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ZNF274 (zinc finger protein 274)

Identity

Alias_symbol (synonym)ZKSCAN19
ZSCAN51
Other aliasHFB101
ZF2
HGNC (Hugo) ZNF274
LocusID (NCBI) 10782
Atlas_Id 76066
Location 19q13.43  [Link to chromosome band 19q13]
Location_base_pair Starts at 58182989 and ends at 58213562 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PI4KA (22q11.21) / ZNF274 (19q13.43)ZNF274 (19q13.43) / CACNA2D4 (12p13.33)ZNF274 (19q13.43) / ZNF274 (19q13.43)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias TL_t0919p24q13ID3358


External links

Nomenclature
HGNC (Hugo)ZNF274   13068
Cards
Entrez_Gene (NCBI)ZNF274  10782  zinc finger protein 274
AliasesHFB101; ZF2; ZKSCAN19; ZSCAN51
GeneCards (Weizmann)ZNF274
Ensembl hg19 (Hinxton)ENSG00000171606 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000171606 [Gene_View]  ENSG00000171606 [Sequence]  chr19:58182989-58213562 [Contig_View]  ZNF274 [Vega]
ICGC DataPortalENSG00000171606
TCGA cBioPortalZNF274
AceView (NCBI)ZNF274
Genatlas (Paris)ZNF274
WikiGenes10782
SOURCE (Princeton)ZNF274
Genetics Home Reference (NIH)ZNF274
Genomic and cartography
GoldenPath hg38 (UCSC)ZNF274  -     chr19:58182989-58213562 +  19q13.43   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ZNF274  -     19q13.43   [Description]    (hg19-Feb_2009)
GoldenPathZNF274 - 19q13.43 [CytoView hg19]  ZNF274 - 19q13.43 [CytoView hg38]
ImmunoBaseENSG00000171606
Mapping of homologs : NCBIZNF274 [Mapview hg19]  ZNF274 [Mapview hg38]
OMIM605467   
Gene and transcription
Genbank (Entrez)AB029149 AB029150 AF275680 AF275681 AK022328
RefSeq transcript (Entrez)NM_001278734 NM_001278735 NM_016324 NM_016325 NM_133502
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ZNF274
Cluster EST : UnigeneHs.83761 [ NCBI ]
CGAP (NCI)Hs.83761
Alternative Splicing GalleryENSG00000171606
Gene ExpressionZNF274 [ NCBI-GEO ]   ZNF274 [ EBI - ARRAY_EXPRESS ]   ZNF274 [ SEEK ]   ZNF274 [ MEM ]
Gene Expression Viewer (FireBrowse)ZNF274 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10782
GTEX Portal (Tissue expression)ZNF274
Human Protein AtlasENSG00000171606-ZNF274 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96GC6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96GC6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96GC6
Splice isoforms : SwissVarQ96GC6
PhosPhoSitePlusQ96GC6
Domaine pattern : Prosite (Expaxy)KRAB (PS50805)    SCAN_BOX (PS50804)    ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)KRAB    KRAB_dom_sf    SCAN_dom    SCAN_sf    Znf_C2H2_sf    Znf_C2H2_type   
Domain families : Pfam (Sanger)KRAB (PF01352)    SCAN (PF02023)   
Domain families : Pfam (NCBI)pfam01352    pfam02023   
Domain families : Smart (EMBL)KRAB (SM00349)  SCAN (SM00431)  ZnF_C2H2 (SM00355)  
Conserved Domain (NCBI)ZNF274
DMDM Disease mutations10782
Blocks (Seattle)ZNF274
SuperfamilyQ96GC6
Human Protein Atlas [tissue]ENSG00000171606-ZNF274 [tissue]
Peptide AtlasQ96GC6
HPRD05682
IPIIPI00062467   IPI00293932   IPI00218125   IPI00218126   IPI00910628   
Protein Interaction databases
DIP (DOE-UCLA)Q96GC6
IntAct (EBI)Q96GC6
FunCoupENSG00000171606
BioGRIDZNF274
STRING (EMBL)ZNF274
ZODIACZNF274
Ontologies - Pathways
QuickGOQ96GC6
Ontology : AmiGODNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  chromatin binding  DNA-binding transcription factor activity  transcription corepressor activity  protein binding  nucleolus  cytoplasm  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  sequence-specific DNA binding  metal ion binding  regulation of histone H3-K9 trimethylation  negative regulation of nucleic acid-templated transcription  
Ontology : EGO-EBIDNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  chromatin binding  DNA-binding transcription factor activity  transcription corepressor activity  protein binding  nucleolus  cytoplasm  regulation of transcription, DNA-templated  regulation of transcription by RNA polymerase II  sequence-specific DNA binding  metal ion binding  regulation of histone H3-K9 trimethylation  negative regulation of nucleic acid-templated transcription  
NDEx NetworkZNF274
Atlas of Cancer Signalling NetworkZNF274
Wikipedia pathwaysZNF274
Orthology - Evolution
OrthoDB10782
GeneTree (enSembl)ENSG00000171606
Phylogenetic Trees/Animal Genes : TreeFamZNF274
HOGENOMQ96GC6
Homologs : HomoloGeneZNF274
Homology/Alignments : Family Browser (UCSC)ZNF274
Gene fusions - Rearrangements
Fusion : QuiverZNF274
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerZNF274 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZNF274
dbVarZNF274
ClinVarZNF274
1000_GenomesZNF274 
Exome Variant ServerZNF274
ExAC (Exome Aggregation Consortium)ENSG00000171606
GNOMAD BrowserENSG00000171606
Varsome BrowserZNF274
Genetic variants : HAPMAP10782
Genomic Variants (DGV)ZNF274 [DGVbeta]
DECIPHERZNF274 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisZNF274 
Mutations
ICGC Data PortalZNF274 
TCGA Data PortalZNF274 
Broad Tumor PortalZNF274
OASIS PortalZNF274 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICZNF274  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DZNF274
Mutations and Diseases : HGMDZNF274
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ZNF274
DgiDB (Drug Gene Interaction Database)ZNF274
DoCM (Curated mutations)ZNF274 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ZNF274 (select a term)
intoGenZNF274
Cancer3DZNF274(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605467   
Orphanet
DisGeNETZNF274
MedgenZNF274
Genetic Testing Registry ZNF274
NextProtQ96GC6 [Medical]
TSGene10782
GENETestsZNF274
Target ValidationZNF274
Huge Navigator ZNF274 [HugePedia]
snp3D : Map Gene to Disease10782
BioCentury BCIQZNF274
ClinGenZNF274
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10782
Chemical/Pharm GKB GenePA37644
Clinical trialZNF274
Miscellaneous
canSAR (ICR)ZNF274 (select the gene name)
DataMed IndexZNF274
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineZNF274
EVEXZNF274
GoPubMedZNF274
iHOPZNF274
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Sep 3 16:13:53 CEST 2019

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