ITK (IL2-inducible T-cell kinase)
2007-04-01 Berthold Streubel AffiliationDepartment of Pathology, Medical University of Vienna, Waehringer, Guertel 18-20, A-1090 Vienna, Austria
Identity
HGNC
LOCATION
5q33.3
LOCUSID
ALIAS
EMT,LPFS1,LYK,PSCTK2
FUSION GENES
DNA/RNA
Description
centromere to telomere orientation; Exons: 17
Transcription
Transcript length: 4,419 bps
Proteins
ITK protein
Description
Number of residues: 620 residues; Molecular weight: 71 kDa; Conserved domains: PH-Tec, Tec pleckstrin homology (PH) domain; BTK, Brutons tyrosine kinase Cys-rich motif; SH3, Src homology 3 domains; SH2, Src homology 2 domains; TyrKc, Tyrosine kinase, catalytic domain.
Function
Although originally described as an important component of proximal TCR signaling pathways, the Tec family tyrosine kinase Itk has become increasingly recognized for its important role in regulating T-helper-cell differentiation. Itk has a crucial role in Th2 responses, both the protective responses to pathogenic infections in addition to the pathological responses resulting in allergic asthma. Itk is not required for Th2 differentiation per se, but effector Th2 cytokine production during recall responses is severely impaired in the absence of Itk.
Implicated in
Entity name
Disease
peripheral T-cell lymphomas, unspecified (PTCL-u). ITK-SYK transcripts were detected in 5 of 30 (17%) unspecified peripheral T-cell lymphomas, but not in cases of angioimmunoblastic T-cell lymphoma (n=9) and ALK-negative anaplastic large cell lymphoma (n=7)
Hybrid gene
N-terminal pleckstrin homology domain and proline-rich region of ITK fused to the tyrosine kinase domain of SYK.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 8985255 | 1997 | Regulatory intramolecular association in a tyrosine kinase of the Tec family. | Andreotti AH et al |
| 11406363 | 2001 | Tec kinases: modulators of lymphocyte signaling and development. | Lewis CM et al |
| 8777721 | 1995 | Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk. | Liao XC et al |
| 9584150 | 1998 | T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells. | Liu KQ et al |
| 10213685 | 1999 | Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity. | Schaeffer EM et al |
| 16341044 | 2006 | Novel t(5;9)(q33;q22) fuses ITK to SYK in unspecified peripheral T-cell lymphoma. | Streubel B et al |
| 10795735 | 2000 | Tec kinases: a family with multiple roles in immunity. | Yang WC et al |
Other Information
Locus ID:
NCBI: 3702
MIM: 186973
HGNC: 6171
Ensembl: ENSG00000113263
Variants:
dbSNP: 3702
ClinVar: 3702
TCGA: ENSG00000113263
COSMIC: ITK
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000113263 | ENST00000422843 | Q08881 |
| ENSG00000113263 | ENST00000517779 | E5RJY4 |
| ENSG00000113263 | ENST00000521769 | E5RFR5 |
Expression (GTEx)
Pathways
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36326697 | 2023 | Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculosis. | 5 |
| 37992572 | 2023 | Targeting kinase ITK treats autoimmune arthritis via orchestrating T cell differentiation and function. | 2 |
| 36326697 | 2023 | Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculosis. | 5 |
| 37992572 | 2023 | Targeting kinase ITK treats autoimmune arthritis via orchestrating T cell differentiation and function. | 2 |
| 35210549 | 2022 | ITK independent development of Th17 responses during hypersensitivity pneumonitis driven lung inflammation. | 1 |
| 35210549 | 2022 | ITK independent development of Th17 responses during hypersensitivity pneumonitis driven lung inflammation. | 1 |
| 32628964 | 2021 | ITK deficiency presenting as autoimmune lymphoproliferative syndrome. | 5 |
| 32640487 | 2021 | BTK/ITK dual inhibitors: Modulating immunopathology and lymphopenia for COVID-19 therapy. | 19 |
| 33931484 | 2021 | Itk Promotes the Integration of TCR and CD28 Costimulation through Its Direct Substrates SLP-76 and Gads. | 7 |
| 34282055 | 2021 | Interleukin-2 inducible T-cell kinase: a potential prognostic biomarker and tumor microenvironment remodeling indicator for hepatocellular carcinoma. | 1 |
| 34702300 | 2021 | Cytotoxic lymphocytes-related gene ITK from a systematic CRISPR screen could predict prognosis of ovarian cancer patients with distant metastasis. | 2 |
| 32628964 | 2021 | ITK deficiency presenting as autoimmune lymphoproliferative syndrome. | 5 |
| 32640487 | 2021 | BTK/ITK dual inhibitors: Modulating immunopathology and lymphopenia for COVID-19 therapy. | 19 |
| 33931484 | 2021 | Itk Promotes the Integration of TCR and CD28 Costimulation through Its Direct Substrates SLP-76 and Gads. | 7 |
| 34282055 | 2021 | Interleukin-2 inducible T-cell kinase: a potential prognostic biomarker and tumor microenvironment remodeling indicator for hepatocellular carcinoma. | 1 |
Citation
Berthold Streubel
ITK (IL2-inducible T-cell kinase)
Atlas Genet Cytogenet Oncol Haematol. 2007-04-01
Online version: http://atlasgeneticsoncology.org/gene/43329/itk
