ZIC4 (Zic family member 4)

2012-12-01  

Identity

HGNC
ZIC4
LOCATION
3q24
LOCUSID
84107
ALIAS
-

Other Information

Locus ID:

NCBI: 84107
MIM: 608948
HGNC: 20393
Ensembl: ENSG00000174963

Variants:

dbSNP: 84107
ClinVar: 84107
TCGA: ENSG00000174963
COSMIC: ZIC4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000174963ENST00000383075Q8N9L1
ENSG00000174963ENST00000425731Q8N9L1
ENSG00000174963ENST00000462748C9JD04
ENSG00000174963ENST00000463250C9JZU7
ENSG00000174963ENST00000473123Q8N9L1
ENSG00000174963ENST00000484399Q8N9L1
ENSG00000174963ENST00000484586C9J6T3
ENSG00000174963ENST00000491672Q8N9L1
ENSG00000174963ENST00000525172Q8N9L1

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA449841haloperidolChemicalMultilinkAnnotationassociated27023437

References

Pubmed IDYearTitleCitations
153380082004Heterozygous deletion of the linked genes ZIC1 and ZIC4 is involved in Dandy-Walker malformation.54
222849682012Genome-wide analysis of CpG island methylation in bladder cancer identified TBX2, TBX3, GATA2, and ZIC4 as pTa-specific prognostic markers.37
275530892017Prognostic significance of the methylation of Wnt pathway antagonists-CXXC4, DACT2, and the inhibitors of sonic hedgehog signaling-ZIC1, ZIC4, and HHIP in head and neck squamous cell carcinomas.6
212042202011Dandy-Walker malformation associated with heterozygous ZIC1 and ZIC4 deletion: Report of a new patient.5

Citation

Dessen P

ZIC4 (Zic family member 4)

Atlas Genet Cytogenet Oncol Haematol. 2012-12-01

Online version: http://atlasgeneticsoncology.org/gene/53121/zic4