ZWINT (ZW10 interacting kinetochore protein)

2006-10-01 Affiliation

Identity

HGNC

ZWINT

LOCATION

10q21.1

LOCUSID

11130

ALIAS

HZwint-1,KNTC2AP,SIP30,ZWINT1

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 11130
MIM: 609177
HGNC: 13195
Ensembl: ENSG00000122952

Variants:

dbSNP: 11130
ClinVar: 11130
TCGA: ENSG00000122952
COSMIC: ZWINT

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000122952	ENST00000318387	A6NH27
ENSG00000122952	ENST00000361148	O95229
ENSG00000122952	ENST00000373944	O95229
ENSG00000122952	ENST00000395405	O95229
ENSG00000122952	ENST00000489649	R4GMS7

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Signal Transduction	REACTOME	R-HSA-162582
Signaling by Rho GTPases	REACTOME	R-HSA-194315
RHO GTPase Effectors	REACTOME	R-HSA-195258
RHO GTPases Activate Formins	REACTOME	R-HSA-5663220
Cell Cycle	REACTOME	R-HSA-1640170
Cell Cycle, Mitotic	REACTOME	R-HSA-69278
M Phase	REACTOME	R-HSA-68886
Mitotic Prometaphase	REACTOME	R-HSA-68877
Resolution of Sister Chromatid Cohesion	REACTOME	R-HSA-2500257
Mitotic Metaphase and Anaphase	REACTOME	R-HSA-2555396
Mitotic Anaphase	REACTOME	R-HSA-68882
Separation of Sister Chromatids	REACTOME	R-HSA-2467813

References

Pubmed ID	Year	Title	Citations
15485811	2004	Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling.	52
18268100	2008	Stable hZW10 kinetochore residency, mediated by hZwint-1 interaction, is essential for the mitotic checkpoint.	31
21775627	2011	Zwint-1 is a novel Aurora B substrate required for the assembly of a dynein-binding platform on kinetochores.	24
22023800	2012	Terf/TRIM17 stimulates degradation of kinetochore protein ZWINT and regulates cell proliferation.	20
17373700	2007	Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease.	15
26486467	2015	Zwint-1 is required for spindle assembly checkpoint function and kinetochore-microtubule attachment during oocyte meiosis.	14
19008095	2009	Single nucleotide polymorphisms in chromosomal instability genes and risk and clinical outcome of breast cancer: a Swedish prospective case-control study.	12
21345172	2011	hZwint-1 bridges the inner and outer kinetochore: identification of the kinetochore localization domain and the hZw10-interaction domain.	7
30198401	2018	Decreased Expression of ZWINT is Associated With Poor Prognosis in Patients With HCC After Surgery.	7
30643969	2019	ZWINT is the next potential target for lung cancer therapy.	5

Citation

Dessen P

ZWINT (ZW10 interacting kinetochore protein)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43562/zwint