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LPP (lipoma preferred partner)

Written2004-05Marleen M Petit
Laboratory for Molecular Oncology, Department of Human Genetics, University of Leuven (K.U.Leuven) & VIB, Herestraat 49, B-3000 Leuven, Belgium

(Note : for Links provided by Atlas : click)

Identity

Alias_namesLIM domain-containing preferred translocation partner in lipoma
Other alias
HGNC (Hugo) LPP
LocusID (NCBI) 4026
Atlas_Id 72
Location 3q28  [Link to chromosome band 3q28]
Location_base_pair Starts at 188212933 and ends at 188890671 bp from pter ( according to hg19-Feb_2009)  [Mapping LPP.png]
 
  Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DLG1 (3q29) / LPP (3q28)DMD (Xp21.2) / LPP (3q28)FAM19A3 (1p13.2) / LPP (3q28)
HMGA2 (12q14.3) / LPP (3q28)KMT2A (11q23.3) / LPP (3q28)LPP (3q28) / ABHD17C (15q25.1)
LPP (3q28) / ADGRL3 (4q13.1)LPP (3q28) / BCL6 (3q27.3)LPP (3q28) / CASR (3q13.33)
LPP (3q28) / CASR (3q21.1)LPP (3q28) / CD58 (1p13.1)LPP (3q28) / CHSY1 (15q26.3)
LPP (3q28) / CLSTN2 (3q23)LPP (3q28) / F2 (11p11.2)LPP (3q28) / GNL2 (1p34.3)
LPP (3q28) / GOLIM4 (3q26.2)LPP (3q28) / HMGA2 (12q14.3)LPP (3q28) / KMT2A (11q23.3)
LPP (3q28) / LPP (3q28)LPP (3q28) / LSM1 (8p11.23)LPP (3q28) / P3H2 (3q28)
LPP (3q28) / SPATA16 (3q26.31)LPP (3q28) / SSU72 (1p36.33)LPP (3q28) / ST6GAL1 (3q27.3)
LPP (3q28) / TP63 (3q28)LPP (3q28) / UBE2R2 (9p13.3)NCKIPSD (3p21.31) / LPP (3q28)
SEPT9 (17q25.2) / LPP (3q28)SEPT9 (17q25.3) / LPP (3q28)SFTPB (2p11.2) / LPP (3q28)
TAGLN2 (1q23.2) / LPP (3q28)TC2N (14q32.12) / LPP (3q28)

DNA/RNA

 
Description At least 11 exons; predicted start codon in exon 3, stop codon in exon 11; the protein coding region is covered by the overlapping "CEPH Mark 1" YAC clones 135H6 and 192B10 (start codon in 135H6, stop codon in 192B10) and is dispersed over at least 400 kb genomic DNA; the LIM domains are encoded by separate exons: LIM 1 is encoded by exon 8, LIM 2 by exon 9, and LIM 3 by exon 10 and part of exon 11.
Transcription mRNA: ubiquitously: > 10 kb; testis: additional transcripts of 1.8 kb and 1.25 kb
Pseudogene no pseudogenes

Protein

Description 612 amino acids; proline-rich region (amino-terminal 2/3 of the protein) followed by three LIM domains (carboxy-terminal 1/3 of the protein). Proline-rich region contains an alfa-actinin binding site, two VASP-binding motifs, and a nuclear export signal.
Expression Smooth muscle marker; readily detected on Western blot with an LPP-antibody in all fibroblastic and epithelial cell lines tested to date.
Localisation LPP is present in the cytoplasm of cells as well as at sites of cell adhesion such as focal adhesions (attachments sites to the extracellular matrix) and cell-cell contacts; LPP also shuttles to the nucleus and its nuclear-cytoplasmic localisation is regulated in part by a nuclear export signal (NES) which is sensitive to the drug leptomycin B.
Function Because of their structural features (many protein-protein interaction domains) and their characteristic to shuttle between the nucleus and the cytoplasm, LPP and its family members (see below) have been proposed to be scaffolding proteins involved in signal transduction from sites of cell adhesion to the nucleus; LPP has been shown to harbour transcriptional activation capacity in luciferase reporter assays, suggesting that LPP may be directly involved in the regulation of gene expression; LPP was found to be highly expressed in smooth muscle, and a role for LPP in regulating cell motility was proposed; the precise function of LPP remains to be elucidated.
Homology LPP is a member of the zyxin family of proteins, which contains five members: ajuba, LIMD1, LPP, TRIP6 and zyxin. The family hallmark of these proteins are three clustered LIM domains at the carboxy-terminus, which are protein interaction domains. All family members are present at sites of cell adhesion and have the ability to shuttle to the nucleus, and all family members have one or more nuclear export signals.

