ZNF300 (zinc finger protein 300)

2011-02-01  

Identity

HGNC
ZNF300
LOCATION
5q33.1
LOCUSID
91975
ALIAS
-

Other Information

Locus ID:

NCBI: 91975
MIM: 612429
HGNC: 13091
Ensembl: ENSG00000145908

Variants:

dbSNP: 91975
ClinVar: 91975
TCGA: ENSG00000145908
COSMIC: ZNF300

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145908ENST00000274599Q96RE9
ENSG00000145908ENST00000394226A0A0A0MS50
ENSG00000145908ENST00000418587Q96RE9
ENSG00000145908ENST00000427179F8WE31
ENSG00000145908ENST00000446148Q96RE9

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
205495152010Genome-wide searching of rare genetic variants in WTCCC data.29
217773762012Overexpression of the human ZNF300 gene enhances growth and metastasis of cancer cells through activating NF-kB pathway.12
243931312014ZNF300P1 encodes a lincRNA that regulates cell polarity and is epigenetically silenced in type II epithelial ovarian cancer.12
204710862010PU.1 can regulate the ZNF300 promoter in APL-derived promyelocytes HL-60.7
183502572008Identification of the DNA binding element of the human ZNF300 protein.4
205858882010ZNF300, a recently identified human transcription factor, activates the human IL-2Rβ promoter through the overlapping ZNF300/EGR1 binding site.3
175418382007Molecular cloning and characterization of a novel splice variant of human ZNF300 gene, which expressed highly in testis.2
305680002019ZNF300 stimulates fatty acid oxidation and alleviates hepatosteatosis through regulating PPARα.0

Citation

Dessen P

ZNF300 (zinc finger protein 300)

Atlas Genet Cytogenet Oncol Haematol. 2011-02-01

Online version: http://atlasgeneticsoncology.org/gene/52059/znf300