ZNF395 (zinc finger protein 395)

2009-02-01  

Identity

HGNC
ZNF395
LOCATION
8p21.1
LOCUSID
55893
ALIAS
HDBP-2,HDBP2,HDRF-2,PBF,PRF-1,PRF1,Si-1-8-14
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55893
MIM: 609494
HGNC: 18737
Ensembl: ENSG00000186918

Variants:

dbSNP: 55893
ClinVar: 55893
TCGA: ENSG00000186918
COSMIC: ZNF395

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186918ENST00000344423Q9H8N7
ENSG00000186918ENST00000517459A0A0C4DGD9
ENSG00000186918ENST00000520290E5RGF1
ENSG00000186918ENST00000520535H0YAN1
ENSG00000186918ENST00000521185E5RG59
ENSG00000186918ENST00000521912E5RFV4
ENSG00000186918ENST00000522795E5RH90
ENSG00000186918ENST00000523095Q9H8N7
ENSG00000186918ENST00000523202Q9H8N7

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
237602072013Emerging roles of zinc finger proteins in regulating adipogenesis.25
190187582009Scythe/BAT3 regulates apoptotic cell death induced by papillomavirus binding factor in human osteosarcoma.24
288938002017VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma.24
152893532004Identification of human autologous cytotoxic T-lymphocyte-defined osteosarcoma gene that encodes a transcriptional regulator, papillomavirus binding factor.20
146252782004Novel nuclear shuttle proteins, HDBP1 and HDBP2, bind to neuronal cell-specific cis-regulatory element in the promoter for the human Huntington's disease gene.19
231420272013Identification of ZNF395 as a novel modulator of adipogenesis.13
240863952013The hypoxia-inducible transcription factor ZNF395 is controlled by IĸB kinase-signaling and activates genes involved in the innate immune response and cancer.12
245990082014MiR-525-3p enhances the migration and invasion of liver cancer cells by downregulating ZNF395.12
178976152007Papillomavirus binding factor binds to SAP30 and represses transcription via recruitment of the HDAC1 co-repressor complex.9
175311902007Papillomavirus binding factor (PBF)-mediated inhibition of cell growth is regulated by 14-3-3beta.8

Citation

Dessen P

ZNF395 (zinc finger protein 395)

Atlas Genet Cytogenet Oncol Haematol. 2009-02-01

Online version: http://atlasgeneticsoncology.org/gene/50674/znf395