ZNF350 (zinc finger protein 350)

2003-02-01  

Identity

HGNC
ZNF350
LOCATION
19q13.41
LOCUSID
59348
ALIAS
ZBRK1,ZFQR
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 59348
MIM: 605422
HGNC: 16656
Ensembl: ENSG00000256683

Variants:

dbSNP: 59348
ClinVar: 59348
TCGA: ENSG00000256683
COSMIC: ZNF350

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000256683ENST00000243644Q9GZX5
ENSG00000256683ENST00000593596M0R1T8
ENSG00000256683ENST00000594929M0QY52
ENSG00000256683ENST00000597788M0QYT6
ENSG00000256683ENST00000601430M0R017

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
202212602010KRAB-zinc finger proteins and KAP1 can mediate long-range transcriptional repression through heterochromatin spreading.134
164851362006Polymorphisms in DNA double-strand break repair genes and risk of breast cancer: two population-based studies in USA and Poland, and meta-analyses.53
201503662010DNA repair gene polymorphisms and risk of adult meningioma, glioma, and acoustic neuroma.46
175579042007Evaluation of genetic variation in the double-strand break repair pathway and bladder cancer risk.32
186766802008Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.32
155968202005The Epstein-Barr virus replication protein BBLF2/3 provides an origin-tethering function through interaction with the zinc finger DNA binding protein ZBRK1 and the KAP-1 corepressor.28
151134412004Kin-cohort estimates for familial breast cancer risk in relation to variants in DNA base excision repair, BRCA1 interacting and growth factor genes.27
196921682010Genetic susceptibility to distinct bladder cancer subphenotypes.25
199962862010ZBRK1 acts as a metastatic suppressor by directly regulating MMP9 in cervical cancer.23
145172992003Degradation of transcription repressor ZBRK1 through the ubiquitin-proteasome pathway relieves repression of Gadd45a upon DNA damage.21

Citation

Dessen P

ZNF350 (zinc finger protein 350)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42880/znf350