Mutations

Somatic HMGA2/LPP fusion proteins and MLL/LPP fusion proteins (Fig2).

Implicated in

Note
  
Entity solitary lipomas
Disease Benign tumors of adipose tissue.
Prognosis Can be surgically removed with no recurrence in most cases.
Cytogenetics More than 60% of solitary lipomas have an aberrant karyotype; 2/3 of these carry 12q15 rearrangements, most often translocations, affecting the HMGA2 gene; 1/4 of the latter have chromosomal region 3q27-q28 (containing LPP) as 12q15 translocation partner as such creating an HMGA2/LPP fusion gene.
Hybrid/Mutated Gene HMGA2/LPP hybrid gene containing the first three exons of HMGA2 and exons 8-11 or 9-11 of LPP; under the regulation of the HMGA2 promoter.
Abnormal Protein HMGA2/LPP fusion transcripts encode the three DNA-binding domains of HMGA2 followed by two LIM domains (LIM 2 and LIM 3) or a portion of the proline-rich region and all three LIM domains of LPP.
 
  
  
Entity Pulmonary chondroid hamartomas
Disease Benign mesenchymal tumors of the lung.
Prognosis good
Cytogenetics More than 70% of pulmonary chondroid hamartomas have an aberrant karyotype; 70% of these carry 12q15 rearrangements, most often translocations, affecting the HMGA2 gene; 1/8 of the latter have chromosomal region 3q27-q28 (containing LPP) as 12q15 translocation partner as such creating an HMGA2/LPP fusion gene.
Hybrid/Mutated Gene HMGA2/LPP hybrid gene containing the first three exons of HMGA2 and exons 9-11 of LPP; under the regulation of the HMGA2 promoter.
Abnormal Protein HMGA2/LPP fusion transcripts encode the three DNA-binding domains of HMGA2 followed by the two most carboxy-terminal LIM domains (LIM 2 and LIM 3) of LPP.
  
  
Entity Parosteal lipoma
Disease Rare deep-seated benign tumor of adipose tissue comprising less than 0.5% of all lipomas; parosteal lipomas exhibit a contiguous relationship with the periostium; because of their intimate relationship to the bone, they are considered as lipomas of bone.
Prognosis Most often asymptomatic; in some cases: loss of motor and/or sensory function as a result of the compression or stretching of a nerve.
Cytogenetics One case reported with rearrangement of LPP t(3;12)(q28;q14).
Hybrid/Mutated Gene HMGA2/LPP hybrid gene containing the first three exons of HMGA2 and exons 9-11 of LPP; under the regulation of the HMGA2 promoter.
Abnormal Protein HMGA2/LPP fusion transcripts encode the three DNA-binding domains of HMGA2 followed by the two most carboxy-terminal LIM domains (LIM 2 and LIM 3) of LPP.
  
  
Entity Soft tissue chondroma
Disease Benign tumor of cartilage; rare entity.
Cytogenetics Only 31 cases with abnormal karyotypes have been reported (11-2003); 12q15 nonrandomly involved; one case reported with rearrangement of LPP t(3;12)(q27;q15).
Hybrid/Mutated Gene HMGA2/LPP hybrid gene containing the first three exons of HMGA2 and exons 9-11 of LPP; under the regulation of the HMGA2 promoter.
Abnormal Protein HMGA2/LPP fusion transcripts encode the three DNA-binding domains of HMGA2 followed by the two most carboxy-terminal LIM domains (LIM 2 and LIM 3) of LPP.
  
  
Entity AML-M5
Disease Secondary leukemia following treatment with DNA topoisomerase II inhibitors.
Cytogenetics MLL gene on 11q23 frequently involved; one case reported with rearrangement of LPP t(3;11)(q28;q23).
Hybrid/Mutated Gene MLL/LPP hybrid gene containing the first 8 exons of MLL and exons 9-11 of LPP; under the regulation of the MLL promoter.
Abnormal Protein MLL/LPP fusion transcripts encode the three DNA-binding domains and the methyltransferase-like domain of MLL followed by the two most carboxy-terminal LIM domains (LIM 2 and LIM 3) of LPP.
  

