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Description | The JUND protein contains 347 amino acids with a predicted molecular weight 35.2 kD. From N-terminus to C-terminus, JUND has a JNK phosphorylating motif (Ser90/Ser100), DNA binding domain, nuclear localization signal (NLS), and a leucine zipper domain. Since this protein lacks the JNK docking site, JUND can only be weakly phosphorylated by JNK. Although the JunD gene has no introns and produces a single transcript, the JUND mRNA translates two JUND protein isoforms, JUND-L and JUND-S. By using a different in-frame translational initiation site, the third AUG codon in JUND mRNA, the short version of JUND, JUND-S, was generated that lacks the N-terminal 43 amino acids. Due to this N-terminal truncation, the JUND-S is unable to associate with Menin, another tumor suppressor protein. |
Expression | JUND is the most broadly expressed member of the JUN family but expressed at low level. |
Localisation | The subcellular location of this protein is most likely in the nucleus. Less likely possibilities are in the cytoplasm and in the mitochondria. |
Function | JUND is a member of the JUN family of basic region leucine zipper (bZIP) DNA-binding proteins. Analysis of the protein expression levels demonstrated an opposite expression pattern between JUN and JUND. When cells entry into the G0 phase of the cell cycle by serum starvation, JUN level decreases and JUND level increases. Similar to JUNB, JUND has been shown as an antagonist of JUN in the induction of cyclin D1. Therefore, increasing the abundance of JUND may maintain the cells in a quiescent state. Transformation studies demonstrated that excess JUND protein could partially suppress the transformed phenotype mediated by JUN in cooperation with Ras. The effect of JUND in development appears to be marginal. Mice lacking JUND are viable with only mild defects in growth and spermatogenesis, whereas mice lacking JUN or JUNB die in embryo. |
c-jun is essential for normal mouse development and hepatogenesis. |
Hilberg F, Aguzzi A, Howells N, Wagner EF |
Nature. 1993 ; 365 (6442) : 179-181. |
PMID 8371760 |
|
Variations in Jun and Fos protein expression and AP-1 activity in cycling, resting and stimulated fibroblasts. |
Lallemand D, Spyrou G, Yaniv M, Pfarr CM |
Oncogene. 1997 ; 14 (7) : 819-830. |
PMID 9047389 |
|
The mammalian Jun proteins: redundancy and specificity. |
Mechta-Grigoriou F, Gerald D, Yaniv M |
Oncogene. 2001 ; 20 (19) : 2378-2389. |
PMID 11402334 |
|
Two proteins translated by alternative usage of initiation codons in mRNA encoding a JunD transcriptional regulator. |
Okazaki S, Ito T, Ui M, Watanabe T, Yoshimatsu K, Iba H |
Biochemical and biophysical research communications. 1998 ; 250 (2) : 347-353. |
PMID 9753632 |
|
Mouse JunD negatively regulates fibroblast growth and antagonizes transformation by ras. |
Pfarr CM, Mechta F, Spyrou G, Lallemand D, Carillo S, Yaniv M |
Cell. 1994 ; 76 (4) : 747-760. |
PMID 8124713 |
|
JunB is essential for mammalian placentation. |
Schorpp-Kistner M, Wang ZQ, Angel P, Wagner EF |
The EMBO journal. 1999 ; 18 (4) : 934-948. |
PMID 10022836 |
|
Translational regulation of the JunD messenger RNA. |
Short JD, Pfarr CM |
The Journal of biological chemistry. 2002 ; 277 (36) : 32697-32705. |
PMID 12105216 |
|
Targeted disruption of the murine junD gene results in multiple defects in male reproductive function. |
Thépot D, Weitzman JB, Barra J, Segretain D, Stinnakre MG, Babinet C, Yaniv M |
Development (Cambridge, England). 2000 ; 127 (1) : 143-153. |
PMID 10654608 |
|
Differential binding of the Menin tumor suppressor protein to JunD isoforms. |
Yazgan O, Pfarr CM |
Cancer research. 2001 ; 61 (3) : 916-920. |
PMID 11221882 |
|
| Nomenclature |
HGNC (Hugo) | JUND 6206 |
| Cards |
Atlas | JUNDID179 |
Entrez_Gene (NCBI) | JUND 3727 JunD proto-oncogene, AP-1 transcription factor subunit |
Aliases | AP-1 |
GeneCards (Weizmann) | JUND |
Ensembl hg19 (Hinxton) | ENSG00000130522 [Gene_View] |
Ensembl hg38 (Hinxton) | ENSG00000130522 [Gene_View]  ENSG00000130522 [Sequence] chr19:18279694-18281656 [Contig_View] JUND [Vega] |
