ZP4 (zona pellucida glycoprotein 4)

2016-10-01  

Identity

HGNC
LOCATION
1q43
LOCUSID
ALIAS
ZBP,ZP1,ZPB,Zp-4

Other Information

Locus ID:

NCBI: 57829
MIM: 613514
HGNC: 15770
Ensembl: ENSG00000116996

Variants:

dbSNP: 57829
ClinVar: 57829
TCGA: ENSG00000116996
COSMIC: ZP4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116996ENST00000366570Q12836
ENSG00000116996ENST00000611898Q12836

Expression (GTEx)

0
1

Pathways

PathwaySourceExternal ID
ReproductionREACTOMER-HSA-1474165
FertilizationREACTOMER-HSA-1187000
Interaction With The Zona PellucidaREACTOMER-HSA-1300644

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
196256182009Three susceptible loci associated with primary open-angle glaucoma identified by genome-wide association study in a Japanese population.41
186677502008Effects of native human zona pellucida glycoproteins 3 and 4 on acrosome reaction and zona pellucida binding of human spermatozoa.17
164075012006Biological effects of recombinant human zona pellucida proteins on sperm function.12
158051452005Baculovirus-expressed recombinant human zona pellucida glycoprotein-B induces acrosomal exocytosis in capacitated spermatozoa in addition to zona pellucida glycoprotein-C.10
211730712011Human ZP4 is not sufficient for taxon-specific sperm recognition of the zona pellucida in transgenic mice.10
159506512005Binding of recombinant human proacrosin/acrosin to zona pellucida (ZP) glycoproteins. I. Studies with recombinant human ZPA, ZPB, and ZPC.5
257400672015Study on the zona pellucida 4 (ZP4) gene sequence and its expression in the ovaries of patients with polycystic ovary syndrome.5
190045052009DNA vaccine encoding chimeric protein encompassing epitopes of human ZP3 and ZP4: immunogenicity and characterization of antibodies.4
196260402009Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis.3

Citation

Dessen P

ZP4 (zona pellucida glycoprotein 4)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56229/zp4