Breakpoints

 

Bibliography

Human LPP gene is fused to MLL in a secondary acute leukemia with a t(3;11) (q28;q23).
Dahéron L, Veinstein A, Brizard F, Drabkin H, Lacotte L, Guilhot F, Larsen CJ, Brizard A, Roche J
Genes, chromosomes & cancer. 2001 ; 31 (4) : 382-389.
PMID 11433529
 
Fusion, disruption, and expression of HMGA2 in bone and soft tissue chondromas.
Dahlén A, Mertens F, Rydholm A, Brosjö O, Wejde J, Mandahl N, Panagopoulos I
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2003 ; 16 (11) : 1132-1140.
PMID 14614053
 
LPP, a LIM protein highly expressed in smooth muscle.
Gorenne I, Nakamoto RK, Phelps CP, Beckerle MC, Somlyo AV, Somlyo AP
American journal of physiology. Cell physiology. 2003 ; 285 (3) : C674-C685.
PMID 12760907
 
A novel LPP fusion gene indicates the crucial role of truncated LPP proteins in lipomas and pulmonary chondroid hamartomas.
Lemke I, Rogalla P, Bullerdiek J
Cytogenetics and cell genetics. 2001 ; 95 (3-4) : 153-156.
PMID 12063392
 
The lipoma preferred partner LPP interacts with alpha-actinin.
Li B, Zhuang L, Reinhard M, Trueb B
Journal of cell science. 2003 ; 116 (Pt 7) : 1359-1366.
PMID 12615977
 
Prediction of cell type-specific gene modules: identification and initial characterization of a core set of smooth muscle-specific genes.
Nelander S, Mostad P, Lindahl P
Genome research. 2003 ; 13 (8) : 1838-1854.
PMID 12869577
 
LPP, an actin cytoskeleton protein related to zyxin, harbors a nuclear export signal and transcriptional activation capacity.
Petit MM, Fradelizi J, Golsteyn RM, Ayoubi TA, Menichi B, Louvard D, Van de Ven WJ, Friederich E
Molecular biology of the cell. 2000 ; 11 (1) : 117-129.
PMID 10637295
 
The focal adhesion and nuclear targeting capacity of the LIM-containing lipoma-preferred partner (LPP) protein.
Petit MM, Meulemans SM, Van de Ven WJ
The Journal of biological chemistry. 2003 ; 278 (4) : 2157-2168.
PMID 12441356
 
LPP, the preferred fusion partner gene of HMGIC in lipomas, is a novel member of the LIM protein gene family.
Petit MM, Mols R, Schoenmakers EF, Mandahl N, Van de Ven WJ
Genomics. 1996 ; 36 (1) : 118-129.
PMID 8812423
 
Expression of reciprocal fusion transcripts of the HMGIC and LPP genes in parosteal lipoma.
Petit MM, Swarts S, Bridge JA, Van de Ven WJ
Cancer genetics and cytogenetics. 1998 ; 106 (1) : 18-23.
PMID 9772904
 
The t(3;12)(q27;q14-q15) with underlying HMGIC-LPP fusion is not determining an adipocytic phenotype.
Rogalla P, Kazmierczak B, Meyer-Bolte K, Tran KH, Bullerdiek J
Genes, chromosomes & cancer. 1998 ; 22 (2) : 100-104.
PMID 9598796
 

Citation

This paper should be referenced as such :
Petit, MM
LPP (lipoma preferred partner)
Atlas Genet Cytogenet Oncol Haematol. 2004;8(3):193-197.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/LPPID72.html


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(3;11)(q28;q23) KMT2A/LPP
del(3)(q27):del(3)(q27q28) LPP/BCL6
del(3)(q27q28) LPP/BCL6


