ZFYVE26 (zinc finger FYVE-type containing 26)

2010-05-01  

Identity

HGNC
LOCATION
14q24.1
LOCUSID
ALIAS
FYVE-CENT,SPG15
FUSION GENES

Other Information

Locus ID:

NCBI: 23503
MIM: 612012
HGNC: 20761
Ensembl: ENSG00000072121

Variants:

dbSNP: 23503
ClinVar: 23503
TCGA: ENSG00000072121
COSMIC: ZFYVE26

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000072121ENST00000347230Q68DK2
ENSG00000072121ENST00000554557G3V230
ENSG00000072121ENST00000555452G3V2D8
ENSG00000072121ENST00000557306A0A2H2FF08

Expression (GTEx)

0
5
10
15
20

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
202085302010PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody.86
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
253652212014Spastic paraplegia proteins spastizin and spatacsin mediate autophagic lysosome reformation.55
183945782008Identification of the SPG15 gene, encoding spastizin, as a frequent cause of complicated autosomal-recessive spastic paraplegia, including Kjellin syndrome.52
238250252013Interaction between AP-5 and the hereditary spastic paraplegia proteins SPG11 and SPG15.38
240309502013Defective autophagy in spastizin mutated patients with hereditary spastic paraparesis type 15.26
215458382011Cellular distribution and subcellular localization of spatacsin and spastizin, two proteins involved in hereditary spastic paraplegia.24
199178232009Frequency and phenotype of SPG11 and SPG15 in complicated hereditary spastic paraplegia.20
198057272009SPG15 is the second most common cause of hereditary spastic paraplegia with thin corpus callosum.18
214555002011A tumor-associated mutation of FYVE-CENT prevents its interaction with Beclin 1 and interferes with cytokinesis.13

Citation

Dessen P

ZFYVE26 (zinc finger FYVE-type containing 26)

Atlas Genet Cytogenet Oncol Haematol. 2010-05-01

Online version: http://atlasgeneticsoncology.org/gene/51489/zfyve26