| Written | 2006-11 | Takeshi Setogawa, Testu Akiyama |
| Laboratory of Molecular and Genetic Information, Institute for Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan |
| Identity |
| Alias_symbol (synonym) | NLI |
| CLIM2 | |
| Other alias | |
| HGNC (Hugo) | LDB1 |
| LocusID (NCBI) | 8861 |
| Atlas_Id | 41135 |
| Location | 10q24.32 [Link to chromosome band 10q24] |
| Location_base_pair | Starts at 102107566 and ends at 102114966 bp from pter ( according to hg19-Feb_2009) [Mapping LDB1.png] |
| Fusion genes (updated 2017) | Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands) |
| LDB1 (10q24.32) / LDB1 (10q24.32) | PRICKLE4 (6p21.1) / LDB1 (10q24.32) |
| DNA/RNA |
| Description | 7kb; 11exons |
| Transcription | 2292 nucleotides mRNA |
| Protein |
| Description | 375 amino acids; 42.8 kDa protein |
| Expression | Widely expressed |
| Localisation | Nuclear |
| Function | LDB1 is a nuclear protein that contains an N-terminal dimerization domain and a C-terminal LIM interaction domain (LID). LDB1 binds to LIM-homeodomain (LIM-HD) and LIM-only (LMO) proteins. It acts as an adaptor protein that mediates interactions between different classes of transcription factors and their cofactors. LDB1 forms a complex with LKB1, LMO4, and GATA-6. The tumor suppressor LKB1is mutated in Peutz Jeghers syndrome and various sporadic cancers. A complex containing LDB1, LKB1, LMO4, and GATA-6 induces cyclin-dependent kinase inhibitor p21 expression. Targeted deletion of the Ldb1 gene in mice displays multiple developmental defects that reveal a requirement of Ldb1 gene during normal development. |
| Implicated in |
| Note | |
| Entity | Oral squamous cell carcinoma |
| Oncogenesis | LDB1 and LMO4 are frequently detected in less-differentiated and metastasized squamous carcinoma, and overexpressed at the carcinoma invasive front. |
| Bibliography |
| Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins. |
| Agulnick AD, Taira M, Breen JJ, Tanaka T, Dawid IB, Westphal H |
| Nature. 1996 ; 384 (6606) : 270-272. |
| PMID 8918878 |
| A family of LIM domain-associated cofactors confer transcriptional synergism between LIM and Otx homeodomain proteins. |
| Bach I, Carrière C, Ostendorff HP, Andersen B, Rosenfeld MG |
| Genes & development. 1997 ; 11 (11) : 1370-1380. |
| PMID 9192866 |
| Ssdp proteins interact with the LIM-domain-binding protein Ldb1 to regulate development. |
| Chen L, Segal D, Hukriede NA, Podtelejnikov AV, Bayarsaihan D, Kennison JA, Ogryzko VV, Dawid IB, Westphal H |
| Proceedings of the National Academy of Sciences of the United States of America. 2002 ; 99 (22) : 14320-14325. |
| PMID 12381786 |
| Functional analysis of the nuclear LIM domain interactor NLI. |
| Jurata LW, Gill GN |
| Molecular and cellular biology. 1997 ; 17 (10) : 5688-5698. |
| PMID 9315627 |
| LIM-domain-binding protein 1: a multifunctional cofactor that interacts with diverse proteins. |
| Matthews JM, Visvader JE |
| EMBO reports. 2003 ; 4 (12) : 1132-1137. |
| PMID 14647207 |
| The LIM-only protein, LMO4, and the LIM domain-binding protein, LDB1, expression in squamous cell carcinomas of the oral cavity. |
| Mizunuma H, Miyazawa J, Sanada K, Imai K |
| British journal of cancer. 2003 ; 88 (10) : 1543-1548. |
| PMID 12771919 |
| Functional ablation of the mouse Ldb1 gene results in severe patterning defects during gastrulation. |
| Mukhopadhyay M, Teufel A, Yamashita T, Agulnick AD, Chen L, Downs KM, Schindler A, Grinberg A, Huang SP, Dorward D, Westphal H |
| Development (Cambridge, England). 2003 ; 130 (3) : 495-505. |
| PMID 12490556 |
| The tumor suppressor LKB1 induces p21 expression in collaboration with LMO4, GATA-6, and Ldb1. |
| Setogawa T, Shinozaki-Yabana S, Masuda T, Matsuura K, Akiyama T |
| Biochemical and biophysical research communications. 2006 ; 343 (4) : 1186-1190. |
| PMID 16580634 |
| The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation. |
| Visvader JE, Mao X, Fujiwara Y, Hahm K, Orkin SH |
| Proceedings of the National Academy of Sciences of the United States of America. 1997 ; 94 (25) : 13707-13712. |
| PMID 9391090 |
| Citation |
| This paper should be referenced as such : |
| Akiyama, T ; Setogawa, T |
| LDB1 (LIM domain binding 1) |
| Atlas Genet Cytogenet Oncol Haematol. 2007;11(3):167-168. |
| Free journal version : [ pdf ] [ DOI ] |
| On line version : http://AtlasGeneticsOncology.org/Genes/LDB1ID41135ch10q24.html |
| External links |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Wed Nov 13 21:33:33 CET 2019 |
For comments and suggestions or contributions, please contact us