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JAK2 (janus kinase 2)

Identity

HGNC (Hugo) JAK2
Location 9p24
Location_base_pair Starts at 4975245 and ends at 5118182 bp from pter ( according to hg18-Mar_2006)  [Mapping]
 
  JAK2 (9p24) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics. Laboratories willing to validate the probes are welcome : contact rocchi@biologia.uniba.it

DNA/RNA

Description 25 exons spanning roughly 140 kb of genomic DNA; 5402 bp pre-mRNA; 6 different transcripts, putatively encoding 4 different protein isoforms

Protein

Description 1132 amino acids; 130,7 kDa; JAK2 contains a central Src homology 2 (SH2) domain, and two C-terminal domains: a tyrosine kinase domain JH1 (also termed PTK or TyrKc domain), and a tyrosine kinase-like domain JH2 (also termed STYKc)
Expression wide
Localisation intracellular, possibly membrane associated
Function protein tyrosine kinase of the non-receptor type that associates with the intracellular domains of cytokine receptors; JAK2 is the predominant JAK kinase activated in response to several growth factors and cytokines such as IL-3, GM-CSF and erythropoietin; it has been found to be constitutively associated with the prolactin receptor and is required for responses to gamma interferon
Homology JAK2 belongs to the janus kinase subfamily; so far four mammalian JAKs have been identified (JAK1, JAK2, JAK3, and TYK2); human JAK2 is > 90% identical to the mouse and the rat JAK2 homologs.

Mutations

Somatic A high proportion (> 50%) of patients with myeloproliferative disorders (MPD; (polycythemia vera, essential thrombocythemia, idiopathic myelofibrosis - see below) carry a dominant gain-of-function V617F mutation in the JH2 kinase-like domain of JAK2. This mutation leads to deregulation of the kinase activity, and thus to constitutive tyrosine phosphorylation activity. The incidence of the V617F mutation in different studies ranges from 65-97% in polycythemia vera, from 41-57% in patients with essential thrombocythemia, and from 23-95% in patients with idiopathic myelofibrosis. In MPD the mutation is heterozygous in most patients and homozygous only in a minor subset. Mitotic recombination probably causes both 9p LOH and the transition from heterozygosity to homozygosity. The same mutation was also found in roughly 20% of Ph-negative atypical CML, in more than 10% of CMML, in about 15% of patients with megakaryocytic AML (AML M7), and 1/5 patients with juvenile myelomonocytic leukemia (JMML). The V617F mutation seems to occur exclusively in hematopietic malignancies of the myeloid lineage.

Implicated in

Entity t(8;9)(p21-22;p24) / acute leukaemias -- > PCM1-JAK2
Disease myeloid and lymphoid malignancies; predominantly atypical CML, but also found in (CEL), (secondary) AML, and MDS/MPD; thirteen cases described to date, all male, except for one childhood female case with erythroid leukemia with multiple bone tumors
Prognosis highly variable; allogeneic stem cell transplantation may be the only curative treatment
Hybrid/Mutated Gene 5¹ PCM1 ­ 3¹ JAK2; only in some cases the reciprocal 5¹ JAK2 ­ 3¹ PCM1 is present
Abnormal Protein almost the entire PCM1 protein containing multiple coiled-coil domains is fused to the tyrosine kinase C-terminal domains (JH2 and JH1) of JAK2
Oncogenesis dimerization or oligomerization of the PCM1-JAK2 chimera through one or more of the coiled-coil motifs of PCM1 probably results in the constitutive activation of the tyrosine kinase domain of JAK2
  
Entity t(9;12)(p24;p13) / acute leukaemias --> JAK2/ETV6
Disease myeloid and lymphoid leukemias; only three cases described to date; one case each: childhood T-ALL, pre B-ALL, atypical CML
Prognosis unknown
Hybrid/Mutated Gene 5' ETV6 - 3' JAK2
Abnormal Protein in the atypical CML the N-terminal HLH of ETV6 is fused to the tyrosine kinase C-terminal domains (JH2 and JH1) of JAK2; in the B-ALL the same ETV6 domain is fused to part of the JH2 and the complete JH1 domain, and in the T-ALL case to the JH1 domain
Oncogenesis it may be speculated that the HLH domain of ETV6 provides a dimerization interface to the kinase domain of JAK2, which activates JAK2; ETV6-JAK2 transgenic mice ­ generated using a T-ALL specific fusion construct - develop fatal CD8+ acute T-cell leukemia
  
