ZRANB3 (zinc finger RANBP2-type containing 3)

2012-09-01  

Identity

HGNC
ZRANB3
LOCATION
2q21.3
LOCUSID
84083
ALIAS
4933425L19Rik,AH2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84083
MIM: 615655
HGNC: 25249
Ensembl: ENSG00000121988

Variants:

dbSNP: 84083
ClinVar: 84083
TCGA: ENSG00000121988
COSMIC: ZRANB3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000121988ENST00000264159Q5FWF4
ENSG00000121988ENST00000401392Q5FWF4
ENSG00000121988ENST00000403017F8WCT9
ENSG00000121988ENST00000536680F5GYN7
ENSG00000121988ENST00000619650Q5FWF4

Expression (GTEx)

0
1
2
3
4
5
6
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
227045582012Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress.107
290539592017Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers.64
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
227053702012The HARP-like domain-containing protein AH2/ZRANB3 binds to PCNA and participates in cellular response to replication stress.52
288863372017Replication Fork Slowing and Reversal upon DNA Damage Require PCNA Polyubiquitination and ZRANB3 DNA Translocase Activity.52
227596342012ZRANB3 is a structure-specific ATP-dependent endonuclease involved in replication stress response.42
289545492017Functions of SMARCAL1, ZRANB3, and HLTF in maintaining genome stability.30
210789622010Annealing helicase 2 (AH2), a DNA-rewinding motor with an HNH motif.26
286213052017Structural insights into the function of ZRANB3 in replication stress response.21
268843332016Identification of a Substrate Recognition Domain in the Replication Stress Response Protein Zinc Finger Ran-binding Domain-containing Protein 3 (ZRANB3).9

Citation

Dessen P

ZRANB3 (zinc finger RANBP2-type containing 3)

Atlas Genet Cytogenet Oncol Haematol. 2012-09-01

Online version: http://atlasgeneticsoncology.org/gene/52879/zranb3