ZFYVE27 (zinc finger FYVE-type containing 27)

2014-11-01  

Identity

HGNC
ZFYVE27
LOCATION
10q24.2
LOCUSID
118813
ALIAS
PROTRUDIN,SPG33
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 118813
MIM: 610243
HGNC: 26559
Ensembl: ENSG00000155256

Variants:

dbSNP: 118813
ClinVar: 118813
TCGA: ENSG00000155256
COSMIC: ZFYVE27

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000155256ENST00000337540Q5T4F4
ENSG00000155256ENST00000357540Q5T4F4
ENSG00000155256ENST00000359980Q5T4F4
ENSG00000155256ENST00000370610Q5T4F4
ENSG00000155256ENST00000370613Q5T4F4
ENSG00000155256ENST00000393677Q5T4F4
ENSG00000155256ENST00000423811Q5T4F4

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
170824572006Protrudin induces neurite formation by directional membrane trafficking.67
168265252006ZFYVE27 (SPG33), a novel spastin-binding protein, is mutated in hereditary spastic paraplegia.37
219767012011Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation.36
192894702009Promotion of neurite extension by protrudin requires its interaction with vesicle-associated membrane protein-associated protein.29
239698312013Protrudin binds atlastins and endoplasmic reticulum-shaping proteins and regulates network formation.19
186063022008The role of ZFYVE27/protrudin in hereditary spastic paraplegia.10
225735512012Role of spastin and protrudin in neurite outgrowth.7

Citation

Dessen P

ZFYVE27 (zinc finger FYVE-type containing 27)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/75954/zfyve27