Entity t(9;22)(p24;q11.2) /MPD-- > JAK2-BCR
Disease atypical CML; only one case described to date
Hybrid/Mutated Gene 5¹ BCR ­ 3¹ JAK2; absence of the reciprocal 5¹ JAK2 ­ 3¹ BCR
Abnormal Protein the N-terminal coiled-coil domain of BCR is fused to the JH1 tyrosine kinase C-terminal domain of JAK2
Oncogenesis constitutive activation of the tyrosine kinase domain of JAK2 mediated through oligomerization through the coiled-coil domain of BCR
  
Entity Polycythemia vera / Essential thrombocythemia / Idiopathic thrombocythemia / Idiopathic myelofibrosis
Note the V617F mutation in JAK2 could form the basis for a new molecular classification of myeloproliferative disorders
Disease chronic myeloproliferative syndromes
Oncogenesis a significant percentage of patients with myeloproliferative disorders carries a dominant gain of function V617F mutation in JAK2; this mutation seems to lead to deregulation of the kinase activity of JAK2, and thus to constitutive tyrosine phosphorylation activity, providing hematopoietic cells with a proliferative and survival advantage
  

Breakpoints

 

External links

Nomenclature
HGNC (Hugo)JAK2   6192
Entrez_Gene (NCBI)JAK2  3717  Janus kinase 2 (a protein tyrosine kinase)
Cards
AtlasJAK98
GeneCards (Weizmann)JAK2
Ensembl (Hinxton)ENSG00000096968 [Gene_View]  JAK2 [Vega]
AceView (NCBI)JAK2
Genatlas (Paris)JAK2
euGene (Indiana)3717
SOURCE (Stanford)NM_004972
Genomic and cartography
GoldenPath (UCSC)JAK2  -  9p24   chr9:4975245-5118182 +  9p24   [Description]    (hg18-Mar_2006)
EnsemblJAK2 - 9p24 [CytoView]
Mapping of homologs : NCBIJAK2 [Mapview]
OMIM147796   187950   254450   263300   600880   601626   
Gene and transcription
Gene : Genbank (Entrez)AF001362 AF005216 AF058925 AK292525 AK302618
Reference sequence (RefSeq transcript) :SRSNM_004972
Reference transcript : EntrezNM_004972
RefSeq genomic : SRSAC_000052 AC_000141 NC_000009 NT_008413 NW_001839149 NW_924062
RefSeq genomic : EntrezAC_000052 AC_000141 NC_000009 NT_008413 NW_001839149 NW_924062
Consensus coding sequences : CCDS NCBIJAK2
Cluster EST : UnigeneHs.656213 [ SRS ] Hs.656213 [ NCBI ]
Alternative Splicing : Fast-db (Paris)1664
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtO60674 (SRS) O60674 (Expasy) O60674 (Uniprot)
With graphics : InterProO60674
Splice isoforms : VarSplice FASTAO60674(VarSplice FASTA)
Domaine pattern : Prosite (SRS)FERM_1 (PS00660)    FERM_2 (PS00661)    FERM_3 (PS50057)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    SH2 (PS50001)   
Domain pattern : Prosite (Expaxy)FERM_1 (PS00660)    FERM_2 (PS00661)    FERM_3 (PS50057)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    SH2 (PS50001)   
Domains : Interpro (SRS)Band_4.1_N    JAK    JAK2    Prot_kinase_core    Protein_kinase_ATP_bd_CS    SH2    Tyr_pkinase    Tyr_pkinase_AS    TyrPK_Jak   
Domains : Interpro (EBI)Band_4.1_N    JAK    JAK2    Prot_kinase_core    Protein_kinase_ATP_bd_CS    SH2    Tyr_pkinase    Tyr_pkinase_AS    TyrPK_Jak   
Related proteins : CluSTrO60674
Domain families : Pfam SRSPkinase_Tyr (PF07714)    SH2 (PF00017)   
Domain families : Pfam SangerPkinase_Tyr (PF07714)    SH2 (PF00017)   
Domain families : Pfam NCBIpfam07714    pfam00017   
Domain families : Smart EMBLB41 (SM00295)SH2 (SM00252)TyrKc (SM00219)
Domain structure : Prodom (Prabi Lyon)Prot_kinase (PD000001)    (PD000001)   
Blocks (Seattle)O60674
Crystal structure of protein : PDB SRS2B7A   
