HSPH1 (heat shock 105kDa/110kDa protein 1)

Identity

Other names	HSP105alpha
	HSP105beta
	HSP110
	HSP105
	KIAA0201
	NY-CO-25
HGNC	HSPH1
Location	13q12.3
Location_base_pair	Starts at 30608763 and ends at 30634117 bp from pter ( according to hg18-Mar_2006).

DNA/RNA

	Genomic organization of the mouse HSP105 gene. The linear map of the exon-intron structure is shown schematically. Exons are represented as numbered boxes. Two alternative splicing patterns gave rise to HSP105alpha and HSP105beta transcripts. ATG and TAG indicate the positions of initiation and termination codons, respectively. (DDBJ/EMBL/GenBank DNA databases with accession Nos. AB005267-AB005282).
Description	18 exons on 22 kb
Transcription	Hsp105alpha is transcribed constitutively and also by a variety of stresses. 4 kb mRNA Hsp105beta is an alternative spliced isoform only produced during heat shock at 42 degree.

Protein

	Shematic structures of HSP105alpha and HSP105beta proteins. Shaded box represents the spliced out region of HSP105alpha which is lacking in HSP105beta.
Description	Hsp105alpha: 858 amino acids, 105 kDa; contains an ATP binding domain (residues 1-383), b-sheet domain (residues 384-511), loop domain (residues 512-607) and alpha-helix domain (residues 608-858). Hsp105beta: 814 amino acids, 90 kDa; contains an ATP binding domain (residues 1-383), b-sheet domain (residues 384-511), loop domain (residues 512-563) and alpha-helix domain (residues 564-814).
Expression	wide, highly expressed in brain
Localisation	Hsp105alpha, cytoplasmic; Hsp105beta, nuclear
Function	Hsp105alpha and Hsp105beta suppress the aggregation of denatured proteins; function as a substitute for Hsp70 family proteins to suppress the aggregation of denatured proteins in cells under severe stress; regulate substrate binding cycle of Hsp70/Hsc70 by inhibiting the ATPase activity of Hsp70/Hsc70.
Homology	With mouse apg-1, mouse apg-2, sea urchin egg receptor, C. elegans 86.9-kDa protein, A. thaliana hsp91 and S. cerevisiae SSE1, human hsp70 and human hsc70.

Implicated in

Entity	Lung cancers
Prognosis	Poor
Oncogenesis	Low expression of hsp105 was identified as predictors of survival in lung adenocarcinomas.
Entity	Colorectal cancers
Prognosis	Survival is not much more than 50% after 5 years.
Oncogenesis	Overexpression of hsp105 is a late event in the colorectal adenoma-carcinoma sequence.

