs AU-rich element mRNA decay by preventing deadenylase recruitment.80
151179382004RNA sequence elements required for high affinity binding by the zinc finger domain of tristetraprolin: conformational changes coupled to the bipartite nature of Au-rich MRNA-destabilizing motifs.78

Citation

Dessen P

ZFP36 (ZFP36 ring finger protein)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45691/zfp36