Crystal structure of protein : PDBSum2B7A   
Crystal structure of protein : IMB2B7A   
Crystal structure of protein : PDB RSDB2B7A   
HPRD00993
Protein Interaction databases
DIP (DOE-UCLA)O60674
IntAct (EBI)O60674
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBIJAK2
SNP : GeneSNP UtahJAK2
SNP : HGBaseJAK2
Genetic variants : HAPMAPJAK2
Somatic Mutations in Cancer : COSMICJAK2 
Translocation Breakpoints in Cancer : TICdbJAK2 
Mutations and Diseases : HGMDJAK2
Hereditary diseases : OMIM147796    187950    254450    263300    600880    601626   
Hereditary diseases : GENETests147796    187950    254450    263300    600880    601626   
Diseases : Genetic AssociationJAK2
General knowledge
Homologs : HomoloGeneJAK2
Homology/Alignments : Family Browser UCSCJAK2
Phylogenetic Trees/Animal Genes : TreeFamJAK2
Catalytic activity : Enzyme2.7.10.2 [ Enzyme-Expasy ]   2.7.10.2 [ Enzyme-SRS ]   2.7.10.2 [ IntEnz-EBI ]   2.7.10.2 [ BRENDA ]   2.7.10.2 [ KEGG ]   
Chemical/Protein Interactions : CTD3717
Keywords Ontology : AmiGOnucleotide binding  non-membrane spanning protein tyrosine kinase activity  Janus kinase activity  receptor binding  growth hormone receptor binding  interleukin-12 receptor binding  ATP binding  nucleus  cytoplasm  cytoskeleton  caveola  apoptosis  cell motion  enzyme linked receptor protein signaling pathway  tyrosine phosphorylation of STAT protein  STAT protein nuclear translocation  mesoderm development  negative regulation of cell proliferation  endomembrane system  membrane  transferase activity  myeloid cell differentiation  SH2 domain binding  positive regulation of tyrosine phosphorylation of Stat3 protein  positive regulation of tyrosine phosphorylation of Stat5 protein  negative regulation of DNA binding  response to antibiotic  
Keywords Ontology : EGO-EBInucleotide binding  non-membrane spanning protein tyrosine kinase activity  Janus kinase activity  receptor binding  growth hormone receptor binding  interleukin-12 receptor binding  ATP binding  nucleus  cytoplasm  cytoskeleton  caveola  apoptosis  cell motion  enzyme linked receptor protein signaling pathway  tyrosine phosphorylation of STAT protein  STAT protein nuclear translocation  mesoderm development  negative regulation of cell proliferation  endomembrane system  membrane  transferase activity  myeloid cell differentiation  SH2 domain binding  positive regulation of tyrosine phosphorylation of Stat3 protein  positive regulation of tyrosine phosphorylation of Stat5 protein  negative regulation of DNA binding  response to antibiotic  
Pathways : BIOCARTAIL12 and Stat4 Dependent Signaling Pathway in Th1 Development [Genes]    TPO Signaling Pathway [Genes]    Bioactive Peptide Induced Signaling Pathway [Genes]    EPO Signaling Pathway [Genes]    Erythropoietin mediated neuroprotection through NF-kB [Genes]    Growth Hormone Signaling Pathway [Genes]    Inhibition of Cellular Proliferation by Gleevec [Genes]    IFN gamma signaling pathway [Genes]    IL 3 signaling pathway [Genes]    NO2-dependent IL 12 Pathway in NK cells [Genes]    Chaperones modulate interferon Signaling Pathway [Genes]   
Pathways : KEGGJak-STAT signaling pathwayAdipocytokine signaling pathway
Other databases
Probes
ProbeCancer Cytogenetics (Bari)
Probes : ImagenesJAK2 Related clones (RZPD - Berlin)
Literature
PubMed499 Pubmed reference(s) in Entrez
PubGeneJAK2