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 14 ]
  Bone: Soft tissue chondroma with t(3;12)(q27;q15) HMGA2/LPP
Soft Tissues: Lipoma / benign lipomatous tumors
Soft tissue tumors: an overview
Lung: Translocations in Squamous Cell Carcinoma
del(3)(q28q28) LPP/TPRG1
t(1;3)(p13;q28) FAM19A3/LPP
t(3;3)(q26;q28) LPP/GOLIM4
t(3;3)(q26;q28) LPP/SPATA16
t(3;3)(q27;q28) LPP/ST6GAL1
t(3;11)(q28;p11) LPP/F2
t(3;12)(q28;q14) HMGA2/LPP
t(3;14)(q28;q32) TC2N/LPP
t(3;15)(q28;q25) LPP/ABHD17C
t(3;17)(q28;q25) SEPT9/LPP


External links

Nomenclature
HGNC (Hugo)LPP   6679
Cards
AtlasLPPID72
Entrez_Gene (NCBI)LPP  4026  LIM domain containing preferred translocation partner in lipoma
Aliases
GeneCards (Weizmann)LPP
Ensembl hg19 (Hinxton)ENSG00000145012 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000145012 [Gene_View]  ENSG00000145012 [Sequence]  chr3:188212933-188890671 [Contig_View]  LPP [Vega]
ICGC DataPortalENSG00000145012
TCGA cBioPortalLPP
AceView (NCBI)LPP
Genatlas (Paris)LPP
WikiGenes4026
SOURCE (Princeton)LPP
Genetics Home Reference (NIH)LPP
Genomic and cartography
GoldenPath hg38 (UCSC)LPP  -     chr3:188212933-188890671 +  3q27.3-q28   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LPP  -     3q27.3-q28   [Description]    (hg19-Feb_2009)
GoldenPathLPP - 3q27.3-q28 [CytoView hg19]  LPP - 3q27.3-q28 [CytoView hg38]
ImmunoBaseENSG00000145012
Mapping of homologs : NCBILPP [Mapview hg19]  LPP [Mapview hg38]
OMIM600700   601626   
Gene and transcription
Genbank (Entrez)AA813328 AI126032 AK055214 AK123506 AK302959
RefSeq transcript (Entrez)NM_001167671 NM_001167672 NM_005578
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LPP
Cluster EST : UnigeneHs.720220 [ NCBI ]
CGAP (NCI)Hs.720220
Alternative Splicing GalleryENSG00000145012
Gene ExpressionLPP [ NCBI-GEO ]   LPP [ EBI - ARRAY_EXPRESS ]   LPP [ SEEK ]   LPP [ MEM ]
Gene Expression Viewer (FireBrowse)LPP [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4026
GTEX Portal (Tissue expression)LPP
Human Protein AtlasENSG00000145012-LPP [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ93052   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ93052  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ93052
Splice isoforms : SwissVarQ93052
PhosPhoSitePlusQ93052
Domaine pattern : Prosite (Expaxy)LIM_DOMAIN_1 (PS00478)    LIM_DOMAIN_2 (PS50023)   
Domains : Interpro (EBI)LPP    Znf_LIM   
Domain families : Pfam (Sanger)LIM (PF00412)   
Domain families : Pfam (NCBI)pfam00412   
Domain families : Smart (EMBL)LIM (SM00132)  
Conserved Domain (NCBI)LPP
DMDM Disease mutations4026
Blocks (Seattle)LPP
SuperfamilyQ93052
Human Protein Atlas [tissue]ENSG00000145012-LPP [tissue]
Peptide AtlasQ93052
HPRD02828
IPIIPI00023704   IPI00793907   IPI00884332   IPI00797120   IPI00924594   IPI00927909   IPI00927693   IPI00927466   IPI00927168   IPI00794013   IPI00926750   IPI00926532   
Protein Interaction databases
DIP (DOE-UCLA)Q93052
IntAct (EBI)Q93052
FunCoupENSG00000145012
BioGRIDLPP
STRING (EMBL)LPP
ZODIACLPP
Ontologies - Pathways
QuickGOQ93052