ICGC DataPortal | ENSG00000130522 |
TCGA cBioPortal | JUND |
AceView (NCBI) | JUND |
Genatlas (Paris) | JUND |
WikiGenes | 3727 |
SOURCE (Princeton) | JUND |
Genetics Home Reference (NIH) | JUND |
| Genomic and cartography |
GoldenPath hg38 (UCSC) | JUND - chr19:18279694-18281656 - 19p13.11 [Description] (hg38-Dec_2013) |
GoldenPath hg19 (UCSC) | JUND - 19p13.11 [Description] (hg19-Feb_2009) |
GoldenPath | JUND - 19p13.11 [CytoView hg19] JUND - 19p13.11 [CytoView hg38] |
ImmunoBase | ENSG00000130522 |
Mapping of homologs : NCBI | JUND [Mapview hg19] JUND [Mapview hg38] |
OMIM | 165162 |
| Gene and transcription |
Genbank (Entrez) | AK223630 AW027337 BQ130444 CA502969 CB050506 |
RefSeq transcript (Entrez) | NM_001286968 NM_005354 |
RefSeq genomic (Entrez) | |
Consensus coding sequences : CCDS (NCBI) | JUND |
Cluster EST : Unigene | Hs.2780 [ NCBI ] |
CGAP (NCI) | Hs.2780 |
Alternative Splicing Gallery | ENSG00000130522 |
Gene Expression | JUND [ NCBI-GEO ] JUND [ EBI - ARRAY_EXPRESS ]
JUND [ SEEK ] JUND [ MEM ] |
Gene Expression Viewer (FireBrowse) | JUND [ Firebrowse - Broad ] |
SOURCE (Princeton) | Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60] |
Genevestigator | Expression in : [tissues]  [cell-lines]  [cancer]  [perturbations]   |
BioGPS (Tissue expression) | 3727 |
GTEX Portal (Tissue expression) | JUND |
Human Protein Atlas | ENSG00000130522-JUND [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
UniProt/SwissProt | P17535 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
NextProt | P17535 [Sequence] [Exons] [Medical] [Publications] |
With graphics : InterPro | P17535 |
Splice isoforms : SwissVar | P17535 |
PhosPhoSitePlus | P17535 |
Domaine pattern : Prosite (Expaxy) | BZIP (PS50217) BZIP_BASIC (PS00036) |
Domains : Interpro (EBI) | bZIP JNK JunD Leuzip_Jun TF_DNA-bd_sf |
Domain families : Pfam (Sanger) | bZIP_1 (PF00170) Jun (PF03957) |
Domain families : Pfam (NCBI) | pfam00170 pfam03957 |
Domain families : Smart (EMBL) | BRLZ (SM00338) |
Conserved Domain (NCBI) | JUND |
DMDM Disease mutations | 3727 |
Blocks (Seattle) | JUND |
PDB (RSDB) | 3U86 5VPA 5VPB 5VPC 5VPD 5VPE 5VPF |
PDB Europe | 3U86 5VPA 5VPB 5VPC 5VPD 5VPE 5VPF |
PDB (PDBSum) | 3U86 5VPA 5VPB 5VPC 5VPD 5VPE 5VPF |
PDB (IMB) | 3U86 5VPA 5VPB 5VPC 5VPD 5VPE 5VPF |
Structural Biology KnowledgeBase | 3U86 5VPA 5VPB 5VPC 5VPD 5VPE 5VPF |
SCOP (Structural Classification of Proteins) | 3U86 5VPA 5VPB 5VPC 5VPD 5VPE 5VPF |
CATH (Classification of proteins structures) | 3U86 5VPA 5VPB 5VPC 5VPD 5VPE 5VPF |
Superfamily | P17535 |
Human Protein Atlas [tissue] | ENSG00000130522-JUND [tissue] |
Peptide Atlas | P17535 |
HPRD | 01304 |
IPI | IPI00289547 |
| Protein Interaction databases |
DIP (DOE-UCLA) | P17535 |
IntAct (EBI) | P17535 |
FunCoup | ENSG00000130522 |
BioGRID | JUND |
STRING (EMBL) | JUND |
ZODIAC | JUND |
| Ontologies - Pathways |
QuickGO | P17535 |
Ontology : AmiGO | negative regulation of transcription by RNA polymerase II chromatin nuclear chromatin RNA polymerase II proximal promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific osteoblast development transcription coactivator activity protein binding nucleus nucleoplasm nucleoplasm transcription factor complex regulation of transcription by RNA polymerase II transcription by RNA polymerase II aging circadian rhythm transcription factor binding response to radiation response to light stimulus response to mechanical stimulus response to organic substance nuclear receptor binding enzyme binding response to lipopolysaccharide cellular response to hormone stimulus protein-DNA complex response to cytokine transcription factor AP-1 complex response to drug response to peptide hormone transcription regulatory region DNA binding positive regulation of cell differentiation positive regulation of osteoblast differentiation positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II response to cAMP regulation of cell cycle cellular response to calcium ion |