Bibliography

A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia.
Lacronique V, Boureux A, Valle VD, Poirel H, Quang CT, Mauchauffˆ© M, Berthou C, Lessard M, Berger R, Ghysdael J, Bernard OA
Science (New York, N.Y.). 1997 ; 278 (5341) : 1309-1312.
PMID 9360930
 
Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia.
Peeters P, Raynaud SD, Cools J, Wlodarska I, Grosgeorge J, Philip P, Monpoux F, Van Rompaey L, Baens M, Van den Berghe H, Marynen P
Blood. 1997 ; 90 (7) : 2535-2540.
PMID 9326218
 
Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes.
Schwaller J, Frantsve J, Aster J, Williams IR, Tomasson MH, Ross TS, Peeters P, Van Rompaey L, Van Etten RA, Ilaria R Jr, Marynen P, Gilliland DG
The EMBO journal. 1998 ; 17 (18) : 5321-5333.
PMID 9736611
 
TEL-JAK2 transgenic mice develop T-cell leukemia.
Carron C, Cormier F, Janin A, Lacronique V, Giovannini M, Daniel MT, Bernard O, Ghysdael J
Blood. 2000 ; 95 (12) : 3891-3899.
PMID 10845925
 
TEL-JAK2 constitutively activates the extracellular signal-regulated kinase (ERK), stress-activated protein/Jun kinase (SAPK/JNK), and p38 signaling pathways.
Ho JM, Nguyen MH, Dierov JK, Badger KM, Beattie BK, Tartaro P, Haq R, Zanke BW, Carroll MP, Barber DL
Blood. 2002 ; 100 (4) : 1438-1448.
PMID 12149229
 
Clinical implications of the JAK2 V617F mutation in essential thrombocythemia.
Antonioli E, Guglielmelli P, Pancrazzi A, Bogani C, Verrucci M, Ponziani V, Longo G, Bosi A, Vannucchi AM
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2005 ; 19 (10) : 1847-1849.
PMID 16079890
 
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders.
Baxter EJ, Scott LM, Campbell PJ, East C, Fourouclas N, Swanton S, Vassiliou GS, Bench AJ, Boyd EM, Curtin N, Scott MA, Erber WN, Cancer Genome Project, Green AR
Lancet. 2005 ; 365 (9464) : 1054-1061.
PMID 15781101
 
The t(8;9)(p22;p24) translocation in atypical chronic myeloid leukaemia yields a new PCM1-JAK2 fusion gene.
Bousquet M, Quelen C, De Mas V, Duchayne E, Roquefeuil B, Delsol G, Laurent G, Dastugue N, Brousset P
Oncogene. 2005 ; 24 (48) : 7248-7252.
PMID 16091753
 
Genetics of myeloid malignancies: pathogenetic and clinical implications.
Frˆhling S, Scholl C, Gilliland DG, Levine RL
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2005 ; 23 (26) : 6285-6295.
PMID 16155011
 
The Jak2V617F mutation, PRV-1 overexpression, and EEC formation define a similar cohort of MPD patients.
Goerttler PS, Steimle C, Mˆ§rz E, Johansson PL, Andreasson B, Griesshammer M, Gisslinger H, Heimpel H, Pahl HL
Blood. 2005 ; 106 (8) : 2862-2864.
PMID 15985544
 