Ontology : AmiGOstress fiber  protein binding  nucleus  cytosol  plasma membrane  focal adhesion  focal adhesion  focal adhesion  biological_process  metal ion binding  cell-cell adhesion  
Ontology : EGO-EBIstress fiber  protein binding  nucleus  cytosol  plasma membrane  focal adhesion  focal adhesion  focal adhesion  biological_process  metal ion binding  cell-cell adhesion  
NDEx NetworkLPP
Atlas of Cancer Signalling NetworkLPP
Wikipedia pathwaysLPP
Orthology - Evolution
OrthoDB4026
GeneTree (enSembl)ENSG00000145012
Phylogenetic Trees/Animal Genes : TreeFamLPP
HOGENOMQ93052
Homologs : HomoloGeneLPP
Homology/Alignments : Family Browser (UCSC)LPP
Gene fusions - Rearrangements
Fusion : MitelmanFAM19A3/LPP [1p13.2/3q28]  [t(1;3)(p13;q28)]  
Fusion : MitelmanHMGA2/LPP [12q14.3/3q28]  [t(2;12)(q37;q14)]  [t(3;12)(q28;q14)]  
Fusion : MitelmanLPP/ABHD17C [3q28/15q25.1]  [t(3;15)(q28;q25)]  
Fusion : MitelmanLPP/BCL6 [3q28/3q27.3]  [del(3)(q27)]  [del(3)(q27q28)]  
Fusion : MitelmanLPP/CASR [3q28/3q21.1]  [t(3;3)(q21;q28)]  
Fusion : MitelmanLPP/F2 [3q28/11p11.2]  [t(3;11)(q28;p11)]  
Fusion : MitelmanLPP/GOLIM4 [3q28/3q26.2]  [t(3;3)(q26;q28)]  
Fusion : MitelmanLPP/SPATA16 [3q28/3q26.31]  [t(3;3)(q26;q28)]  
Fusion : MitelmanLPP/ST6GAL1 [3q28/3q27.3]  [t(3;3)(q27;q28)]  
Fusion : MitelmanSEPT9/LPP [17q25.2/3q28]  [t(3;17)(q28;q25)]  
Fusion : MitelmanTC2N/LPP [14q32.12/3q28]  [t(3;14)(q28;q32)]  
Fusion : COSMICLPP [3q28]  -  KMT2A [11q23.3]  [fusion_1820]  [fusion_1821]  
Fusion PortalLPP 3q28 CASR 3q21.1 OV
Fusion PortalLPP 3q28 CLSTN2 3q23 HNSC
Fusion PortalLPP 3q28 F2 11p11.2 OV
Fusion PortalLPP 3q28 FAM108C1 BRCA
Fusion PortalLPP 3q28 GOLIM4 3q26.2 LUSC
Fusion PortalLPP 3q28 LEPREL1 HNSC
Fusion PortalLPP 3q28 SPATA16 3q26.31 BRCA
Fusion PortalLPP 3q28 ST6GAL1 3q27.3 LUSC
Fusion PortalLPP 3q28 TP63 3q28 BRCA
Fusion PortalSEPT9 17q25.2 LPP 3q28 BRCA
Fusion PortalTC2N 14q32.12 LPP 3q28 LUSC
Fusion : TICdbHMGA2 [12q14.3]  -  LPP [3q28]
Fusion : TICdbKMT2A [11q23.3]  -  LPP [3q28]
Fusion Cancer (Beijing)SFTPB [2p11.2]  -  LPP [3q28]  [FUSC002777]
Fusion : FusionGDB10080    10147    17238    18675    20022    20023    20024    20025    20026    20027    20028    20029    20030    20031    20032   
20033    20034    20035    20036    20037    20038    20039    20040    20041    20042    20043    20044    20045    20046    20047   
20048    20049    20050    23617    25832    31894    36253    37138    37520    39258   
Fusion : Fusion_HubABTB2--LPP    ADD3--LPP    AF1Q--LPP    BCL6--LPP    BNC2--LPP    CASR--LPP    CDK12--LPP    COL1A2--LPP    DGKG--LPP    DIP2A--LPP    DLG1--LPP    DMD--LPP    FBXL2--LPP    FNDC3B--LPP    GLRX3--LPP   
HMGA2--LPP    HMGIC--LPP    KCMF1--LPP    KIAA0922--LPP    KIAA1217--LPP    KMT2A--LPP    LARS2--LPP    LPP--ADIPOQ    LPP--AFTPH    LPP--ANTXR2    LPP--AP002884.3    LPP--ARHGAP10    LPP--ATP5C1    LPP--ATRAID    LPP--BCL6   
LPP--BIRC2    LPP--C10ORF107    LPP--C12ORF9    LPP--CALM2    LPP--CASR    LPP--CAST    LPP--CBLB    LPP--CCDC50    LPP--CCDC53    LPP--CD58    LPP--CEP63    LPP--CHSY1    LPP--CLDN1    LPP--CLDN11    LPP--CLMN   
