LTA (Lymphotoxin-A)
2005-02-01 Fei Chen AffiliationHealth Effects Laboratory Division, NIOSH, 1095 Willowdale Rd, Morgantown, WV 26505, USA
DNA/RNA
Description
The human TNFb gene is located next to HLA-C and HLA-B loci in chromosome 6 (6p21.3). The gene spans 2005bp with 4 exons, which transcribes a TNFb mRNA with size of 1386nt.
Proteins
Description
The human TNFb protein contains 205 amino acids. The soluble form of TNFb is usually a homotrimer with a relative molecular mass of 60 to 70 kDa, whereas the membrane form of TNFb is a heteromeric complex with lymphotoxin b (TNFc, LTb, TNFSF3). The human TNFb shares 35% identity and 50% homology in amino acid sequence with the human TNFa. The biological function of TNFb is mediated largely by TNFa receptor 1 and TNFa receptor 2. Recent studies suggested that TNFb can also recognize LIGHT ( TNFSF14) receptor.
Expression
The main cellular source of TNFb is the activated lymphocytes in immune response.
Localisation
Cell membrane, extracellular soluble form, blood stream, and biological fluids.
Function
The human TNFb is an important cytokine involved in the development of secondary lymphoid organs and inflammatory responses.
Implicated in
Disease
The polymorphism of TNFb gene in either the coding region or the promoter region has been associated with Crohn disease and myocardial infarction.
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 12949498 | 2003 | Signalling pathways of the TNF superfamily: a double-edged sword. | Aggarwal BB et al |
| 12974479 | 2003 | Lymphotoxin/light, lymphoid microenvironments and autoimmune disease. | Gommerman JL et al |
Other Information
Locus ID:
NCBI: 4049
MIM: 153440
HGNC: 6709
Ensembl: ENSG00000226979
Variants:
dbSNP: 4049
ClinVar: 4049
TCGA: ENSG00000226979
COSMIC: LTA
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000226979 | ENST00000418386 | P01374 |
| ENSG00000226979 | ENST00000418386 | Q5STV3 |
| ENSG00000226979 | ENST00000454783 | P01374 |
| ENSG00000226979 | ENST00000454783 | Q5STV3 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA443936 | Drug Hypersensitivity | Disease | ClinicalAnnotation | associated | PD | ||
| PA444546 | Hypersensitivity | Disease | ClinicalAnnotation | associated | PD | 11294926 | |
| PA448004 | abacavir | Chemical | ClinicalAnnotation | associated | PD | ||
| PA448785 | carbamazepine | Chemical | ClinicalAnnotation | associated | PD | 11294926 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36802017 | 2023 | Combined tumor necrosis factor-α (-308 G/A) and tumor necrosis factor-β (+ 252 A/G) nucleotide polymorphisms and chronicity in Egyptian children with immune thrombocytopenia. | 0 |
| 36929286 | 2023 | Prognostic significance of the genetic variant of lymphotoxin alpha (p.Thr60Asn) in egyptian patients with advanced hepatocellular carcinoma. | 0 |
| 36802017 | 2023 | Combined tumor necrosis factor-α (-308 G/A) and tumor necrosis factor-β (+ 252 A/G) nucleotide polymorphisms and chronicity in Egyptian children with immune thrombocytopenia. | 0 |
| 36929286 | 2023 | Prognostic significance of the genetic variant of lymphotoxin alpha (p.Thr60Asn) in egyptian patients with advanced hepatocellular carcinoma. | 0 |
| 33779868 | 2022 | Genetic polymorphism of tumor necrosis factor alpha (TNF-α) and tumor necrosis factor beta (TNF-β) genes and risk of oral pre-cancer and cancer in North Indian population. | 3 |
| 36430258 | 2022 | Association of LTA and SOD Gene Polymorphisms with Cerebral White Matter Hyperintensities in Migraine Patients. | 2 |
| 33779868 | 2022 | Genetic polymorphism of tumor necrosis factor alpha (TNF-α) and tumor necrosis factor beta (TNF-β) genes and risk of oral pre-cancer and cancer in North Indian population. | 3 |
| 36430258 | 2022 | Association of LTA and SOD Gene Polymorphisms with Cerebral White Matter Hyperintensities in Migraine Patients. | 2 |
| 31928491 | 2021 | Genetic Variation on TNF/LTA and TNFRSF1A Genes is Associated with Outcomes of Hepatitis C Virus Infection. | 5 |
| 33433759 | 2021 | Association between tumor necrosis factor alpha and lymphotoxin alpha gene polymorphisms and migraine occurrence among Jordanians. | 7 |
| 33436266 | 2021 | Genetic variants in TNFA, LTA, TLR2 and TLR4 genes and risk of sepsis in patients with severe trauma: nested case-control study in a level-1 trauma centre in SERBIA. | 2 |
| 33441130 | 2021 | Elevated lymphotoxin-α (TNFβ) is associated with intervertebral disc degeneration. | 2 |
| 34595982 | 2021 | Polymorphisms of the TNF, LTA, and TNFRSF1B genes are associated with onsets of menarche and menopause in US women of European ancestry. | 0 |
| 31928491 | 2021 | Genetic Variation on TNF/LTA and TNFRSF1A Genes is Associated with Outcomes of Hepatitis C Virus Infection. | 5 |
| 33433759 | 2021 | Association between tumor necrosis factor alpha and lymphotoxin alpha gene polymorphisms and migraine occurrence among Jordanians. | 7 |
Citation
Fei Chen
LTA (Lymphotoxin-A)
Atlas Genet Cytogenet Oncol Haematol. 2005-02-01
Online version: http://atlasgeneticsoncology.org/gene/41209/lta