A BCR-JAK2 fusion gene as the result of a t(9;22)(p24;q11.2) translocation in a patient with a clinically typical chronic myeloid leukemia.
Griesinger F, Hennig H, Hillmer F, Podleschny M, Steffens R, Pies A, Wˆrmann B, Haase D, Bohlander SK
Genes, chromosomes & cancer. 2005 ; 44 (3) : 329-333.
PMID 16001431
 
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera.
James C, Ugo V, Le Couˆ©dic JP, Staerk J, Delhommeau F, Lacout C, Garˆßon L, Raslova H, Berger R, Bennaceur-Griscelli A, Villeval JL, Constantinescu SN, Casadevall N, Vainchenker W
Nature. 2005 ; 434 (7037) : 1144-1148.
PMID 15793561
 
JAK2 mutation 1849G>T is rare in acute leukemias but can be found in CMML, Philadelphia chromosome-negative CML, and megakaryocytic leukemia.
Jelinek J, Oki Y, Gharibyan V, Bueso-Ramos C, Prchal JT, Verstovsek S, Beran M, Estey E, Kantarjian HM, Issa JP
Blood. 2005 ; 106 (10) : 3370-3373.
PMID 16037387
 
Widespread occurrence of the JAK2 V617F mutation in chronic myeloproliferative disorders.
Jones AV, Kreil S, Zoi K, Waghorn K, Curtis C, Zhang L, Score J, Seear R, Chase AJ, Grand FH, White H, Zoi C, Loukopoulos D, Terpos E, Vervessou EC, Schultheis B, Emig M, Ernst T, Lengfelder E, Hehlmann R, Hochhaus A, Oscier D, Silver RT, Reiter A, Cross NC
Blood. 2005 ; 106 (6) : 2162-2168.
PMID 15920007
 
A gain-of-function mutation of JAK2 in myeloproliferative disorders.
Kralovics R, Passamonti F, Buser AS, Teo SS, Tiedt R, Passweg JR, Tichelli A, Cazzola M, Skoda RC
The New England journal of medicine. 2005 ; 352 (17) : 1779-1790.
PMID 15858187
 
Altered gene expression in myeloproliferative disorders correlates with activation of signaling by the V617F mutation of Jak2.
Kralovics R, Teo SS, Buser AS, Brutsche M, Tiedt R, Tichelli A, Passamonti F, Pietra D, Cazzola M, Skoda RC
Blood. 2005 ; 106 (10) : 3374-3376.
PMID 16081684
 
Mutation studies in CD3+, CD19+ and CD34+ cell fractions in myeloproliferative disorders with homozygous JAK2(V617F) in granulocytes.
Lasho TL, Mesa R, Gilliland DG, Tefferi A
British journal of haematology. 2005 ; 130 (5) : 797-799.
PMID 16115143
 
The JAK2V617F activating mutation occurs in chronic myelomonocytic leukemia and acute myeloid leukemia, but not in acute lymphoblastic leukemia or chronic lymphocytic leukemia.
Levine RL, Loriaux M, Huntly BJ, Loh ML, Beran M, Stoffregen E, Berger R, Clark JJ, Willis SG, Nguyen KT, Flores NJ, Estey E, Gattermann N, Armstrong S, Look AT, Griffin JD, Bernard OA, Heinrich MC, Gilliland DG, Druker B, Deininger MW
Blood. 2005 ; 106 (10) : 3377-3379.
PMID 16081687
 
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis.
Levine RL, Wadleigh M, Cools J, Ebert BL, Wernig G, Huntly BJ, Boggon TJ, Wlodarska I, Clark JJ, Moore S, Adelsperger J, Koo S, Lee JC, Gabriel S, Mercher T, D'Andrea A, Frˆhling S, Dˆhner K, Marynen P, Vandenberghe P, Mesa RA, Tefferi A, Griffin JD, Eck MJ, Sellers WR, Meyerson M, Golub TR, Lee SJ, Gilliland DG
Cancer cell. 2005 ; 7 (4) : 387-397.
PMID 15837627
 
JAK2 V617F Mutation is uncommon in chronic myelomonocytic leukaemia.
Johan MF, Goodeve AC, Bowen DT, Frew ME, Reilly JT
British journal of haematology. 2005 ; 130 (6) : page 968.
PMID 16156870
 
