ZFYVE21 (zinc finger FYVE-type containing 21)

2013-11-01  

Identity

HGNC
ZFYVE21
LOCATION
14q32.33
LOCUSID
79038
ALIAS
HCVP7TP1,ZF21
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79038
MIM: 613504
HGNC: 20760
Ensembl: ENSG00000100711

Variants:

dbSNP: 79038
ClinVar: 79038
TCGA: ENSG00000100711
COSMIC: ZFYVE21

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100711ENST00000216602Q9BQ24
ENSG00000100711ENST00000311141Q9BQ24
ENSG00000100711ENST00000553512G3V2M2
ENSG00000100711ENST00000555163R4GN42
ENSG00000100711ENST00000556610G3V5D6

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
206010962010Single-nucleotide polymorphisms in DNA-repair genes and cutaneous melanoma.10
197732792009Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.6
217681102011ZF21 protein, a regulator of the disassembly of focal adhesions and cancer metastasis, contains a novel noncanonical pleckstrin homology domain.6
311139532019ZFYVE21 is a complement-induced Rab5 effector that activates non-canonical NF-κB via phosphoinosotide remodeling of endosomes.6
208901232011ZF21 is a new regulator of focal adhesion disassembly and a potential member of the spreading initiation center.4
233828032013The phosphoinositide-binding protein ZF21 regulates ECM degradation by invadopodia.3

Citation

Dessen P

ZFYVE21 (zinc finger FYVE-type containing 21)

Atlas Genet Cytogenet Oncol Haematol. 2013-11-01

Online version: http://atlasgeneticsoncology.org/gene/53575/zfyve21