ZMYND8 (zinc finger MYND-type containing 8)

2003-08-01  

Identity

HGNC
LOCATION
20q13.12
LOCUSID
ALIAS
PRKCBP1,PRO2893,RACK7
FUSION GENES

Other Information

Locus ID:

NCBI: 23613
MIM: 615713
HGNC: 9397
Ensembl: ENSG00000101040

Variants:

dbSNP: 23613
ClinVar: 23613
TCGA: ENSG00000101040
COSMIC: ZMYND8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101040ENST00000262975Q9ULU4
ENSG00000101040ENST00000311275Q9ULU4
ENSG00000101040ENST00000352431Q9ULU4
ENSG00000101040ENST00000355972Q9ULU4
ENSG00000101040ENST00000360911Q9ULU4
ENSG00000101040ENST00000372023Q9ULU4
ENSG00000101040ENST00000396281Q9ULU4
ENSG00000101040ENST00000435836Q5TH12
ENSG00000101040ENST00000441977Q5TH07
ENSG00000101040ENST00000446894Q5TH08
ENSG00000101040ENST00000446994Q9ULU4
ENSG00000101040ENST00000458360Q9ULU4
ENSG00000101040ENST00000461685Q9ULU4
ENSG00000101040ENST00000467200H7C4X9
ENSG00000101040ENST00000471951Q9ULU4
ENSG00000101040ENST00000536340Q9ULU4
ENSG00000101040ENST00000540497Q9ULU4
ENSG00000101040ENST00000611941A0A087WYS3
ENSG00000101040ENST00000617418A0A087WVZ6
ENSG00000101040ENST00000619049A0A087WV57

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
255933092015Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.72
270586652016Suppression of Enhancer Overactivation by a RACK7-Histone Demethylase Complex.49
285721152017Histone demethylase KDM5A regulates the ZMYND8-NuRD chromatin remodeler to promote DNA repair.30
277328542016ZMYND8 Co-localizes with NuRD on Target Genes and Regulates Poly(ADP-Ribose)-Dependent Recruitment of GATAD2A/NuRD to Sites of DNA Damage.29
274779062016ZMYND8 Reads the Dual Histone Mark H3K4me1-H3K14ac to Antagonize the Expression of Metastasis-Linked Genes.28
279268742016Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin.23
266557212016Selective Recognition of H3.1K36 Dimethylation/H4K16 Acetylation Facilitates the Regulation of All-trans-retinoic Acid (ATRA)-responsive Genes by Putative Chromatin Reader ZMYND8.17
296299032018ZMYND8 acetylation mediates HIF-dependent breast cancer progression and metastasis.16
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11

Citation

Dessen P

ZMYND8 (zinc finger MYND-type containing 8)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41853/zmynd8