JUND (jun D proto-oncogene)

2003-01-01   Fei Chen 

Health Effects Laboratory Division, NIOSH, 1095 Willowdale Rd, Morgantown, WV 26505, USA

Identity

HGNC
LOCATION
19p13.11
LOCUSID
ALIAS
AP-1
FUSION GENES

DNA/RNA

Description

The gene for JUND is located on the region of chromosome 19p13.1-p12 covering 1409bp. Similar to other members of JUN family, the JunD gene is also intronless.

Proteins

Atlas Image

Description

The JUND protein contains 347 amino acids with a predicted molecular weight 35.2 kD. From N-terminus to C-terminus, JUND has a JNK phosphorylating motif (Ser90/Ser100), DNA binding domain, nuclear localization signal (NLS), and a leucine zipper domain. Since this protein lacks the JNK docking site, JUND can only be weakly phosphorylated by JNK. Although the JunD gene has no introns and produces a single transcript, the JUND mRNA translates two JUND protein isoforms, JUND-L and JUND-S. By using a different in-frame translational initiation site, the third AUG codon in JUND mRNA, the short version of JUND, JUND-S, was generated that lacks the N-terminal 43 amino acids. Due to this N-terminal truncation, the JUND-S is unable to associate with Menin, another tumor suppressor protein.

Expression

JUND is the most broadly expressed member of the JUN family but expressed at low level.

Localisation

The subcellular location of this protein is most likely in the nucleus. Less likely possibilities are in the cytoplasm and in the mitochondria.

Function

JUND is a member of the JUN family of basic region leucine zipper (bZIP) DNA-binding proteins. Analysis of the protein expression levels demonstrated an opposite expression pattern between JUN and JUND. When cells entry into the G0 phase of the cell cycle by serum starvation, JUN level decreases and JUND level increases. Similar to JUNB, JUND has been shown as an antagonist of JUN in the induction of cyclin D1. Therefore, increasing the abundance of JUND may maintain the cells in a quiescent state. Transformation studies demonstrated that excess JUND protein could partially suppress the transformed phenotype mediated by JUN in cooperation with Ras. The effect of JUND in development appears to be marginal. Mice lacking JUND are viable with only mild defects in growth and spermatogenesis, whereas mice lacking JUN or JUNB die in embryo.

Implicated in

Bibliography

Pubmed IDLast YearTitleAuthors
83717601993c-jun is essential for normal mouse development and hepatogenesis.Hilberg F et al
90473891997Variations in Jun and Fos protein expression and AP-1 activity in cycling, resting and stimulated fibroblasts.Lallemand D et al
114023342001The mammalian Jun proteins: redundancy and specificity.Mechta-Grigoriou F et al
97536321998Two proteins translated by alternative usage of initiation codons in mRNA encoding a JunD transcriptional regulator.Okazaki S et al
81247131994Mouse JunD negatively regulates fibroblast growth and antagonizes transformation by ras.Pfarr CM et al
100228361999JunB is essential for mammalian placentation.Schorpp-Kistner M et al
121052162002Translational regulation of the JunD messenger RNA.Short JD et al
106546082000Targeted disruption of the murine junD gene results in multiple defects in male reproductive function.Thépot D et al
112218822001Differential binding of the Menin tumor suppressor protein to JunD isoforms.Yazgan O et al

Other Information

Locus ID:

NCBI: 3727
MIM: 165162
HGNC: 6206
Ensembl: ENSG00000130522

Variants:

dbSNP: 3727
ClinVar: 3727
TCGA: ENSG00000130522
COSMIC: JUND

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130522ENST00000252818P17535
ENSG00000130522ENST00000600972U3KPR5

Expression (GTEx)

0
100
200
300
400
500
600
700
800

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
MAPK signaling pathwayKEGGhsa04010
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
IL-17 signaling pathwayKEGGko04657
IL-17 signaling pathwayKEGGhsa04657

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA283MAPK8GenePathwayassociated23922006
PA30621MAPK14GenePathwayassociated23922006

References

Pubmed IDYearTitleCitations
223272962012The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.102
150440192004HBZ interacts with JunD and stimulates its transcriptional activity.64
127278412003Constitutive activation of nuclear factor kappaB p50/p65 and Fra-1 and JunD is essential for deregulated interleukin 6 expression in prostate cancer.62
180785172007HTLV-1 HBZ cooperates with JunD to enhance transcription of the human telomerase reverse transcriptase gene (hTERT).59
145597912003Menin, a tumor suppressor, represses JunD-mediated transcriptional activity by association with an mSin3A-histone deacetylase complex.55
160071202005JunD activates transcription of the human ferritin H gene through an antioxidant response element during oxidative stress.54
184435932008Jund is a determinant of macrophage activation and is associated with glomerulonephritis susceptibility.41
246586852014A time- and matrix-dependent TGFBR3-JUND-KRT5 regulatory circuit in single breast epithelial cells and basal-like premalignancies.37
183219532008Gene expression profiling in human skeletal muscle during recovery from eccentric exercise.35
185626902008JunD represses transcription and translation of the tight junction protein zona occludens-1 modulating intestinal epithelial barrier function.35

Citation

Fei Chen

JUND (jun D proto-oncogene)

Atlas Genet Cytogenet Oncol Haematol. 2003-01-01

Online version: http://atlasgeneticsoncology.org/gene/179/jund