LPP--CLPTM1L    LPP--CLSTN2    LPP--CLTA    LPP--CMC1    LPP--COG5    LPP--COL4A2    LPP--COPS8    LPP--CTNNA1    LPP--DCAF16    LPP--DSTN    LPP--F2    LPP--FAM108C1    LPP--FOXP1    LPP--GALNTL4    LPP--GNB4   
LPP--GNL2    LPP--GOLGA3    LPP--GOLIM4    LPP--HACE1    LPP--HADHB    LPP--HECTD1    LPP--HMGA2    LPP--HMGIC    LPP--HRASLS    LPP--IFT80    LPP--IGF2BP2    LPP--IGFBP3    LPP--KCNIP4    LPP--KCNMA1    LPP--KDM4C   
LPP--KLHL42    LPP--KMT2A    LPP--LEPREL1    LPP--LGR4    LPP--LIPJ    LPP--LPP    LPP--LSM1    LPP--MAP4    LPP--MDH1    LPP--MLL    LPP--MRAP2    LPP--MYH11    LPP--NDUFA10    LPP--PDE1A    LPP--PLEKHA2   
LPP--PPP2R2A    LPP--PRKCZ    LPP--PTRF    LPP--PTTG1IP    LPP--RAB7A    LPP--RABL2A    LPP--RB1    LPP--RBM6    LPP--RHOA    LPP--RNF128    LPP--RNF13    LPP--RPL39L    LPP--SH3RF1    LPP--SHFM1    LPP--SIAH1   
LPP--SKI    LPP--SLC22A3    LPP--SORBS1    LPP--SPATA16    LPP--SSU72    LPP--ST6GAL1    LPP--STAG1    LPP--STXBP4    LPP--SUGCT    LPP--TBL1XR1    LPP--TFG    LPP--TMEM135    LPP--TNFRSF10D    LPP--TP63    LPP--TPM1   
LPP--UBE2R2    LPP--XRCC6    LPP--YBX3    LPP--YLPM1    LPP--ZNF644    LPP--ZNRF1    LPP-AS2--LPP    LYPLAL1--LPP    MAP3K13--LPP    MDH1--LPP    MLL--LPP    MYO9A--LPP    NCKIPSD--LPP    NUSAP1--LPP    PPM1L--LPP   
PRKAB2--LPP    RBMS3--LPP    SEC61A1--LPP    SEMA3C--LPP    SEPT9--LPP    SFTPB--LPP    ST6GAL1--LPP    SUCLG2--LPP    TAGLN2--LPP    TC2N--LPP    TPRA1--LPP    TPRG1--LPP    XRN1--LPP    ZEB1--LPP    ZNF620--LPP   
Fusion : QuiverLPP
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLPP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LPP
dbVarLPP
ClinVarLPP
1000_GenomesLPP 
Exome Variant ServerLPP
ExAC (Exome Aggregation Consortium)ENSG00000145012
GNOMAD BrowserENSG00000145012
Varsome BrowserLPP
Genetic variants : HAPMAP4026
Genomic Variants (DGV)LPP [DGVbeta]
DECIPHERLPP [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLPP 
Mutations
ICGC Data PortalLPP 
TCGA Data PortalLPP 
Broad Tumor PortalLPP
OASIS PortalLPP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLPP  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DLPP
Mutations and Diseases : HGMDLPP
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LPP
DgiDB (Drug Gene Interaction Database)LPP
DoCM (Curated mutations)LPP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LPP (select a term)
intoGenLPP
NCG5 (London)LPP
Cancer3DLPP(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600700    601626   
Orphanet
DisGeNETLPP
MedgenLPP
Genetic Testing Registry LPP
NextProtQ93052 [Medical]
TSGene4026
GENETestsLPP
Target ValidationLPP
Huge Navigator LPP [HugePedia]
snp3D : Map Gene to Disease4026
BioCentury BCIQLPP
ClinGenLPP
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4026
Chemical/Pharm GKB GenePA30440
Clinical trialLPP
Miscellaneous
canSAR (ICR)LPP (select the gene name)
DataMed IndexLPP
Probes
Litterature
PubMed95 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLPP
EVEXLPP
GoPubMedLPP
iHOPLPP
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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