JAK the trigger.
Mahon FX
Oncogene. 2005 ; 24 (48) : 7125-7126.
PMID 16007127
 
PCM1-JAK2 fusion in myeloproliferative disorders and acute erythroid leukemia with t(8;9) translocation.
Murati A, Gelsi-Boyer V, Adˆ©laˆŲde J, Perot C, Talmant P, Giraudier S, Lodˆ© L, Letessier A, Delaval B, Brunel V, Imbert M, Garand R, Xerri L, Birnbaum D, Mozziconacci MJ, Chaffanet M
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2005 ; 19 (9) : 1692-1696.
PMID 16034466
 
Identification of an acquired mutation in Jak2 provides molecular insights into the pathogenesis of myeloproliferative disorders.
Pesu M, O'Shea J, Hennighausen L, Silvennoinen O
Molecular interventions. 2005 ; 5 (4) : 211-215.
PMID 16123535
 
The t(8;9)(p22;p24) is a recurrent abnormality in chronic and acute leukemia that fuses PCM1 to JAK2.
Reiter A, Walz C, Watmore A, Schoch C, Blau I, Schlegelberger B, Berger U, Telford N, Aruliah S, Yin JA, Vanstraelen D, Barker HF, Taylor PC, O'Driscoll A, Benedetti F, Rudolph C, Kolb HJ, Hochhaus A, Hehlmann R, Chase A, Cross NC
Cancer research. 2005 ; 65 (7) : 2662-2667.
PMID 15805263
 
JAKing up hematopoietic proliferation.
Shannon K, Van Etten RA
Cancer cell. 2005 ; 7 (4) : 291-293.
PMID 15837617
 
The JAK2 V617F activating tyrosine kinase mutation is an infrequent event in both atypical myeloproliferative disorders and myelodysplastic syndromes.
Steensma DP, Dewald GW, Lasho TL, Powell HL, McClure RF, Levine RL, Gilliland DG, Tefferi A
Blood. 2005 ; 106 (4) : 1207-1209.
PMID 15860661
 
The V617F mutation in Jak2 is not found in childhood acute lymphoblastic leukaemia.
Sulong S, Case M, Minto L, Wilkins B, Hall A, Irving J
British journal of haematology. 2005 ; 130 (6) : 964-965.
PMID 16156866
 
The JAK2V617F tyrosine kinase mutation in myeloproliferative disorders: status report and immediate implications for disease classification and diagnosis.
Tefferi A, Gilliland DG
Mayo Clinic proceedings. Mayo Clinic. 2005 ; 80 (7) : 947-958.
PMID 16007902
 
JAK2 in myeloproliferative disorders is not just another kinase.
Tefferi A, Gilliland DG
Cell cycle (Georgetown, Tex.). 2005 ; 4 (8) : 1053-1056.
PMID 15970705
 
JAK2 Val617Phe activating tyrosine kinase mutation in juvenile myelomonocytic leukemia.
Tono C, Xu G, Toki T, Takahashi Y, Sasaki S, Terui K, Ito E
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2005 ; 19 (10) : 1843-1844.
PMID 16079889
 
Identification of an acquired JAK2 mutation in polycythemia vera.
Zhao R, Xing S, Li Z, Fu X, Li Q, Krantz SB, Zhao ZJ
The Journal of biological chemistry. 2005 ; 280 (24) : 22788-22792.
PMID 15863514
 
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Contributor(s)

Written02-1998Jean-Loup Huret
Updated09-2005Sabine Strehl

Citation

This paper should be referenced as such :
Huret JL . JAK2 (janus kinase 2). Atlas Genet Cytogenet Oncol Haematol. February 1998 .
URL : http://AtlasGeneticsOncology.org/Genes/JAK98.html
Strehl S . JAK2 (janus kinase 2). Atlas Genet Cytogenet Oncol Haematol. September 2005 .
URL : http://AtlasGeneticsOncology.org/Genes/JAK98.html

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indexed on : Sat Jun 27 16:38:54 CEST 2009
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