Ontology : EGO-EBI | negative regulation of transcription by RNA polymerase II chromatin nuclear chromatin RNA polymerase II proximal promoter sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific osteoblast development transcription coactivator activity protein binding nucleus nucleoplasm nucleoplasm transcription factor complex regulation of transcription by RNA polymerase II transcription by RNA polymerase II aging circadian rhythm transcription factor binding response to radiation response to light stimulus response to mechanical stimulus response to organic substance nuclear receptor binding enzyme binding response to lipopolysaccharide cellular response to hormone stimulus protein-DNA complex response to cytokine transcription factor AP-1 complex response to drug response to peptide hormone transcription regulatory region DNA binding positive regulation of cell differentiation positive regulation of osteoblast differentiation positive regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II response to cAMP regulation of cell cycle cellular response to calcium ion |
Pathways : KEGG | MAPK signaling pathway Osteoclast differentiation |
REACTOME | P17535 [protein] |
REACTOME Pathways | R-HSA-9018519 [pathway] |
NDEx Network | JUND |
Atlas of Cancer Signalling Network | JUND |
Wikipedia pathways | JUND |
| Orthology - Evolution |
OrthoDB | 3727 |
GeneTree (enSembl) | ENSG00000130522 |
Phylogenetic Trees/Animal Genes : TreeFam | JUND |
HOGENOM | P17535 |
Homologs : HomoloGene | JUND |
Homology/Alignments : Family Browser (UCSC) | JUND |
| Gene fusions - Rearrangements |
Fusion Cancer (Beijing) | JUND [19p13.11] - S100B [21q22.3] [FUSC003836] |
Fusion : FusionGDB | 18093 18094 18095 18096 |
Fusion : Fusion_Hub | JUND--CCDC13 JUND--CNOT8 JUND--KIAA1683 JUND--LOC100499227 JUND--NASP JUND--NPAS1 JUND--PHF5A JUND--S100B JUND--SERPINE1 JUND--SFTPA1 JUND--SFTPC JUND--SNRNP70 |
Fusion : Quiver | JUND |
| Polymorphisms : SNP and Copy number variants |
NCBI Variation Viewer | JUND [hg38] |
dbSNP Single Nucleotide Polymorphism (NCBI) | JUND |
dbVar | JUND |
ClinVar | JUND |
1000_Genomes | JUND |
Exome Variant Server | JUND |
ExAC (Exome Aggregation Consortium) | ENSG00000130522 |
GNOMAD Browser | ENSG00000130522 |
Varsome Browser | JUND |
Genetic variants : HAPMAP | 3727 |
Genomic Variants (DGV) | JUND [DGVbeta] |
DECIPHER | JUND [patients] [syndromes] [variants] [genes] |
CONAN: Copy Number Analysis | JUND |
| Mutations |
ICGC Data Portal | JUND |
TCGA Data Portal | JUND |
Broad Tumor Portal | JUND |
OASIS Portal | JUND [ Somatic mutations - Copy number] |
Somatic Mutations in Cancer : COSMIC | JUND [overview] [genome browser] [tissue] [distribution] |
Somatic Mutations in Cancer : COSMIC3D | JUND |
Mutations and Diseases : HGMD | JUND |
LOVD (Leiden Open Variation Database) | Whole genome datasets |
LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
BioMuta | search JUND |
DgiDB (Drug Gene Interaction Database) | JUND |
DoCM (Curated mutations) | JUND (select the gene name) |
CIViC (Clinical Interpretations of Variants in Cancer) | JUND (select a term) |
intoGen | JUND |
NCG5 (London) | JUND |
Cancer3D | JUND(select the gene name) |
Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
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OMIM | 165162 |
Orphanet | |
DisGeNET | JUND |
Medgen | JUND |
Genetic Testing Registry | JUND
|
NextProt | P17535 [Medical] |
TSGene | 3727 |
GENETests | JUND |
Target Validation | JUND |
Huge Navigator |
JUND [HugePedia] |
snp3D : Map Gene to Disease | 3727 |
BioCentury BCIQ | JUND |
ClinGen | JUND |
| Clinical trials, drugs, therapy |
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Chemical/Protein Interactions : CTD | 3727 |
Chemical/Pharm GKB Gene | PA30008 |
Clinical trial | JUND |
| Miscellaneous |
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canSAR (ICR) | JUND (select the gene name) |
DataMed Index | JUND |
| Probes |
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| Litterature |
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PubMed | 120 Pubmed reference(s) in Entrez |
GeneRIFs | Gene References Into Functions (Entrez) |
CoreMine | JUND |
EVEX | JUND |
GoPubMed | JUND |
iHOP | JUND |