ZNF746 (zinc finger protein 746)

2014-09-01  

Identity

HGNC
LOCATION
7q36.1
LOCUSID
ALIAS
PARIS
FUSION GENES

Other Information

Locus ID:

NCBI: 155061
MIM: 613914
HGNC: 21948
Ensembl: ENSG00000181220

Variants:

dbSNP: 155061
ClinVar: 155061
TCGA: ENSG00000181220
COSMIC: ZNF746

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000181220ENST00000340622Q6NUN9
ENSG00000181220ENST00000458143Q6NUN9
ENSG00000181220ENST00000461958C9JNZ9
ENSG00000181220ENST00000644635A0A2R8YDQ5

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
213762322011PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease.341
263249252015Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration.56
296285062018Zinc finger protein 746 promotes colorectal cancer progression via c-Myc stability mediated by glycogen synthase kinase 3β and F-box and WD repeat domain-containing 7.9
241459592014Inhibition of ZNF746 suppresses invasion and epithelial to mesenchymal transition in H460 non-small cell lung cancer cells.5
312379442019Parkin interacting substrate zinc finger protein 746 is a pathological mediator in Parkinson's disease.3
270868512016SUMOylation of the KRAB zinc-finger transcription factor PARIS/ZNF746 regulates its transcriptional activity.2

Citation

Dessen P

ZNF746 (zinc finger protein 746)

Atlas Genet Cytogenet Oncol Haematol. 2014-09-01

Online version: http://atlasgeneticsoncology.org/gene/54866/znf746