MIR429 (microRNA 429)

2015-08-01   Yaguang Xi , Hong Chang 

Mitchell Cancer Institute, University of South Alabama, USA. xi@health.southalabama.edu; hchang@health.southalabama.edu

Identity

HGNC
LOCATION
1p36.33
LOCUSID
ALIAS
MIRN429,hsa-mir-429,mir-429

Abstract

Review on MIR429, with data on RNA, and where it is implicated.

DNA/RNA

Atlas Image

Description

microRNA 429 located in chromosome 1 and microRNA 429 was transcribed with microRNA 200b and microRNA 200a as a ploycistronic transcript. The putative transcription start site locates about 6129 bp upstream of the precursor of microRNA 429.

Transcription

MiR-429 precursor: 5-CGCCGGCCGAUGGGCGUCUUACCAGACAUGGUUAGACCUGGCCCUCUGUCUAAUACUGUCUGGUAAAACCGUCCAUCCGCUGC-3
Mature miR-429: 5-UAAUACUGUCUGGUAAAACCGU-3

Pseudogene

No pseudogene was found.

Proteins

Note

microRNAs are not translated into proteins.

Implicated in

Entity name
Tumor cell proliferation
Note
Abnormal expression of miR-200a was reported in various tumors, including human breast cancer, gastric carcinoma, endometrial adenocarcinoma, gliomas, and colorectal carcinoma. MiR-429 could inhibit cell growth and induce apoptosis by directly targeting ONECUT2 in colorectal carcinoma and targeting BCL2 in esophageal carcinoma (Sun, Shen et al. 2014). Also, MiR-429 could induce apoptosis and suppress invasion by targeting BCL2 and SP1 in esophageal carcinoma (Wang, Li et al. 2013). However, miR-429 was also showed its anti-apoptosis function in colorectal cancer by targeting SOX2 (Li, Du et al. 2013).
Entity name
Tumor cells invasion and cancer metastasis
Note
Members of miR-200 family showed vital roles in tumor cells invasion and cancer metastasis. As to miR-429, studies demonstrated it could repress tumor cell invasion and cancer metastasis by targeting ONECUT2 and SP1 in different tumors (Sun, Shen et al. 2014; Wang, Li et al. 2013).
Entity name
Repression of epithelial-mesenchymal transition (EMT)
Note
EMT is an important feature of tumor cells. Tumor cells underwent EMT showed more invasion and metastatic properties. Studies demonstrated members of miR-200 family could directly target ZEB1 and ZEB2 and could be regulated as a feedback loop during EMT. Ectopic over-expression of miR-429 induces mesenchymal-to-epithelial transition (MET) in metastasizing ovarian cancer cells (Chen, Wang et al. 2011). In colorectal carcinoma cells, miR-429 could regulate EMT-related markers such as ZEB2, Vimentin, SNAI2 (SLUG) and SNAI1 (SNAIL) by targeting ONECUT2 (Sun, Shen et al. 2014).
Entity name
Chemoresistance
Note
Cancer stem cells showed highly resistance to chemotherapy which make relapse of tumor. It was found that over-expression of miR-429 could increase drug sensitivity in metastasizing ovarian (Wang, Mezencev et al. 2014). However, it was reported that miR-429 was highly expressed in hepatocellular carcinoma tissues and enrichment of miR-429 in liver tumour-initiating cells with EPCAM expression would contributed to hepatocyte self-renewal, malignant proliferation, chemoresistance and tumorigenicity (Li, Tang et al. 2014).

Bibliography

Pubmed IDLast YearTitleAuthors
212770122011Overexpression of miR-429 induces mesenchymal-to-epithelial transition (MET) in metastatic ovarian cancer cells.Chen J et al
231111032013MiR-429 is an independent prognostic factor in colorectal cancer and exerts its anti-apoptotic function by targeting SOX2.Li J et al
245721412015Epigenetic modification of MiR-429 promotes liver tumour-initiating cell properties by targeting Rb binding protein 4.Li L et al
244027832014MiR-429 inhibits cells growth and invasion and regulates EMT-related marker genes by targeting Onecut2 in colorectal carcinoma.Sun Y et al
248027242014Ectopic over-expression of miR-429 induces mesenchymal-to-epithelial transition (MET) and increased drug sensitivity in metastasizing ovarian cancer cells.Wang L et al
239998732013MiR-429 up-regulation induces apoptosis and suppresses invasion by targeting Bcl-2 and SP-1 in esophageal carcinoma.Wang Y et al

Other Information

Locus ID:

NCBI: 554210
MIM: 612094
HGNC: 13784
Ensembl: ENSG00000198976
miRBase:

Variants:

dbSNP: 554210
ClinVar: 554210
TCGA: ENSG00000198976
COSMIC: MIR429

RNA/Proteins

Expression (GTEx)

0
1
2
3
4

References

Pubmed IDYearTitleCitations
210790002010miR-200 family and targets, ZEB1 and ZEB2, modulate uterine quiescence and contractility during pregnancy and labor.95
205140232010miR-200bc/429 cluster targets PLCgamma1 and differentially regulates proliferation and EGF-driven invasion than miR-200a/141 in breast cancer.77
198016812009The miR200 family of microRNAs regulates WAVE3-dependent cancer cell invasion.56
244027832014MiR-429 inhibits cells growth and invasion and regulates EMT-related marker genes by targeting Onecut2 in colorectal carcinoma.49
231111032013MiR-429 is an independent prognostic factor in colorectal cancer and exerts its anti-apoptotic function by targeting SOX2.44
255504632015The hypoxia-inducible miR-429 regulates hypoxia-inducible factor-1α expression in human endothelial cells through a negative feedback loop.38
254053872015miR-429 inhibits migration and invasion of breast cancer cells in vitro.29
273804942016Long noncoding RNA GIHCG promotes hepatocellular carcinoma progression through epigenetically regulating miR-200b/a/429.28
259092232015MiR-200b/200c/429 subfamily negatively regulates Rho/ROCK signaling pathway to suppress hepatocellular carcinoma metastasis.24
269545872016miR-429 regulates the transition between Hypoxia-Inducible Factor (HIF)1A and HIF3A expression in human endothelial cells.21

Citation

Yaguang Xi ; Hong Chang

MIR429 (microRNA 429)

Atlas Genet Cytogenet Oncol Haematol. 2015-08-01

Online version: http://atlasgeneticsoncology.org/gene/51154/mir429