External links

	Nomenclature
HGNC	HSPH1   16969
Entrez_Gene	HSPH1  10808  heat shock 105kDa/110kDa protein 1
	Cards
Atlas	HSPH1ID40891ch13q12
GeneCards	HSPH1
Ensembl	HSPH1 [Search_View]   ENSG00000120694 [Gene_View]  HSPH1 [Vega]
Genatlas	HSPH1
GeneLynx	HSPH1
eGenome	HSPH1
euGene	10808
	Genomic and cartography
GoldenPath	HSPH1  -  13q12.3   chr13:30608763-30634117 -  13q12.3   [Description]    (hg18-Mar_2006)
Ensembl	HSPH1 - 13q12.3 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	HSPH1
	Gene and transcription
Genbank	AB003333 [ ENTREZ ]
Genbank	AB003334 [ ENTREZ ]
Genbank	AF039695 [ ENTREZ ]
Genbank	AK293955 [ ENTREZ ]
Genbank	AK302294 [ ENTREZ ]
RefSeq	NM_006644 [ SRS ]    NM_006644 [ ENTREZ ]
RefSeq	AC_000056 [ SRS ]    AC_000056 [ ENTREZ ]
RefSeq	AC_000145 [ SRS ]    AC_000145 [ ENTREZ ]
RefSeq	NC_000013 [ SRS ]    NC_000013 [ ENTREZ ]
RefSeq	NT_024524 [ SRS ]    NT_024524 [ ENTREZ ]
RefSeq	NW_001838072 [ SRS ]    NW_001838072 [ ENTREZ ]
RefSeq	NW_925473 [ SRS ]    NW_925473 [ ENTREZ ]
CCDS	HSPH1 CCDS - NCBI
AceView	HSPH1 AceView - NCBI
Unigene	Hs.36927 [ SRS ]    Hs.36927 [ NCBI ]     HS36927 [ spliceNest ]
Fast-db	2467 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q92598 [ SRS]    Q92598 [ EXPASY ]     Q92598 [ INTERPRO ]     Q92598 [ UNIPROT ] Q92598 [ VarSplice ]
Prosite	PS00297 HSP70_1 [ SRS ]    PS00297 HSP70_1 [ Expasy ]
Prosite	PS00329 HSP70_2 [ SRS ]    PS00329 HSP70_2 [ Expasy ]
Prosite	PS01036 HSP70_3 [ SRS ]    PS01036 HSP70_3 [ Expasy ]
Interpro	IPR001023 Hsp70 [ SRS ]    IPR001023 Hsp70 [ EBI ]
Interpro	IPR013126 Hsp_70 [ SRS ]    IPR013126 Hsp_70 [ EBI ]
CluSTr	Q92598
Pfam	PF00012 HSP70 [ SRS ]    PF00012 HSP70 [ Sanger ]    pfam00012 [ NCBI-CDD ]
Prodom	PD000089 Hsp70[INRA-Toulouse]
Prodom	Q92598 HS105_HUMAN [ Domain structure ]   Q92598 HS105_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	Q92598
HPRD	09990
	Protein Interaction databases
DIP	Q92598
IntAct	Q92598
	Polymorphism : SNP, mutations, diseases
OMIM	610703    [ map ]
GENECLINICS	610703
SNP	HSPH1 [dbSNP-NCBI]
SNP	NM_006644 [SNP-NCI]
SNP	HSPH1 [GeneSNPs - Utah]  HSPH1] [HGBASE - SRS]
HAPMAP	HSPH1 [HAPMAP]
HGMD	HSPH1
Genetic Association	HSPH1
CDC HuGE	HSPH1
	General knowledge
Family Browser	HSPH1 [UCSC Family Browser]
SOURCE	NM_006644
SMD	Hs.36927
SAGE	Hs.36927
GO	nucleotide binding [Amigo]  nucleotide binding
GO	ATP binding [Amigo]  ATP binding
GO	cytoplasm [Amigo]  cytoplasm
GO	response to unfolded protein [Amigo]  response to unfolded protein
PubGene	HSPH1
TreeFam	HSPH1
CTD	10808 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	HSPH1 Related clones (RZPD - Berlin)
	PubMed
PubMed	24 Pubmed reference(s) in Entrez

Bibliography

Cloning and expression of murine high molecular mass heat shock proteins, HSP105.

Yasuda K, Nakai A, Hatayama T, Nagata K

The Journal of biological chemistry. 1995 ; 270 (50) : 29718-29723.

PMID 8530361

Molecular cloning, expression and localization of human 105 kDa heat shock protein, hsp105.

Ishihara K, Yasuda K, Hatayama T

Biochimica et biophysica acta. 1999 ; 1444 (1) : 138-142.

PMID 9931472

Genomic cloning and promoter analysis of the mouse 105-kDa heat shock protein (HSP105) gene.

Yasuda K, Ishihara K, Nakashima K, Hatayama T

Biochemical and biophysical research communications. 1999 ; 256 (1) : 75-80.

PMID 10066425

Gene cloning of immunogenic antigens overexpressed in pancreatic cancer.

Nakatsura T, Senju S, Yamada K, Jotsuka T, Ogawa M, Nishimura Y

Biochemical and biophysical research communications. 2001 ; 281 (4) : 936-944.

PMID 11237751

Gene cloning of immunogenic antigens overexpressed in pancreatic cancer.

Nakatsura T, Senju S, Yamada K, Jotsuka T, Ogawa M, Nishimura Y

Biochemical and biophysical research communications. 2001 ; 281 (4) : 936-944.

PMID 11237751

Heat shock protein 105 is overexpressed in a variety of human tumors.

Kai M, Nakatsura T, Egami H, Senju S, Nishimura Y, Ogawa M

Oncology reports. 2003 ; 10 (6) : 1777-1782.

PMID 14534695

Hsp105 but not Hsp70 family proteins suppress the aggregation of heat-denatured protein in the presence of ADP.

Yamagishi N, Ishihara K, Saito Y, Hatayama T

FEBS letters. 2003 ; 555 (2) : 390-396.

PMID 14644449

Hsp105 but not Hsp70 family proteins suppress the aggregation of heat-denatured protein in the presence of ADP.

Yamagishi N, Ishihara K, Saito Y, Hatayama T

FEBS letters. 2003 ; 555 (2) : 390-396.

PMID 14644449

DNA vaccination of HSP105 leads to tumor rejection of colorectal cancer and melanoma in mice through activation of both CD4 T cells and CD8 T cells.

Miyazaki M, Nakatsura T, Yokomine K, Senju S, Monji M, Hosaka S, Komori H, Yoshitake Y, Motomura Y, Minohara M, Kubo T, Ishihara K, Hatayama T, Ogawa M, Nishimura Y

Cancer science. 2005 ; 96 (10) : 695-705.

PMID 16232202

Hsp105 family proteins suppress staurosporine-induced apoptosis by inhibiting the translocation of Bax to mitochondria in HeLa cells.

Yamagishi N, Ishihara K, Saito Y, Hatayama T

Experimental cell research. 2006 ; 312 (17) : 3215-3223.

PMID 16857185

Synthetic small interfering RNA targeting heat shock protein 105 induces apoptosis of various cancer cells both in vitro and in vivo.

Hosaka S, Nakatsura T, Tsukamoto H, Hatayama T, Baba H, Nishimura Y

Cancer science. 2006 ; 97 (7) : 623-632.

PMID 16827803

Heat shock protein 105 is overexpressed in squamous cell carcinoma and extramammary Paget disease but not in basal cell carcinoma.

Muchemwa FC, Nakatsura T, Ihn H, Kageshita T

The British journal of dermatology. 2006 ; 155 (3) : 582-585.

PMID 16911285

alpha%5BTI%5D%20OR%20HSP105beta%5BTI%5D%20OR%20HSP110%5BTI%5D%20OR%20HSP105%5BTI%5D%20OR%20KIAA0201%5BTI%5D%20OR%20NY-CO-25%5BTI%5D%20)%20AND%20REVIEW%5BPT%5D%20AND%20ENGLISH%5BLA%5D&field=titl&dispmax=50>REVIEW articles	automatic search in PubMed
alpha%5BTI%5D%20OR%20HSP105beta%5BTI%5D%20OR%20HSP110%5BTI%5D%20OR%20HSP105%5BTI%5D%20OR%20KIAA0201%5BTI%5D%20OR%20NY-CO-25%5BTI%5D%20)%20AND%20(2006%5BDP%5D%20OR%202007%20OR%202008%5BDP%5D)&field=titl&dispmax=50>Last year publications	automatic search in PubMed

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Contributor(s)

Written	02-2007	Takumi Hatayama, Nobuyuki Yamagishi

Citation

This paper should be referenced as such :

Hatayama T, Yamagishi N . HSPH1 (heat shock 105kDa/110kDa protein 1). Atlas Genet Cytogenet Oncol Haematol. February 2007 . URL : http://AtlasGeneticsOncology.org/Genes/HSPH1ID40891ch13q12.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sun Nov 9 19:41:49 2008